Co‐production of microbial lipids with valuable chemicals

Abstract

Microbial lipids are promising substitutes for petroleum and plant oil. However, the industrialization of microbial lipids is still limited and cannot compete with petrochemical petroleum due to its high production cost. Microorganisms capable of accumulating lipids and additional valuable chemicals are attractive for improving the economics of the microbial lipid production process. Compared with the increase in production of complex metabolic engineering to improve the overall economy, the multi‐chemical co‐production system is more advantageous in balancing the metabolic flux and optimal cell physiological recovery. In this review, various chemicals co‐produced with microbial lipids are classified according to their cell location. Efficient strategies, including the fermentation process and genetic engineering for regulating and enhancing such co‐production systems, are comprehensively discussed. The prospective and challenges during the scale‐up of lipids and valuable chemicals co‐production process are also highlighted. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd

Co‐production of lipids and carotenoids by Rhodosporidium toruloides from cane molasses using temperature and pH shifting strategies

“…27 Rhodosporidium toruloides, as a potential industrial lipidproducing yeast, has excellent lipid synthesis ability (70% of dry cell weight). 16,28 For example, when glucose was used as the carbon source for batch fed fermentations, R. toruloides produced 67.5% of lipids after 134 h. 4 In this research, the final lipid production using the Z11 strain reached 78.6% after 120 h of batch-fed fermentation with glucose as carbon source, which was much higher than the reported levels (Fig. 5).…”

“…Rhodosporidium toruloides , as a potential industrial lipid‐producing yeast, has excellent lipid synthesis ability (70% of dry cell weight) 16,28 . For example, when glucose was used as the carbon source for batch fed fermentations, R. toruloides produced 67.5% of lipids after 134 h 4 .…”