Co-pigmentation of strawberry anthocyanins with phenolic compounds from rooibos

Erşan, Sevcan; Müller, Max; Reuter, Luise; Carle, Reinhold; Müller-Maatsch, Judith

doi:10.1016/j.fochms.2022.100097

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…A copigmentation reaction is one of the most valid and enforceable methods to enhance the stability of anthocyanins through noncovalent bonds. , The copigmentation effects of the obtained lignan extracts on P3G-enriched anthocyanins were assessed according to UV/vis spectra in the range of 400–700 nm. As shown in Figure A–D, the absorbance increased as the concentration of lignan extracts increased, suggesting that the introduction of these lignan extracts can also make the anthocyanin extracts more stable and produce considerable hyperchromic effects. − By comparison, S. sphenathera fruit extracts (WSS and ESS) had stronger copigmentation effects than S.…”

Section: Resultsmentioning

confidence: 96%

Color-Stabilizing Effects and Mechanisms of Schisandra Lignans on the Anthocyanins Enriched with Petunidin-3-O-glucoside

Dai

Zhao

et al. 2023

ACS Food Sci. Technol.

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This study systematically explored the copigmentation effects of lignan extracts, lignan eluent fractions, and individual lignans from Schisandra sphenathera and Schisandra chinensis fruits on the anthocyanins enriched with petunidin-3-O-glucoside. The results showed that two ethanol extracts contained higher levels of lignans and were more effective in copigmentation reactions than their water counterparts. The isolation of ethanol extracts on macroporous resin rendered a large proportion of lignans enriched in 95% EtOH eluent fractions, one of which from S. sphenathera exhibited the strongest ability to stabilize the color. Meanwhile, correlational analyses suggested that six lignans, namely, schisandrol A, schisandrol B, schisantherin A, schisantherin B, schisandrin A, and schisandrin B, were the major active copigments that thermodynamically stabilize the target anthocyanins, with schisandrin B being the best one. Moreover, the structure–function relationships of these compounds revealed that the biaryl backbone was essential for copigmentation, which can be enhanced by the aromatic methylenedioxy groups.

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Section: Resultsmentioning

confidence: 96%

Color-Stabilizing Effects and Mechanisms of Schisandra Lignans on the Anthocyanins Enriched with Petunidin-3-O-glucoside

Dai

Zhao

et al. 2023

ACS Food Sci. Technol.

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“…Current studies on orientin were animal studies [83,84], therefore the pain alleviation efect and side efect on humans are unknown. Fortunately, the structure of orientin is similar to luteolin [85], while luteolin has been tested in many clinical trials. Luteolin is efective in pain inhibition [81], with above 5,000 mg/kg LD50 values in rats [86], and safe in pediatric patients [87].…”

Section: Discussionmentioning

confidence: 99%

Orientin Reduces the Effects of Repeated Procedural Neonatal Pain in Adulthood: Network Pharmacology Analysis, Molecular Docking Analysis, and Experimental Validation

Guo,

Huang,

Liu

et al. 2023

Pain Research and Management

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Background. Premature infants often undergo painful procedures and consequently experience repeated procedural neonatal pain. This can elicit hyperalgesia and cognitive impairment in adulthood. Treatments for neonatal pain are limited. Orientin is a flavonoid C-glycoside that has repeatedly been shown to have pharmacological effects in the past decades. The aim of this study was to systematically explore the effect of orientin on repeated procedural neonatal pain using network pharmacology, molecular docking analysis, and experimental validation. Methods. Several compound-protein databases and disease-protein databases were employed to identify proteins that were both predicted targets of orientin and involved in neonatal pain. A protein-protein interaction (PPI) network was constructed, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to explore the potential mechanism of action. Molecular docking analysis was employed to calculate the binding energy and visualize the interactions between orientin and potential target proteins. Finally, a mouse model of repeated procedural neonatal pain was established and orientin was administered for 6 days. The mechanical and thermal pain thresholds were assessed in neonates and adult mice. A Morris water maze was employed to investigate cognitive impairment in adult mice. Results. A total of 286 proteins that were both predicted targets of orientin and involved in neonatal pain were identified. The hub proteins were SRC, HSP90AA1, MAPK1, RHOA, EGFR, AKT1, PTPN11, ESR1, RXRA, and HRAS. GO analysis indicated that the primary biological process (BP), molecular function (MF), and cellular component (CC) were protein phosphorylation, protein kinase activity, and vesicle lumen, respectively. KEGG analysis revealed that the mitogen-activated protein kinase (MAPK) signaling pathway may be the key to the mechanism of action. Molecular docking analysis showed the high binding affinities of orientin for MAPK1, MAPK8, and MAPK14. In mice, orientin inhibited the hyperalgesia in the pain threshold tests in neonates and adult mice and cognitive impairment in adult mice. Immunofluorescence showed that phosphorylated MAPK1 (p-ERK) protein levels in the hippocampus and spinal dorsal horn were downregulated by orientin. Conclusion. The findings suggested that orientin alleviates neonatal pain, and the MAPK signaling pathway is involved.

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Natural Variation in the Phenolic Composition of Rooibos and Changes During Production of Herbal Tea and Other Products

Joubert

Human

Beer

2023

Reference Series in Phytochemistry

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Co-pigmentation of strawberry anthocyanins with phenolic compounds from rooibos

Cited by 4 publications

References 39 publications

Color-Stabilizing Effects and Mechanisms of Schisandra Lignans on the Anthocyanins Enriched with Petunidin-3-O-glucoside

Color-Stabilizing Effects and Mechanisms of Schisandra Lignans on the Anthocyanins Enriched with Petunidin-3-O-glucoside

Orientin Reduces the Effects of Repeated Procedural Neonatal Pain in Adulthood: Network Pharmacology Analysis, Molecular Docking Analysis, and Experimental Validation

Natural Variation in the Phenolic Composition of Rooibos and Changes During Production of Herbal Tea and Other Products

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