CO₂-Assisted asymmetric hydrogenation of prochiral allylamines

Abstract

CO2 can act as an in situ protecting group for the asymmetric hydrogenation of allylamines.

Stereocomplementary Synthesis of β‐Aryl Propanamines by Enzymatic Dynamic Kinetic Resolution‐Reductive Amination

“…The most extensively explored strategy is metal‐catalyzed asymmetric hydrogenation of unsaturated nitrogen‐containing substrates. For example, Rh [7] ‐, Ru [8] ‐ and Ir [9] ‐catalyzed asymmetric hydrogenation of 2‐aryl allylic amines with or without a N ‐protected group have been applied to synthesize β‐aryl propanamines with moderate to high ee values and yield (Scheme 1 (a)). N ‐(2‐arylprop‐1‐en‐1‐yl)acetamides were also hydrogenated to β‐aryl propanamines in 95–96 % yields and 88–96 % ee catalyzed by Rh complex [10] .…”