CO₂‐Assisted Stereocontrolled Multi‐Component Coupling Reactions Promoted by Ni‐Catalytic System

Abstract

A combination of Ni-catalyst and PPh 3 promotes the three-component coupling reaction of vinyl epoxide, alkyne, and dimethylzinc under a carbon dioxide atmosphere to provide 2,5-heptadienyl alcohols with excellent E-stereo-selectivity. The stereochemistry of the products from the multi-component coupling reaction is controlled via an oxanickelacycle intermediate, which is formed by the insertion of carbon dioxide.