Co-occurrence of multidrug resistance, β-lactamase and plasmid mediated AmpC genes in bacteria isolated from river Ganga, northern India

Chaturvedi, Preeti; Chaurasia, Deepshi; Pandey, Ashok; Gupta, Pratima

doi:10.1016/j.envpol.2020.115502

Cited by 26 publications

(11 citation statements)

References 52 publications

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“…Penicillinase, first described in 1940, belonged to class C and is now known as AmpC present in Escherichia coli (Abraham and Chain, 1940). The literature mostly mentions the beta-lactamases originating from microorganisms possessing AmpC, including MIR, DHA, ACC, MOX, EBC, and FOX types, with the CMY-2 subtype being the most widespread one of them (Nikonorow et al, 2013;Chaturvedi et al, 2020). Many of the class A and D beta-lactamases are classified as extendedspectrum beta-lactamases (ESBLs) such as TEM, SHV, and CTX-M which are among the most abundant ESBLs worldwide.…”

Section: Introductionmentioning

confidence: 99%

Impact of Hospital Wastewater on the Occurrence and Diversity of Beta-Lactamase Genes During Wastewater Treatment with an Emphasis on Carbapenemase Genes: A Metagenomic Approach

Hubeny

Ciesielski

Harnisz

et al. 2021

Front. Environ. Sci.

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The diversity of beta-lactam antibiotic resistance genes, with particular emphasis on carbapenemase genes, during the treatment process at two wastewater treatment plants (WWTPs) with different levels of hospital wastewater inflow was investigated using high-throughput sequencing. An additional aspect of the study was to determine the taxonomic diversity of microorganisms in the studied samples. The obtained results suggest that bacteria of the Fusobacteriaceae family, not associated to date with this phenomenon, may be involved in the spread of antibiotic resistance in the environment. In samples from both wastewater treatment plants, the dominant beta-lactamase genes included blaOXA, blaGES, blaBEL, blaCfxA, and blaTEM. It is worth noting that the blaKPC and blaNDM genes were only found in untreated municipal wastewater with a higher hospital wastewater content. Moreover, an increase in the abundance of the blaIMP gene after the biological treatment stage in the studied treatment plants was found. In wastewater characterized by a higher proportion of hospital wastewater, 94 correlations were observed, while in wastewater with its lower proportion, 41 correlations were noted. Considering the above, the current research indicates that the inflow of hospital wastewater contributes to the spread of antibiotic resistance in the aquatic environment.

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Section: Introductionmentioning

confidence: 99%

Impact of Hospital Wastewater on the Occurrence and Diversity of Beta-Lactamase Genes During Wastewater Treatment with an Emphasis on Carbapenemase Genes: A Metagenomic Approach

Hubeny

Ciesielski

Harnisz

et al. 2021

Front. Environ. Sci.

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“…S13, confirms the same result. Au/ND/C 3 N 4 substrate has the highest EF of 6.67×10 6 , which is 2.01 and 1.58 times of that Au NPs (3.32×10 6 ) and Au/C 3 N 4 (4.21×10 6 ) substrates, respectively.…”

Section: Fabrication and Characterizationmentioning

confidence: 93%

“…From 2000 to 2015, global per-capita consumption of Watch antibiotics experienced a huge increase of 90.9%, and Access antibiotics featured an increase of 26.2% [4]. As an emerging category of pollutants, antibiotics residues in wastewater could induce the emergence of multi-drug resistance (MDR) microbes, antibiotic resistant bacteria (ARB) and antibiotic resistant genes (ARGs) [5,6]. Bacteria bred by antibiotic residues may sneak into human body and trigger life-threatening infections.…”

Section: Introductionmentioning

confidence: 99%

Highly-sensitive SERS detection of tetracycline: Sub-enhancement brought by light scattering of nano-diamond

