Co Single‐Atom Catalysts Boost Chemiluminescence

Ouyang, Hui; Zhang, Lvxia; Jiang, Shan; Wang, Wenwen; Zhu, Chengzhou; Fu, Zhifeng

doi:10.1002/chem.202002330

Cited by 43 publications

(41 citation statements)

References 48 publications

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“…Lately, the increasing interest of the scientific community in novel therapies has led to further exploration of 1 O 2 against persisting diseases (i.e., cancer). Thus, a significant amount of the new studies are now focused on the generation modes and the photophysical properties [141], dictating its interaction with other biomolecules in live cells. On the other hand, 1 O 2 is a very important oxidizing agent in organic chemistry transformations.…”

Section: The Dual Role Of Singlet Oxygen In Chemiluminescencementioning

confidence: 99%

Direct and Indirect Chemiluminescence: Reactions, Mechanisms and Challenges

et al. 2021

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Emission of light by matter can occur through a variety of mechanisms. When it results from an electronically excited state of a species produced by a chemical reaction, it is called chemiluminescence (CL). The phenomenon can take place both in natural and artificial chemical systems and it has been utilized in a variety of applications. In this review, we aim to revisit some of the latest CL applications based on direct and indirect production modes. The characteristics of the chemical reactions and the underpinning CL mechanisms are thoroughly discussed in view of studies from the very recent bibliography. Different methodologies aiming at higher CL efficiencies are summarized and presented in detail, including CL type and scaffolds used in each study. The CL role in the development of efficient therapeutic platforms is also discussed in relation to the Reactive Oxygen Species (ROS) and singlet oxygen (1O2) produced, as final products. Moreover, recent research results from our team are included regarding the behavior of commonly used photosensitizers upon chemical activation under CL conditions. The CL prospects in imaging, biomimetic organic and radical chemistry, and therapeutics are critically presented in respect to the persisting challenges and limitations of the existing strategies to date.

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Section: The Dual Role Of Singlet Oxygen In Chemiluminescencementioning

confidence: 99%

Direct and Indirect Chemiluminescence: Reactions, Mechanisms and Challenges

et al. 2021

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“…In the presence of H 2 O 2 , this SAN inhibited the growth of P. aeruginosa by up to 99.87% and also promoted in vivo bacteria-infected wound disinfection and healing [ 65 ]. Recently, SANs with carbon nanoframe-confined FeN 5 active centers, which catalytically behaved like the axial ligand-coordinated scheme of cytochrome P450, were reported by Huang et al Synergistic effects furnish FeN 5 SANs with a clear electron push-effect mechanism and also the highest OXD-like activity among other nanozymes (the rate constant 70 times higher than commercial Pt/C) and versatile antibacterial applications [ 66 ].…”

Section: Nanozyme Platforms For Antibacterial Applicationsmentioning

confidence: 99%

Emerging Prospects of Nanozymes for Antibacterial and Anticancer Applications

et al. 2022

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The ability of some nanoparticles to mimic the activity of certain enzymes paves the way for several attractive biomedical applications which bolster the already impressive arsenal of nanomaterials to combat deadly diseases. A key feature of such ‘nanozymes’ is the duplication of activities of enzymes or classes of enzymes, such as catalase, superoxide dismutase, oxidase, and peroxidase which are known to modulate the oxidative balance of treated cells for facilitating a particular biological process such as cellular apoptosis. Several nanoparticles that include those of metals, metal oxides/sulfides, metal–organic frameworks, carbon-based materials, etc., have shown the ability to behave as one or more of such enzymes. As compared to natural enzymes, these artificial nanozymes are safer, less expensive, and more stable. Moreover, their catalytic activity can be tuned by changing their size, shape, surface properties, etc. In addition, they can also be engineered to demonstrate additional features, such as photoactivated hyperthermia, or be loaded with active agents for multimodal action. Several researchers have explored the nanozyme-mediated oxidative modulation for therapeutic purposes, often in combination with other diagnostic and/or therapeutic modalities, using a single probe. It has been observed that such synergistic action can effectively by-pass the various defense mechanisms adapted by rogue cells such as hypoxia, evasion of immuno-recognition, drug-rejection, etc. The emerging prospects of using several such nanoparticle platforms for the treatment of bacterial infections/diseases and cancer, along with various related challenges and opportunities, are discussed in this review.

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“…Recently, several enzymes are used as catalysts for enhancing CL intensity, such as horseradish peroxidase, alkaline phosphatase and laccase. [40][41][42][43] Besides, metal complexes, [44] porphyrins, [45] and Co single-atom catalysts (SACs) [46] also display catalytic activity for some CL reactions.…”

Section: Other Factorsmentioning

confidence: 99%

“…Currently, the chemiluminescence acceptors are mainly fluorescent dyes (13-41, Figure 4B) and semiconducting poly- mers (42)(43)(44)(45)(46)Figure 4C). [14,22,30,38,39,67,[71][72][73][74][75][76][77][78][79] We summarize the chemiluminescence emission of these acceptors and the limitation of detection (LOD) of H 2 O 2 and calculated their HOMO energy by performing density functional theory (DFT) (Table 1).…”

Section: Peroxyoxalate-based Chemiluminescent Probesmentioning

confidence: 99%

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Activatable Chemiluminescent Molecular Probes for Bioimaging and Biosensing

Yang

Zhang

2021

Analysis & Sensing

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Chemiluminescence (CL) is a very promising method for applications in analytic chemistry and biological systems due to the elimination of the external light source, which could reduce autofluorescence interference and improve the signal‐to‐noise ratio (SNR) and tissue penetration depth. The fluorescent dyes, chemiluminescent initiator, and reaction temperature are three crucial factors that determine the chemiluminescence efficiency. Up to now, significant development of chemiluminescence probes has been reported for high‐performance imaging and sensing, including the systems based on luminol, imidazopyrazinone, peroxyoxalate, and Schaap's dioxetane. In this review, we give an overview of the current chemiluminescence probes and their bioimaging and biosensing applications. We also provide perspectives on designing chemiluminescent probes with good efficiency and longer emission wavelengths.

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Co Single‐Atom Catalysts Boost Chemiluminescence

Cited by 43 publications

References 48 publications

Direct and Indirect Chemiluminescence: Reactions, Mechanisms and Challenges

Direct and Indirect Chemiluminescence: Reactions, Mechanisms and Challenges

Emerging Prospects of Nanozymes for Antibacterial and Anticancer Applications

Activatable Chemiluminescent Molecular Probes for Bioimaging and Biosensing

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