Co‐registration of acquired MR ventilation and perfusion images—Validation in a porcine model

Rizi, Rahim R.; Saha, Punam K.; Wang, Binquan; Ferrante, Michael F.; Lipson, David A.; Baumgardner, James E.; Roberts, David A.

doi:10.1002/mrm.10359

Cited by 21 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10 In an animal model, promising results concerning quantification of pulmonary perfusion using a time-resolved inversion recovery technique with ultra-short echo-times have been published. 20 Initial studies have presented data on absolute quantification of pulmonary perfusion in human subjects, including a limited number of patients and reporting a broad interindividual variation of results. 9,21 Quantitative assessment of lung perfusion is desirable for several reasons: It would enable interindividual comparison of patients with various pathologies, and an intraindividual assessment after surgical or other medical treatment, eg, longitudinal assessment of drug treatment of pulmonary hypertension using prostaglandin-derivates.…”

Section: Discussionmentioning

confidence: 99%

Quantification of Pulmonary Blood Flow and Volume in Healthy Volunteers by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using a Parallel Imaging Technique

Nikolaou¹,

Schoenberg²,

Brix³

et al. 2004

Investigative Radiology

100

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Quantification of Pulmonary Blood Flow and Volume in Healthy Volunteers by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using a Parallel Imaging Technique

Nikolaou¹,

Schoenberg²,

Brix³

et al. 2004

Investigative Radiology

100

View full text Add to dashboard Cite

show abstract

“…Image registration of hyperpolarized gas MRI has previously been published in the context of perfusion MRI using controlled gas administration in pigs (Rizi et al, 2003;Hong et al, 2005) while human in vivo 3 He MRI to CT image registration has been reported as part of a study on the feasibility of lung cancer treatment planning with 3 He MRI (Ireland et al, 2007a). Furthermore, the importance of the image acquisition procedures on the resultant image registration of 3 He MRI to CT has been demonstrated (Ireland et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

A method for quantitative analysis of regional lung ventilation using deformable image registration of CT and hybrid hyperpolarized gas/¹H MRI

et al. 2014

View full text Add to dashboard Cite

This is a repository copy of ReuseUnless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request.A method for quantitative analysis of regional lung ventilation using deformable image registration of CT and hybrid Short Title Hyperpolarised gas MRI and CT image registration AbstractHyperpolarized gas MRI generates highly detailed maps of lung ventilation and physiological function while CT provides corresponding anatomical and structural information. Fusion of such complementary images enables quantitative analysis of pulmonary structure-function. However, direct image registration of hyperpolarized gas MRI to CT is problematic, particularly in lungs whose boundaries are difficult to delineate due to ventilation heterogeneity. This study presents a novel indirect method of registering hyperpolarized gas MRI to CT utilizing 1 H-structural MR images that are acquired in the same breath-hold as the gas MRI. The feasibility of using this technique for regional quantification of ventilation of specific pulmonary structures is demonstrated for the lobes.The direct and indirect methods of hyperpolarized gas MRI to CT image registration were compared using lung images from 15 asthma patients. Both affine and diffeomorphic image transformations were implemented. Registration accuracy was evaluated using the target registration error (TRE) of anatomical landmarks identified on 1 H MRI and CT. Wilcoxon signed-rank test was used to test statistical significance.For the affine transformation, the indirect method of image registration was significantly more accurate than the direct method (TRE=14.7±3.2 vs. 19.6±12.7mm, p=0.036). Using a deformable transformation, the indirect method was also more accurate than the direct method (TRE=13.5±3.3 vs. 20.4±12.8mm, p=0.006).Accurate image registration is critical for quantification of regional lung ventilation with hyperpolarized gas MRI within the anatomy delineated by CT. Automatic deformable image registration of hyperpolarized gas MRI to CT via same breath-hold 1 H MRI is more accurate than direct registration. Potential applications include improved multi-modality image fusion, functionally-weighted radiotherapy planning, and quantification of lobar ventilation in obstructive airways disease.

show abstract

“…Recently, there have been publications on pulmonary ventilation and perfusion imaging using 3 He-MRI with intravenous application of paramagnetic gadolinium contrast medium or by combination of 3 He-MRI and proton MRI [25,26]. Since the PO 2 in the lung is a result of the balance between ventilation and perfusion, determination of the V/Q ratio is feasible with knowledge of the oxygen-hemoglobin binding curve.…”

Section: Discussionmentioning

confidence: 99%

Two-dimensional and three-dimensional oxygen mapping by 3He-MRI validation in a lung phantom

Gast¹,

Schreiber²,

Herweling³

et al. 2005

Eur Radiol

View full text Add to dashboard Cite

The aim of this study was to validate oxygen-sensitive 3He-MRI in noninvasive determination of the regional, two- and three-dimensional distribution of oxygen partial pressure. In a gas-filled elastic silicon ventilation bag used as a lung phantom, oxygen sensitive two- and three-dimensional 3He-MRI measurements were performed at different oxygen concentrations which had been equilibrated in a range of normal and pathologic values. The oxygen partial pressure distribution was determined from 3He-MRI using newly developed software allowing for mapping of oxygen partial pressure. The reference bulk oxygen partial pressure inside the phantom was measured by conventional respiratory gas analysis. In two-dimensional measurements, image-based and gas-analysis results correlated with r=0.98; in three-dimensional measurements the between-methods correlation coefficient was r=0.89. The signal-to-noise ratio of three-dimensional measurements was about half of that of two-dimensional measurements and became critical (below 3) in some data sets. Oxygen-sensitive 3He-MRI allows for noninvasive determination of the two- and three-dimensional distribution of oxygen partial pressure in gas-filled airspaces.

show abstract

Co‐registration of acquired MR ventilation and perfusion images—Validation in a porcine model

Cited by 21 publications

References 21 publications

Quantification of Pulmonary Blood Flow and Volume in Healthy Volunteers by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using a Parallel Imaging Technique

Quantification of Pulmonary Blood Flow and Volume in Healthy Volunteers by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using a Parallel Imaging Technique

A method for quantitative analysis of regional lung ventilation using deformable image registration of CT and hybrid hyperpolarized gas/¹H MRI

Two-dimensional and three-dimensional oxygen mapping by 3He-MRI validation in a lung phantom

Contact Info

Product

Resources

About

Co‐registration of acquired MR ventilation and perfusion images—Validation in a porcine model

Cited by 21 publications

References 21 publications

Quantification of Pulmonary Blood Flow and Volume in Healthy Volunteers by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using a Parallel Imaging Technique

Quantification of Pulmonary Blood Flow and Volume in Healthy Volunteers by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using a Parallel Imaging Technique

A method for quantitative analysis of regional lung ventilation using deformable image registration of CT and hybrid hyperpolarized gas/1H MRI

Two-dimensional and three-dimensional oxygen mapping by 3He-MRI validation in a lung phantom

Contact Info

Product

Resources

About

A method for quantitative analysis of regional lung ventilation using deformable image registration of CT and hybrid hyperpolarized gas/¹H MRI