1985
DOI: 10.1016/0006-291x(85)90631-x
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Co-oxidation of luminol by hypochlorite and hydrogen peroxide implications for neutrophil chemiluminescence

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Cited by 113 publications
(57 citation statements)
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“…Activation of cells by ionophore induces the mobilization of intracellular Ca 2+ ions and flux of extracellular Ca z+ ions into the cytoplasm across the cellular membranes which are essential to the function and maintenance of the cell (Allan et al, 1976;Raval & Allan, 1985;Truneh et al, 1985). Recent evidence suggests that Ca 2+ ion mobilization and protein kinase C (PKC) (Fujita et al, 1984;Nishizuka, 1984) are activators of the superoxide anion (Ok) critical to the microbiocidal action of PMN (Brestel, 1985). The production of Oj and subsequent CL is the result of the activation of the membrane-bound NADPH/NADH oxidase (for review, see Nishizuka, 1984) by PKC and Ca 2+ mobilization.…”
Section: Discussionmentioning
confidence: 99%
“…Activation of cells by ionophore induces the mobilization of intracellular Ca 2+ ions and flux of extracellular Ca z+ ions into the cytoplasm across the cellular membranes which are essential to the function and maintenance of the cell (Allan et al, 1976;Raval & Allan, 1985;Truneh et al, 1985). Recent evidence suggests that Ca 2+ ion mobilization and protein kinase C (PKC) (Fujita et al, 1984;Nishizuka, 1984) are activators of the superoxide anion (Ok) critical to the microbiocidal action of PMN (Brestel, 1985). The production of Oj and subsequent CL is the result of the activation of the membrane-bound NADPH/NADH oxidase (for review, see Nishizuka, 1984) by PKC and Ca 2+ mobilization.…”
Section: Discussionmentioning
confidence: 99%
“…29 Buffer solutions with different pHs were prepared by mixing the same concentrated acidic and basic forms until the required pH was obtained.…”
Section: Methodsmentioning
confidence: 99%
“…The combination of HOCl and H202 significantly increases the C1 from luminol over that with H202 generating systems alone. Moreover, OH-, 02-, and '02 do not seem critical to the production of luminol CL by HOCl with H202 (20). The major alternative source to oxidase generated oxygen radicals and peroxidase products would be Fig.…”
Section: Discussionmentioning
confidence: 96%