Co-prevalence of Epstein–Barr virus and high-risk human papillomaviruses in Syrian women with breast cancer

Moustafa, Ala-Eddin Al; Al-Antary, Noor; Aboulkassim, Tahar; Akil, Nizar; Batist, Gerald; Yasmeen, Amber

doi:10.1080/21645515.2016.1139255

Cited by 49 publications

(76 citation statements)

References 23 publications

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“…In the patient with benign pathology infected with HPV, viral genotype 33, of oncogenic high-risk, was identified. These identified genotypes are consistent with those reported at the global level, where the most commonly detected oncogenic high-risk genotype is HPV-16 in between 20 and 90% 21,35 . When viral genotypes were grouped according to their oncogenic risk, we found that 28.57% of breast cancer patients had single infections with high-or low-risk genotypes, and 42.90% of HPV-positive patients showed coinfection with both genotype groups.…”

Section: Discussionsupporting

confidence: 79%

“…Although EBV is frequently associated with human lymphoid neoplasms in immunosuppressed patients 18 , several studies have demonstrated that there is also a possible association between EBV and the development of malignancy epithelial cells such as breast tissue, mainly based on some observations that support this hypothesis: (i) high incidence of male breast cancer in EBV-endemic Mediterranean countries; (ii) development of EBV-associated lymphomas at the level of the breasts; and (iii) morphological similarities between breast medullary carcinomas and nasopharyngeal carcinomas 19 . The most specific evidence of an association of EBV with breast cancer has been the identification of EBV gene sequences in breast tumors 20,21 . On the other hand, the expression of EBV latent protein expression has also been assessed in breast cancer cell lines in vitro and in vivo 22 , as well as the oncogenic capacity of its viral proteins 6 .…”

Section: Introductionmentioning

confidence: 99%

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Presence of Human Papillomavirus and Epstein-Barr Virus in Breast Cancer Biopsies as Potential Risk Factors

Ladera¹,

Fernándes²,

López³

et al. 2022

GAMO

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Introduction: Breast cancer represents the leading cause of cancer-related death in the Venezuelan female population. Many risk factors favoring its appearance have been reported; however, human papillomavirus and Epstein-Barr virus have been associated in the past few decades as potential risk factors in the development of this malignancy. Objective: To detect the presence of human papillomavirus and Epstein-Barr virus in breast cancer biopsies in order to establish a possible link between infection with these viral agents and the development of this pathology. Methods: Fresh biopsies were collected from patients with breast cancer and patients with breast benign pathology attending the Hospital Universitario de Caracas for surgery. Human papillomavirus detection was made using the INNO-LIPA ® HPV Genotyping Extra commercial kit (Innogenetics), and Epstein-Barr virus genome was detected with Epstein-Barr Virus BMLF1 commercial kit (Maxim Biotech, Inc.). Results: 63.6 and 13.6% of breast cancer cases were positive for human papillomavirus and Epstein-Barr virus DNA, respectively, whereas the benign pathology samples had 4.5% positivity for each one of the viruses; 42.90% of breast cancer samples had mixed infection with low and high oncogenic risk human papillomavirus genotypes. Conclusion: We can suggest that human papillomavirus and Epstein-Barr virus are important risk factors for breast cancer; however, studies allowing for the role of these viruses in the development of the disease to be elucidated are required. (creativecommons.org/licenses/by-nc-nd/4.0/). HPV and EBV in breast cancer 104

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Presence of Human Papillomavirus and Epstein-Barr Virus in Breast Cancer Biopsies as Potential Risk Factors

Ladera¹,

Fernándes²,

López³

et al. 2022

GAMO

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“…10 On the other hand, CRC, like other human carcinomas, is characterized by a marked propensity for distant metastases which is a major cause of death in CRC patients. 11 Cancer metastasis is a multistep process that initiates with the dissemination of malignant cells from a primary tumor to colonize distant organs. This complex process involves early steps of tumor cell invasion within the microenvironment that eventually enters the bloodstream.…”

Section: Introductionmentioning

confidence: 99%

Epstein–Barr virus and its association with Fascin expression in colorectal cancers in the Syrian population: A tissue microarray study

Al-Antary

Farghaly

Aboulkassim

et al. 2017

Human Vaccines & Immunotherapeutics

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Colorectal cancer (CRC) is the third most common malignancy in both men and women worldwide. Colorectal carcinogenesis is a complex, multistep process involving environmental and lifestyle features as well as sequential genetic changes in addition to bacterial and viral infections. Viral infection has a proven role in the incidence of approximately 20% of human cancers including gastric malignancies. Accordingly, Epstein-Barr virus (EBV) has been recently shown to be present in human gastric cancers, which could play an important role in the initiation and progression of these cancers. Therefore, this work explores the prevalence of EBV in 102 CRC tissues from the Syrian population using polymerase chain reaction (PCR) and tissue microarray (TMA) analysis. We found that EBV is present in 37 (36.27%) of CRC samples. Additionally, the expression of LMP1 onco-protein of EBV was found to be correlated with Fascin expression/overexpression in the majority of CRC tissue samples, which are intermediate/high grade invasive carcinomas. Our data indicate that EBV is present in CRC and its presence is associated with more aggressive cancer phenotype. Consequently, future investigations are needed to expose the role of EBV in CRC initiation and progression.

