Co-occurrence of high-frequency oscillations and delayed responses evoked by intracranial electrical stimulation in stereo-EEG studies

Donos, Cristian; Mı̂ndruță, Ioana; Mălîia, Mihai Dragoş; Raşină, Alin; Ciurea, Jean; Barborică, Andrei

doi:10.1016/j.clinph.2016.11.028

Cited by 10 publications

(10 citation statements)

References 41 publications

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“…Epileptic cortex has been identified using delayed responses (DRs), which occur between 0.1 and 1s after stimulation, when using a stimulation frequency of 0.1 Hz. A correlation was also found between DRs and HFOs . HFOs have also been detected using 0.2 Hz stimulation and correlated with the EZ .…”

Section: Physical Stimulation Considerationsmentioning

confidence: 62%

“…Furthermore, CCEP stimulation has novel applications to reveal potential biomarkers of epileptogenicity, specifically high‐frequency oscillations (HFOs),during stimulation of epileptic tissue. To define the epileptogenic zone, several studies have also employed this technique (Tables and ). Although there are numerous uses for CCEPs, the precise methodology remains relatively undocumented, largely because of center‐specific customized techniques in both performing and analyzing CCEP responses.…”

Section: Introductionmentioning

confidence: 99%

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Considerations in performing and analyzing the responses of cortico‐cortical evoked potentials in stereo‐EEG

2017

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SummaryThis review aims to highlight key considerations when performing cortico-cortical evoked potentials (CCEPs) using stereo-electroencephalography (SEEG) for network mapping and show its clinical applicability to presurgical evaluations. The parameters for performing stimulation and safety aspects have been investigated in electrocorticography (ECoG) and deep brain stimulation (DBS), but not as extensively in SEEG. A review of current literature was performed, with an attempt made to emphasize practical insights from all modalities of intracranial stimulation. This paper reviews physical stimulation parameters, highlights safety limits, and considers the influence of changing common stimulation parameters.These factors are put into the context of CCEPs in SEEG. Given the paucity of direct research in this area, studies utilizing low frequency stimulation, DBS, and ECoG are incorporated along with the fundamental principles of electrical engineering. In addition, postprocessing considerations are reviewed, including electrode localization, application of digital filters, baseline selection, application of connectivity metrics, and higher order network analysis. The aim is to guide CCEP stimulation as well as to provide an understanding of the underlying principles of this technique. At present, there are few articles detailing the design of low-frequency stimulation paradigms, especially in the setting of SEEG. Providing a review of the fundamentals and postprocessing considerations when performing CCEPs in SEEG will increase the accessibility of this technique. K E Y W O R D Sbrain mapping, CCEP, connectivity, electrical stimulation, review, SEEG

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Section: Physical Stimulation Considerationsmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Considerations in performing and analyzing the responses of cortico‐cortical evoked potentials in stereo‐EEG

2017

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“…19 The slow early components of CCEPs, which are only considered here, are thought to be less affected by the pathology than the late ones, even for stimulating or recording electrode contacts located in either the epileptogenic or the propagation zone. 20,21 However, to minimize a potential bias in our findings due to epileptogenic processes, we removed from our analysis the data recorded by electrode contacts suspected to present a pathological activity. To do so in an unsupervised manner, we computed the interictal spiking rate of each contact from prestimulation period recordings using Delphos software (Detector of Electro Physiological Oscillations and Spikes) 22,23 .…”

Section: Processing and Selection Of Ccepsmentioning

confidence: 99%

A brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials

Lemaréchal

Jedynak

Trébaul

et al. 2021

Brain

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Epilepsy presurgical investigation may include focal intracortical single-pulse electrical stimulations with depth electrodes, which induce cortico-cortical evoked potentials (CCEP) at distant sites because of white matter connectivity. CCEPs provide a unique window on functional brain networks because they contain sufficient information to infer dynamical properties of large-scale brain connectivity, such as preferred directionality and propagation latencies. Here, we developed a biologically informed modelling approach to estimate the neural physiological parameters of brain functional networks from the CCEPs recorded in a large multicentric database. Specifically, we considered each CCEP as the output of a transient stimulus entering the stimulated region, which directly propagated to the recording region. Both regions were modelled as coupled neural mass models, the parameters of which were estimated from the first CCEP component, occurring before 80 ms, using dynamic causal modelling and Bayesian model inversion. This methodology was applied to the data of 780 patients with

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“…High frequency activity during the CCEP (32,33) or suppression of high-frequency activity after stimulation (34) have been investigated for their SOZ localizing power. Specifically high frequency oscillations were found to colocalize with CCEP responses (35)(36)(37), in one study as much as 40% of the time (38). Lastly, graph theoretical properties of the networks generated from CCEP response amplitudes revealed that networks are more bi-directionally connected in the SOZ than in non-SOZ regions (39)(40)(41).…”

Section: Introductionmentioning

confidence: 90%

Transfer Function Models for the Localization of Seizure Onset Zone From Cortico-Cortical Evoked Potentials

et al. 2020

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Surgical resection of the seizure onset zone (SOZ) could potentially lead to seizure-freedom in medically refractory epilepsy patients. However, localizing the SOZ can be a time consuming and tedious process involving visual inspection of intracranial electroencephalographic (iEEG) recordings captured during passive patient monitoring. Cortical stimulation is currently performed on patients undergoing invasive EEG monitoring for the main purpose of mapping functional brain networks such as language and motor networks. We hypothesized that evoked responses from single pulse electrical stimulation (SPES) can also be used to localize the SOZ as they may express the natural frequencies and connectivity of the iEEG network. To test our hypothesis, we constructed patient specific transfer function models from the evoked responses recorded from 22 epilepsy patients that underwent SPES evaluation and iEEG monitoring. We then computed the frequency and connectivity dependent “peak gain” of the system as measured by the norm from systems theory. We found that in cases for which clinicians had high confidence in localizing the SOZ, the highest peak gain transfer functions with the smallest “floor gain” (gain at which the dipped 3dB below DC gain) corresponded to when the clinically annotated SOZ and early spread regions were stimulated. In more complex cases, there was a large spread of the peak-to-floor (PF) ratios when the clinically annotated SOZ was stimulated. Interestingly for patients who had successful surgeries, our ratio of gains, agreed with clinical localization, no matter the complexity of the case. For patients with failed surgeries, the PF ratio did not match clinical annotations. Our findings suggest that transfer function gains and their corresponding frequency responses computed from SPES evoked responses may improve SOZ localization and thus surgical outcomes.

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Co-occurrence of high-frequency oscillations and delayed responses evoked by intracranial electrical stimulation in stereo-EEG studies

Cited by 10 publications

References 41 publications

Considerations in performing and analyzing the responses of cortico‐cortical evoked potentials in stereo‐EEG

Considerations in performing and analyzing the responses of cortico‐cortical evoked potentials in stereo‐EEG

A brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials

Transfer Function Models for the Localization of Seizure Onset Zone From Cortico-Cortical Evoked Potentials

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