Pei

Tian

et al. 2023

Applied Surface Science

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“…Escherichia coli and other Gram-negative bacteria resistant to β-lactams, flouroquinolones, tetracyclines and other classes of antibiotics have been reported from wastewaters, river waters and wastewater treatment plants from different states of India along with co-prevalence of ESBL genotypes and other Class A β-lactamases including bla CTX-M-15 , bla CTX-M-152 , bla CTX-M-205, bla SHV and bla TEM ( Bajaj et al, 2015 ; Hanna et al, 2020 ). Environmental monitoring revealed the presence of bacteria resistant to multiple antibiotics as well as bla CTX-M, bla TEM , bla SHV and other β-lactamase genotypes in water of river Ganga, Gomti, Yamuna and Hindon ( Chaturvedi et al, 2020 , 2021 ). The scientific data on the prevalence of antibiotic-resistant Gram-negative bacteria from irrigation-purpose wastewaters are either limited or lacking from Himachal Pradesh.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of antibiotic-resistant Gram-negative bacteria having extended-spectrum β-lactamase phenotypes in polluted irrigation-purpose wastewaters from Indian agro-ecosystems

Avatsingh,

Sharma,

Kour

et al. 2023

Front. Microbiol.

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Antibiotic resistance in bacteria has emerged as a serious public health threat worldwide. Aquatic environments including irrigation-purpose wastewaters facilitate the emergence and transmission of antibiotic-resistant bacteria and antibiotic resistance genes leading to detrimental effects on human health and environment sustainability. Considering the paramount threat of ever-increasing antibiotic resistance to human health, there is an urgent need for continuous environmental monitoring of antibiotic-resistant bacteria and antibiotic resistance genes in wastewater being used for irrigation in Indian agro-ecosystems. In this study, the prevalence of antibiotic resistance in Gram-negative bacteria isolated from irrigation-purpose wastewater samples from Sirmaur and Solan districts of Himachal Pradesh was determined. Bacterial isolates of genera Escherichia, Enterobacter, Hafnia, Shigella, Citrobacter, and Klebsiella obtained from 11 different geographical locations were found to exhibit resistance against ampicillin, amoxyclav, cefotaxime, co-trimoxazole, tobramycin, cefpodoxime and ceftazidime. However, all the isolates were sensitive to aminoglycoside antibiotic gentamicin. Enterobacter spp. and Escherichia coli showed predominance among all the isolates. Multidrug-resistance phenotype was observed with isolate AUK-06 (Enterobacter sp.) which exhibited resistant to five antibiotics. Isolate AUK-02 and AUK-09, both E. coli strains showed resistant phenotypes to four antibiotics each. Phenotypic detection revealed that six isolates were positive for extended-spectrum β-lactamases which includes two isolates from Enterobacter spp. and E. coli each and one each from Shigella sp. and Citrobacter sp. Overall, the findings revealed the occurrence of antibiotic resistant and ESBL-positive bacterial isolates in wastewaters utilized for irrigation purpose in the study area and necessitate continuous monitoring and precautionary interventions. The outcomes of the study would be of significant clinical, epidemiological, and agro-environmental importance in designing effective wastewater management and environmental pollution control strategies.

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Co-occurrence of multidrug resistance, β-lactamase and plasmid mediated AmpC genes in bacteria isolated from river Ganga, northern India

Cited by 26 publications

References 52 publications

Impact of Hospital Wastewater on the Occurrence and Diversity of Beta-Lactamase Genes During Wastewater Treatment with an Emphasis on Carbapenemase Genes: A Metagenomic Approach

Impact of Hospital Wastewater on the Occurrence and Diversity of Beta-Lactamase Genes During Wastewater Treatment with an Emphasis on Carbapenemase Genes: A Metagenomic Approach

Highly-sensitive SERS detection of tetracycline: Sub-enhancement brought by light scattering of nano-diamond

Prevalence of antibiotic-resistant Gram-negative bacteria having extended-spectrum β-lactamase phenotypes in polluted irrigation-purpose wastewaters from Indian agro-ecosystems

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