Co-responsive smart cyclodextrin-gated mesoporous silica nanoparticles with ligand-receptor engagement for anti-cancer treatment

Wu, Yaling; Xu, Zheng; Sun, Wenjing; Yang, Yingyue; Jin, Hui; Qiu, Lipeng; Chen, Jinghua; Chen, Jingxiao

doi:10.1016/j.msec.2019.109831

Cited by 47 publications

(33 citation statements)

References 60 publications

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“…The obtained formulation demonstrated improved internalization ability and increased accumulation capacity in these cancer cells both in vitro and in vivo. The authors of [225] immobilized β-CD in combination with azobenzene/galactose-grafted polymer (GAP) on the surface of mesoporous silica nanoparticles. The latter is a well-known ligand for targeting asialoglycoprotein receptors of HepG2 cells and controllable release of encapsulated cargo.…”

Section: Mesoporous Silica Nanoparticles Modified By Synthetic Polymersmentioning

confidence: 99%

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Kashapov

Ibragimova

Pavlov

et al. 2021

IJMS

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Encapsulation of cargoes in nanocontainers is widely used in different fields to solve the problems of their solubility, homogeneity, stability, protection from unwanted chemical and biological destructive effects, and functional activity improvement. This approach is of special importance in biomedicine, since this makes it possible to reduce the limitations of drug delivery related to the toxicity and side effects of therapeutics, their low bioavailability and biocompatibility. This review highlights current progress in the use of lipid systems to deliver active substances to the human body. Various lipid compositions modified with amphiphilic open-chain and macrocyclic compounds, peptide molecules and alternative target ligands are discussed. Liposome modification also evolves by creating new hybrid structures consisting of organic and inorganic parts. Such nanohybrid platforms include cerasomes, which are considered as alternative nanocarriers allowing to reduce inherent limitations of lipid nanoparticles. Compositions based on mesoporous silica are beginning to acquire no less relevance due to their unique features, such as advanced porous properties, well-proven drug delivery efficiency and their versatility for creating highly efficient nanomaterials. The types of silica nanoparticles, their efficacy in biomedical applications and hybrid inorganic-polymer platforms are the subject of discussion in this review, with current challenges emphasized.

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Section: Mesoporous Silica Nanoparticles Modified By Synthetic Polymersmentioning

confidence: 99%

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Kashapov

Ibragimova

Pavlov

et al. 2021

IJMS

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“…As a main contributor of redox status in cells, GSH plays a critical role in cellular activities. Disulfide bonds [54][55][56], ferrocene [57], boronic ester [58], and tetrathiafulvalene [50] are considered as promising tools for designing redox-responsive nanocarriers. These structures are highly stable in the extracellular environment with a low level of GSH, while they tend to breakdown in reductive environments.…”

Section: Redox Potentialmentioning

confidence: 99%

“…To improve the efficiency and precision of drug delivery, dual responsive nanoplatforms have been built [58,121,122]. For instance, β-cyclodextrin and azobenzene/galactosegrafted polymer were introduced for the fabrication and functionalization of mesoporous silica nanoparticles to impart both light and redox sensitivity for preventing leakage of the payload and for increasing the chemotherapeutic performance of DOX [54]. Upon UV radiation, azobenzene moieties were dissociated from the surface, which caused the release of DOX.…”

Section: Multi-responsive Systemmentioning

confidence: 99%

Smart Nanoparticles for Chemo-Based Combinational Therapy

et al. 2021

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Cancer is a heterogeneous and complex disease. Traditional cancer therapy is associated with low therapeutic index, acquired resistance, and various adverse effects. With the increasing understanding of cancer biology and technology advancements, more strategies have been exploited to optimize the therapeutic outcomes. The rapid development and application of nanomedicine have motivated this progress. Combinational regimen, for instance, has become an indispensable approach for effective cancer treatment, including the combination of chemotherapeutic agents, chemo-energy, chemo-gene, chemo-small molecules, and chemo-immunology. Additionally, smart nanoplatforms that respond to external stimuli (such as light, temperature, ultrasound, and magnetic field), and/or to internal stimuli (such as changes in pH, enzymes, hypoxia, and redox) have been extensively investigated to improve precision therapy. Smart nanoplatforms for combinational therapy have demonstrated the potential to be the next generation cancer treatment regimen. This review aims to highlight the recent advances in smart combinational therapy.

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“…These biomolecules have also been explored as targeting agents owing to their ability to interact in a very specific manner with overexpressed lectin proteins present on the cell membrane. For instance, the asialoglycoprotein receptor can be targeted using MSNs functionalized with galactose [149] or lactobionic acid [150][151][152][153]. In addition, the conjugation of glucose derivatives with MSNs are useful for targeting overexpressed GLUT receptors [154,155].…”

Section: Carbohydratesmentioning

confidence: 99%

“…In this manner, enhanced drug release can be observed when MSNs reach the cytoplasm and GSH completely removes the β-CD caps [325,326]. A nice feature of β-CDs is that not only they serve as gatekeeper, but also provide possibilities for further functionalization, including PEGylation [327] and grafting of targeting agents [149,201,328,329].…”

Section: Small Nanoparticles and Nanovalvesmentioning

confidence: 99%

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

Gisbert-Garzarán

Vallet‐Regí

2020

Nanomaterials

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Mesoporous silica nanoparticles have been broadly applied as drug delivery systems owing to their exquisite features, such as excellent textural properties or biocompatibility. However, there are various biological barriers that prevent their proper translation into the clinic, including: (1) lack of selectivity toward tumor tissues, (2) lack of selectivity for tumoral cells and (3) endosomal sequestration of the particles upon internalization. In addition, their open porous structure may lead to premature drug release, consequently affecting healthy tissues and decreasing the efficacy of the treatment. First, this review will provide a comprehensive and systematic overview of the different approximations that have been implemented into mesoporous silica nanoparticles to overcome each of such biological barriers. Afterward, the potential premature and non-specific drug release from these mesoporous nanocarriers will be addressed by introducing the concept of stimuli-responsive gatekeepers, which endow the particles with on-demand and localized drug delivery.

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Co-responsive smart cyclodextrin-gated mesoporous silica nanoparticles with ligand-receptor engagement for anti-cancer treatment

Cited by 47 publications

References 60 publications

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Smart Nanoparticles for Chemo-Based Combinational Therapy

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

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