CO-releasing properties and anticancer activities of manganese complexes with imidazole/benzimidazole ligands

Üstün, Elvan; Özgür, Aykut; Coşkun, Kübra Açıkalın; Demır, Serpıl; Özdemır, İsmaıl; Tutar, Yusuf

doi:10.1080/00958972.2016.1231921

Cited by 39 publications

(11 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In line with in vitro experiments, different tumor-bearing rodent models have also indicated the inhibitory effects on tumor growth of this CO donor [ 63 , 65 , [68] , [69] , [70] , [71] ]. Besides, a variety of novel CO-RMs have been designed and synthesized successfully, which have showed similar anticancer actions in both in vitro studies [ [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] ] and in vivo experiments [ 65 , 69 , 79 ]. In contrast, an in vitro study using human hepatocellular carcinoma cell lines showed that cell cycle arrest was attenuated by the pretreatment with CORM-2, interrupting the inhibition of cancer cell growth [ 81 ].…”

Section: Anticancer Activities Of Co-rms By Targeting Cancer Hallmarksmentioning

confidence: 99%

The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine

Tuan

et al. 2021

Redox Biology

View full text Add to dashboard Cite

Carbon monoxide (CO) is now well recognized a pivotal endogenous signaling molecule in mammalian lives. The proof-of-concept employing chemical carriers of exogenous CO as prodrugs for CO release, also known as CO-releasing molecules (CO-RMs), has been appreciated. The major advantage of CO-RMs is that they are able to deliver CO to the target sites in a controlled manner. There is an increasing body of experimental studies suggesting the therapeutic potentials of CO and CO-RMs in different cancer models. This review firstly presents a short but crucial view concerning the characteristics of CO and CO-RMs. Then, the anticancer activities of CO-RMs that target many cancer hallmarks, mainly proliferation, apoptosis, angiogenesis, and invasion and metastasis, are discussed. However, their anticancer activities are varying and cell-type specific. The aerobic metabolism of molecular oxygen inevitably generates various oxygen-containing reactive metabolites termed reactive oxygen species (ROS) which play important roles in both physiology and pathophysiology. Although ROS act as a double-edged sword in cancer, both sides of which may potentially have been exploited for therapeutic benefits. The main focus of the present review is thus to identify the possible signaling network by which CO-RMs can exert their anticancer actions, where ROS play the central role. Another important issue concerning the potential effect of CO-RMs on the aerobic glycolysis (the Warburg effect) which is a feature of cancer metabolic reprogramming is given before the conclusion with future prospects on the challenges of developing CO-RMs into clinically pharmaceutical candidates in cancer therapy.

show abstract

Section: Anticancer Activities Of Co-rms By Targeting Cancer Hallmarksmentioning

confidence: 99%

The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine

Tuan

et al. 2021

Redox Biology

View full text Add to dashboard Cite

show abstract

“…[ 32,33 ] The complexes a and b show antiproliferative activity against breast cancer cell lines under UV irradiation whereas c , d , and e show a dose‐dependent toxicity towards breast and colon cancer cells when exposed to low power visible light (Figure 1). [ 34–40 ]…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic, CO‐releasing ability, and anticancer activity studies of [Mn(CO)₃(L–L)Br] complexes: Experimental and density functional theory studies

Thomas

Vidhyapriya²,

Sivan

et al. 2022

Applied Organom Chemis

View full text Add to dashboard Cite

Two different series of manganese(I) tricarbonyl complexes containing phosphine‐based (1–5) and 4′‐substituted 2,2′:6′,2″‐terpyridine‐based ligands (6–10) have been synthesized in order to study their CO‐releasing ability and to investigate their anticancer activity. All the synthesized complexes (1–10) have been fully characterized using standard spectroscopic and analytical techniques. Further 5, 7, and 9 have also been characterized by single‐crystal X‐ray diffraction studies. Although both the sets of ligands are π‐acceptors, they tend to change the Mn—CO bond strength upon complexation, thus affecting the CO release. Photoactivation of 1–5 and 6–10 has been achieved using 365 nm UV irradiation and low intensity visible light, respectively. The MnCO bond strength has been examined using the density functional theory (DFT) and time‐dependent DFT (TD‐DFT) calculations. In order to find the therapeutic viability of the visible light activated complexes, their cytotoxicity has been investigated both in the dark and under irradiation. The MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide) assay reveals the potential application of some of the synthesized complexes especially towards the lung cancer cells in the dark condition.

show abstract

“…Moreover, this complex had better CO release capabilities than the tris-pyrazolyl CORM of Schatzschneider. Recently, the group of Kelebekli reported novel tricarbonyl Mn complexes bearing bipyridiyl and imidazole derivatives (7 and 8, Figure 2) [54,55]. This set of complexes showed effective cancer treatment and cytotoxic activity against breast cancer cells and the MCF-7 human cell line.…”

Section: Uv Light Photoactivated Cormsmentioning

confidence: 99%

Visible Light-Activated PhotoCORMs

Kottelat

Zobi

2017

Inorganics

View full text Add to dashboard Cite

Despite its well-known toxicity, carbon monoxide (CO) is now recognized as a potential therapeutic agent. Its inherent toxicity, however, has limited clinical applications because uncontrolled inhalation of the gas leads to severe systemic derangements in higher organisms. In order to obviate life-threatening effects and administer the gas by bypassing the respiratory system, CO releasing molecules (CORMs) have emerged in the last decades as a plausible alternative to deliver controlled quantities of CO in cellular systems and tissues. As stable, solid-storage forms of CO, CORMs can be used to deliver the gas following activation by a stimulus. Light-activated CORMs, known as photoCORMs, are one such example. This class of molecules is particularly attractive because, for possible applications of CORMs, temporal and spatial control of CO delivery is highly desirable. However, systems triggered by visible light are rare. Most currently known photoCORMs are activated with UV light, but red light or even infrared photo-activation is required to ensure that structures deeper inside the body can be reached while minimizing photo-damage to healthy tissue. Thus, one of the most challenging chemical goals in the preparation of new photoCORMs is the reduction of radiation energy required for their activation, together with strategies to modulate the solubility, stability and nontoxicity of the organic or organometallic scaffolds. In this contribution, we review the latest advances in visible light-activated photoCORMs, and the first promising studies on near-infrared light activation of the same.

show abstract

CO-releasing properties and anticancer activities of manganese complexes with imidazole/benzimidazole ligands

Cited by 39 publications

References 50 publications

The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine

The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine

Synthesis, spectroscopic, CO‐releasing ability, and anticancer activity studies of [Mn(CO)₃(L–L)Br] complexes: Experimental and density functional theory studies

Visible Light-Activated PhotoCORMs

Contact Info

Product

Resources

About

CO-releasing properties and anticancer activities of manganese complexes with imidazole/benzimidazole ligands

Cited by 39 publications

References 50 publications

The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine

The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine

Synthesis, spectroscopic, CO‐releasing ability, and anticancer activity studies of [Mn(CO)3(L–L)Br] complexes: Experimental and density functional theory studies

Visible Light-Activated PhotoCORMs

Contact Info

Product

Resources

About

Synthesis, spectroscopic, CO‐releasing ability, and anticancer activity studies of [Mn(CO)₃(L–L)Br] complexes: Experimental and density functional theory studies