Co-precipitation of trans -resveratrol in PHBV using Solution Enhanced Dispersion by Supercritical Fluids technique

Magro, Camila Dal; Aguiar, Gean Pablo S.; Veneral, Josamaique G.; Santos, Aline Elias dos; Chaves, Lorenzo M.P.C.; Oliveira, J. Vladimir; Lanza, Marcelo

doi:10.1016/j.supflu.2017.03.025

Cited by 36 publications

(8 citation statements)

References 35 publications

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“…Unprocessed RSV depicts many sharp peaks diffractions at approximately 2θ = 6°, 16°, 19°, 22°, 23.5° and 28°, whereas unprocessed GA depicts the main sharp peaks at approximately 2θ = 8°, 12°, 16° and 19°, confirming the crystalline state of both raw compounds. RSV and GA patterns agree with the literature [ 45 , 46 ].…”

Section: Resultssupporting

confidence: 91%

Dry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-Drying

et al. 2022

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Every year, grapevine pruning produces huge amounts of residue, 90% of which are from vine shoots. These are a rich source of natural antioxidants, mostly phenolic compounds, which, when properly extracted, can give rise to added-value products. However, their lack of solubility in aqueous media and high susceptibility to thermal and oxidative degradation highly limit their bioavailability. Encapsulation in suitable carriers may have a positive impact on their bioavailability and bioactivity. Previous data on vine-shoot extraction have identified gallic acid (GA) and resveratrol (RSV) as the main phenolic compounds. In this work, model dry powder formulations (DPFs) of GA and RSV using hydroxypropyl cellulose (HPC) as carriers were developed using Supercritical CO2-Assisted Spray Drying (SASD). A 32 full factorial Design of Experiments investigated the solid and ethanol contents to ascertain process yield, particle size, span, and encapsulation efficiency. Amorphous powder yields above 60%, and encapsulation efficiencies up to 100% were achieved, representing excellent performances. SASD has proven to be an efficient encapsulation technique for these phenolic compounds, preserving their antioxidation potential after three months in storage with average EC50 values of 30.6 µg/mL for GA–DPFs and 149.4 µg/mL for RSV–DPF as assessed by the scavenging capacity of the DPPH radical.

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Section: Resultssupporting

confidence: 91%

Dry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-Drying

et al. 2022

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“…Residual solvent analysis performed by GC-MS and GC-FID showed the presence of 21.75 ppm of dichloromethane in the particles, while the acetone residue was lower than the limit of the instrument used, i.e., < 1 ppm. Such results are in agreement with regulatory agencies -The National Agency for Sanitary Vigilance -ANVISA Brazil, Pharmacopoeia of the People's Republic of China, European Pharmacopoeia and International Conference on Harmonization (ICH), document Q3C (R5) from 2011, that establish the maximum concentration for human consumption at 600 ppm for dichloromethane and 5000 ppm for acetone (Aguiar et al, 2016, Dal Magro et al, 2017. Aguiar et al (2016), using the SEDS technique in the micronization process of resveratrol, obtained residual solvent dichloromethane and acetone between 50-80 ppm.…”

Section: Identification and Quantification Of Residual Solventsupporting

confidence: 87%

Poly(hydroxybutyrate-Co-Hydroxyvalerate) Micronization by Solution Enhanced Dispersion by Supercritical Fluids Technique

Aguiar

Magro

Oliveira

et al. 2018

Braz. J. Chem. Eng.

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Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a biodegradable polymer used for a wide range of applications, especially in biomedical and food industry, for which bioactive compound encapsulation is noteworthy. This work aimed to micronize PHBV by Solution Enhanced Dispersion by Supercritical Fluids technique and evaluate possible changes in polymer crystallinity. A 2 3 Central Composite Design with 3 central points was used to analyze the influence of pressure, temperature and PHBV concentration on particle size produced. Micronized particles were mostly spherical with sizes from 210 to 720 nm, and free of organic solvents. PHBV crystallinity degree was approximately 20% higher when polymer was processed at 8 MPa compared to that processed at 10 and 12 MPa, as well as to the raw polymer. Results suggest versatility in PHBV application according to SEDS process parameters and the possibility of its use in drug delivery systems.

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“…The SEDS experimental equipment and procedure used to micronize curcumin with supercritical carbon dioxide (CO 2 ) as an anti-solvent was described in detail in previous studies (Dal Magro et al, 2017; Machado et al, 2014). A schematic diagram of the experimental apparatus is presented in Figure 1.…”

Section: Methodsmentioning

confidence: 99%

Curcumin micronization by supercritical fluid:in vitroandin vivobiological relevance

Sachett

Gallas‐Lopes

Benvenutti

et al. 2021

Preprint

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Curcumin, a polyphenol extracted from the rhizome of Curcuma longa L. (Zingiberaceae), is shown to have antioxidant, anti-inflammatory, neuroprotective, anxiolytic, and antidepressant properties in both preclinical and clinical studies. However, its low bioavailability is a limitation for its potential adoption as a therapeutic agent. The process of micronization can overcome this barrier by reducing the particle size and increasing the dissolution rate, potentially improving the bioavailability of the compounds of interest. In this study, we compared the in vitro antioxidant effects of curcumin (CUR) and micronized curcumin (MC) and studied their effects on behavioral and neurochemical parameters in zebrafish submitted to unpredictable chronic stress (UCS). MC (1 g/L) presented higher antioxidant activity in vitro as compared to CUR, as measured by iron-reducing antioxidant power (FRAP), 1,1-diphenyl-2-2-picyryl-hydrazyl radical removal (DPPH), and deoxyribose tests. UCS increased total distance traveled in the social interaction test (SI), while decreased crossings, time, and entries to the top area in the novel tank test (NTT). No effects of UCS were observed in the open tank test (OTT). The behavioral effects induced by UCS were not blocked by any curcumin preparation. UCS also decreased non-protein thiols (NPSH) levels, while increased glutathione reductase (GR) activity and thiobarbituric acid reactive substances (TBARS) levels on zebrafish brain. MC presented superior antioxidant properties than CUR in vivo, blocking the stress-induced neurochemical effects. Although this study did not measure the concentration of curcumin on the zebrafish brain, our results suggest that micronization increases the bioavailability of curcumin, potentiating its antioxidant activity both in vitro and in vivo. Our study also demonstrates that counteracting the oxidative imbalance induced by UCS is not sufficient to block its behavioral effects.

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Co-precipitation of trans -resveratrol in PHBV using Solution Enhanced Dispersion by Supercritical Fluids technique

Cited by 36 publications

References 35 publications

Dry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-Drying

Dry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-Drying

Poly(hydroxybutyrate-Co-Hydroxyvalerate) Micronization by Solution Enhanced Dispersion by Supercritical Fluids Technique

Curcumin micronization by supercritical fluid:in vitroandin vivobiological relevance

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