Co‐occurrence of immune‐mediated conditions and endometriosis among adolescents and adult women

Shafrir, Amy; Palmor, Marissa; Fourquet, Jessica; DiVasta, Amy D.; Farland, Leslie V.; Vitonis, Allison F.; Harris, Holly R.; Laufer, Marc R.; Cramer, Daniel W.; Terry, Kathryn L.

doi:10.1111/aji.13404

Cited by 27 publications

(21 citation statements)

References 36 publications

(49 reference statements)

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“…Considering that endometriosis was reported to involve Th1/Th2 immune responses, 4–6 other type 1 allergies might also be associated with endometriosis. However, to the best of our knowledge, only two case‐control studies in the 1980s and a cross‐sectional study from the United States investigated this association 24 . In the present study, we found a slightly higher incidence of endometriosis in patients with allergic rhinitis, allergic conjunctivitis, and urticaria, whereas the association was not significant for atopic dermatitis.…”

Section: Discussioncontrasting

confidence: 57%

“…Previous studies of the association between allergic or autoimmune diseases and endometriosis have reported inconsistent results 17–24 . In a cross‐sectional study by Sinaii et al 17 autoimmune diseases (RA, SLE), allergies and asthma were more common in women with endometriosis than in the general population.…”

Section: Introductionmentioning

confidence: 97%

“…[17][18][19][20][21][22][23][24] In a cross-sectional study by Sinaii et al 17 autoimmune diseases (RA, SLE), allergies and asthma were more common in women with endometriosis than in the general population. Another cross-sectional study by Shafrir et al 24 showed positive association between autoimmune or inflammatory diseases among adolescents and adult women. In a cohort study, Peng et al 21 reported a higher risk of endometriosis in women with asthma.…”

Section: Introductionmentioning

confidence: 99%

“…[14][15][16] Previous studies of the association between allergic or autoimmune diseases and endometriosis have reported inconsistent results. [17][18][19][20][21][22][23][24] In a cross-sectional study by Sinaii et al 17 autoimmune diseases (RA, SLE), allergies and asthma were more common in women with endometriosis than in the general population. Another cross-sectional study by Shafrir et al 24 showed positive association between autoimmune or inflammatory diseases among adolescents and adult women.…”

Section: Introductionmentioning

confidence: 99%

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Association between allergic or autoimmune diseases and incidence of endometriosis: A nested case‐control study using a health insurance claims database

Yoshii

Yamana

Ono

et al. 2021

American J Rep Immunol

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Problem Immune responses were reported to be associated with the pathogenesis of endometriosis. However, previous studies of an association between allergic or autoimmune diseases and endometriosis have reported inconsistent results. We investigated the association between allergic or autoimmune diseases and the incidence of endometriosis. Method of study Using a large‐scale health insurance claims database in Japan, we identified patients with endometriosis diagnosed between April 2011 and August 2018. For each case, we identified up to four controls with the same age and registration month. Conditional logistic regression analyses were conducted to evaluate the incidence rate ratio (IRR) of endometriosis in women with allergic diseases (asthma, allergic rhinitis, urticaria, atopic dermatitis, allergic conjunctivitis, and type 1 allergies combined), systemic lupus erythematosus, and rheumatoid arthritis compared with women without these diseases. Results We identified 30 516 cases with endometriosis and 120 976 control participants. Mean age at registration was 30 years. There were significant positive associations between type 1 allergy and endometriosis (IRR, 1.10; 95% confidence interval, 1.06–1.13) and between rheumatoid arthritis and endometriosis (IRR, 1.31; 95% confidence interval, 1.05–1.64). Diagnosis of systemic lupus erythematosus was not associated with increased incidence of endometriosis. Among the different allergic diseases, allergic rhinitis, urticaria, and allergic conjunctivitis were associated with the increased incidence. Conclusion Several allergic diseases were associated with an increased incidence of endometriosis. A higher incidence was also observed in patients with rheumatoid arthritis. Further studies are warranted to elucidate the influence of immune responses on the development of endometriosis.

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Section: Discussioncontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between allergic or autoimmune diseases and incidence of endometriosis: A nested case‐control study using a health insurance claims database

Yoshii

Yamana

Ono

et al. 2021

American J Rep Immunol

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“…A case-control study of 150 women with endometriosis, SLE, celiac disease, inflammatory bowel disease, and autoimmune thyroiditis was more frequent in those with endometriosis [4]. Another case-control study demonstrated an increasing number of immune-mediated conditions and co-occurring endometriosis [5]. A nationwide population-based study showed an increased risk of RA in patients with endometriosis during more than 10-year follow-up [6].…”

Section: Endometriosis and Autoimmune Diseasesmentioning

confidence: 98%

Endometriosis and autoimmunity

et al. 2022

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Endometriosis is an inflammatory oestrogen-dependent chronic disease and is mainly expressed by pain and increased infertility. Several studies showed an increased prevalence of autoimmune systemic diseases and various autoantibodies in endometriosis. The association of these autoimmune markers and diseases could raise the fact that endometriosis is an authentic autoimmune or inflammatory disease and thus could argue for the use of immunomodulatory therapies. Usually, it is considered that the autoantibodies did not directly act in endometrium implants growth, and could be rather implicated in endometriosis-related infertility. The use of immunomodulatory strategies could be an important alternative or additional strategy to the use of hormones and surgery but need prospective well-designed trials.

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Genomic characterisation of the overlap of endometriosis with 76 comorbidities identifies pleiotropic and causal mechanisms underlying disease risk

2023

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Comorbid conditions can be driven by underlying pleiotropic and causal mechanisms that can provide insights into shared molecular and biological processes contributing to disease risk. Endometriosis is a chronic condition affecting one in nine women of reproductive age and poses many challenges including lengthy diagnostic delays and limited treatment efficacy owing to poor understanding of disease aetiology. To shed light on the underlying biological mechanisms and to identify potential risk factors, we examine the epidemiological and genomic relationship between endometriosis and its comorbidities. In the UK Biobank 292 ICD10 codes were epidemiologically correlated with endometriosis diagnosis, including gynaecological, immune, infection, pain, psychiatric, cancer, gastrointestinal, urinary, bone and cardiovascular traits. A subset of the identified comorbidities (n = 76) underwent follow-up genetic analysis. Whilst Mendelian randomisation suggested causality was not responsible for most comorbid relationships, 22 traits were genetically correlated with endometriosis, including pain, gynaecological and gastrointestinal traits, suggestive of a shared genetic background. Pleiotropic genetic variants and genes were identified using gene-based and colocalisation analysis. Shared genetic risk factors and potential target genes suggest a diverse collection of biological systems are involved in these comorbid relationships including coagulation factors, development of the female reproductive tract and cell proliferation. These findings highlight the diversity of traits with epidemiological and genomic overlap with endometriosis and implicate a key role for pleiotropy in the comorbid relationships.

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Co‐occurrence of immune‐mediated conditions and endometriosis among adolescents and adult women

Cited by 27 publications

References 36 publications

Association between allergic or autoimmune diseases and incidence of endometriosis: A nested case‐control study using a health insurance claims database

Association between allergic or autoimmune diseases and incidence of endometriosis: A nested case‐control study using a health insurance claims database

Endometriosis and autoimmunity

Genomic characterisation of the overlap of endometriosis with 76 comorbidities identifies pleiotropic and causal mechanisms underlying disease risk

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