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“…En la paciente con patología benigna infectada por el VPH se identificó el genotipo 33, de alto riesgo oncogénico. Estos genotipos identificados coinciden con los reportados en el resto del mundo, donde el genotipo de alto riesgo oncogénico más frecuentemente detectado es el 16, en un 20 a un 90% de los casos 21,35 . Agrupando los genotipos virales según su riesgo oncogé-nico, obtuvimos que el 28.57% de las pacientes con cáncer de mama presentó infección única por genotipos de alto y bajo riesgo, respectivamente, y el 42.90% de las pacientes positivas para VPH presentó coinfección por ambos grupos de genotipos.…”

Section: Discussionunclassified

“…A pesar de que el VEB se asocia con frecuencia con neoplasias linfoides humanas en pacientes inmunosuprimidos 18 , diversos estudios han demostrado que también existe una posible asociación con el desarrollo de malignidad en células epiteliales, como el tejido mamario, basándose principalmente en algunas observaciones que sustentan esta hipótesis: 1) la alta incidencia de cáncer de mama masculino en países del mediterráneo endémicos de VEB; 2) el desarrollo de linfomas asociados al VEB en las mamas; y 3) las similitudes morfológicas entre los carcinomas medulares de mama y los carcinomas nasofaríngeos 19 . La evidencia más específica de la asociación del VEB con el cáncer de mama ha sido la identificación de secuencias génicas del virus dentro de tumores mamarios 20,21 . Por otra parte, también se ha evaluado la expresión de proteínas latentes del VEB en líneas celulares de cáncer de mama in vitro e in vivo 22 , así como también la capacidad oncogénica de sus proteínas virales 6 .…”

Section: Introductionunclassified

Presencia del virus del papiloma humano y del virus de Epstein-Barr en biopsias de cáncer de mama como posibles factores de riesgo

Ladera

Fernándes

López

et al. 2022

GAMO

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Recibido el 8 de octubre de 2016; aceptado el 25 de febrero de 2017 Disponible en Internet el 4 de agosto de 2017Resumen Introducción: El cáncer de mama en Venezuela representa la primera causa de muerte oncológica en la población femenina. Se han reportado muchos factores de riesgo que favorecen su aparición; sin embargo, en las últimas décadas el virus del papiloma humano (VPH) y el virus de Epstein-Barr (VEB) se han asociado como posibles factores de riesgo en el desarrollo de esta malignidad. Objetivo: Detectar la presencia de VPH y VEB en biopsias de cáncer de mama, para establecer una posible relación entre la infección por estos agentes virales y el desarrollo de esta patología. Métodos: Se recolectaron biopsias frescas de pacientes con cáncer de mama y de pacientes con patología benigna de la mama, que asistieron a cirugía en el Hospital Universitario de Caracas. Se realizaron la detección y la tipificación de VPH mediante el estuche comercial INNOLIPA ® HPV Genotyping Extra (Innogenetics), y se detectó el genoma del VEB mediante el estuche comercial Epstein-Barr virus BMLF1 (Maxim Biotech, Inc.). Resultados: El 63,6 y el 13,6% de los casos de cáncer de mama fueron positivos para ADN de VPH y VEB, respectivamente, mientras que las muestras de patología benigna presentaron un 4,5% de positividad para cada uno de los virus. El 42,9% de las muestras de cáncer de mama presentó infección mixta con genotipos de alto y bajo riesgo oncogénico de VPH. Conclusión: Podemos sugerir que el VPH y el VEB representan importantes factores de riesgo para el cáncer de mama, pero son necesarios estudios que permitan dilucidar mejor el papel de estos virus en el desarrollo de la enfermedad. (creativecommons.org/licenses/by-nc-nd/4.0/).

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Co-prevalence of Epstein–Barr virus and high-risk human papillomaviruses in Syrian women with breast cancer

Cited by 49 publications

References 23 publications

Presence of Human Papillomavirus and Epstein-Barr Virus in Breast Cancer Biopsies as Potential Risk Factors

Presence of Human Papillomavirus and Epstein-Barr Virus in Breast Cancer Biopsies as Potential Risk Factors

Epstein–Barr virus and its association with Fascin expression in colorectal cancers in the Syrian population: A tissue microarray study

Presencia del virus del papiloma humano y del virus de Epstein-Barr en biopsias de cáncer de mama como posibles factores de riesgo

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