Co-receptor regulation of insulin signaling

Cholecystokinin‐mediated effect of insulin pathway on the steroidogenic activity of follicular granulosa cells in Camelus bactrianus: In vitro study

“…Studies have revealed that insulin exerts direct and indirect effects on the production of ovarian steroids, as well as on the growth of granulosa cells and follicular membrane cells in cattle, both in vitro and in vivo (Loverro et al., 2001). INS and INSR binding can jointly regulate blood glucose and metabolism, and play a role in regulating follicular development, oestrogen synthesis and ovarian function (Prisca & Heiko, 2022). The secretion of insulin can promote the release of IGFs, and its receptor IGF‐1R is a transmembrane receptor tyrosine kinase distributed in various tissues throughout the body (Belardi et al., 2013).…”

“…Similarly, in this experiment, significant changes were found in the mRNA expression levels of INSR , IGF and IGFR in follicular granulosa cells by regulating the level of CCK. Research has found that INS and its receptors can interact with oestrogen, regulate sexual maturity in the body (Prisca & Heiko, 2022), and IGF can promote the biosynthesis of oestrogen and progesterone (Todd et al., 2007), IGF‐1R plays an important role in normal ovarian function and is influenced and regulated by oestrogen (Shapiro et al., 2023). Oestrogen mainly acts through two receptor subtypes, including ERα and ERβ.…”