CO₂combining power and outcomes in patients with acute ischaemic stroke or transient ischaemic attack

Abstract

Background and purposeThe clinical significance of carbon dioxide combining power (CO2CP) in ischaemic cerebrovascular disease is not well established, and the role of CO2CP in the prognosis of acute ischaemic stroke (AIS) or transient ischaemic attack (TIA) has not been reported. The objective of the study was to investigate the associations between CO2CP and clinical outcomes in patients with AIS or TIA.MethodsData were derived from the China National Stroke Registry III. Patients were classified into five groups by quintiles of CO2CP levels and three groups according to the normal range of CO2CP (23–29 mmol/L). Multivariable Cox and logistic regressions were adopted to explore the associations of CO2CP levels with all-cause death and poor functional outcomes (modified Rankin Scale (mRS) 3–6/2–6) at 3 months and 1 year.ResultsAmong 9531 patients included in the study, the median (IQR) CO2CP was 24.9 (23.0–27.0) mmol/L. After adjustment for potential confounders, patients in the first CO2CP quintile (21.1–23.3 mmol/L) had higher risk of all-cause death and poor functional outcomes (mRS score of 3–6/2–6) (HR or OR with 95% CI 2.37 (1.32 to 4.25), 1.49 (1.20 to 1.83) and 1.21 (1.03 to 1.42), respectively) compared with those in the fourth quintile. Similar results were found for outcomes at 1 year. Furthermore, all associations were also significant when CO2CP was <23 mmol/L compared with CO2CP of 23–29 mmol/L.ConclusionsDecreased CO2CP was associated with high risk of all-cause death and poor functional outcomes in patients with AIS or TIA.

Predictors and Prognosis of Symptomatic Intracranial Hemorrhage in Acute Ischemic Stroke Patients Without Thrombolysis: Analysis of Data From the Chinese Acute Ischemic Stroke Treatment Outcome Registry

“…There was a relatively lower mortality (1.1% at 3 months and 2.0% at 12 months) in our study, which was similar to the results based on the Third China National Stroke Registry (1.3% at 3 months and 2.9% at 12 months) ( 39 ). Andrade et al ( 40 ) reported a mortality of 6.9% at discharge and Paciaroni et al ( 2 ) reported a mortality of 11.5% at 3 months in stroke patients.…”

Miniaturized nonresonant photoacoustic gas analyzer for CO2 detection

“…Detection of trace carbon dioxide (CO 2 ) is important and can be applied to many places such as combustion products, greenhouse gas monitoring, and medical diagnosis. [1][2][3][4][5] Different concentrations of CO 2 can reflect the risk of exposing COVID-19. 6,7 Besides, a fire will cause soaring CO 2 (increasing about 25%) within four minutes.…”

Predictive value of admission CO2 combining power combined with serum sodium for the prognosis in acute Stanford type A aortic dissection patients

“…In clinic, CO 2 combing power (CO 2 CP) as a low cost and time-saving auxiliary diagnosis usually reflects the homeostasis of acidosis and alkalosis. Accumulating evidence shows the low CO 2 CP level linking with the worse prognosis of patients with olorectal cancer, acute kidney injury, acute ischaemic stroke [17][18][19] . Similarly, the latest reports also indicates the increased lactic acid as an independent risk factor for ATAAD complications, including postoperative acute kidney and lung injury 20,21 , thereby driving the application of acid-base balance index on prognosis.…”