Co-occurrence of chronic kidney disease and glaucoma: Epidemiology and etiological mechanisms

Liu, Wei; Guo, Ruru; Huang, Dandan; Ji, Jian; Gansevoort, Ron T.; Snieder, Harold; Jansonius, Nomdo M.

doi:10.1016/j.survophthal.2022.09.001

Cited by 11 publications

(7 citation statements)

References 199 publications

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“…In this regard, it has been reported that prevalence of CKD increases rapidly with age. In the USA, the CKD prevalence in adults 30 years of age or older is estimated to be 16.7% in 2030 [ 31 ]. Although the relationship between CKD and glaucoma appears to be inconsistent in population-based studies, there is some evidence that the prevalence of glaucoma is higher in patients with known CKD, with a prevalence of 7.6% [ 31 – 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the USA, the CKD prevalence in adults 30 years of age or older is estimated to be 16.7% in 2030 [ 31 ]. Although the relationship between CKD and glaucoma appears to be inconsistent in population-based studies, there is some evidence that the prevalence of glaucoma is higher in patients with known CKD, with a prevalence of 7.6% [ 31 – 33 ]. In this study we did not perform diagnostic tests for glaucoma; however, we found an association with increased IOP which is known to be the only modifiable risk factor for developing glaucoma [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Relationship Between Diabetic Macular Edema and Renal Function in a Latino Population

et al. 2023

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Introduction Diabetic macular edema (DME) is one of the leading causes of vision impairment. The relationship between DME and estimated glomerular filtration rate (eGFR) has not been clearly evaluated in Hispanic or Latino populations. The objective of this study was to evaluate the eGFR in a Latino population with DME. Methods A cross-sectional, observational, and descriptive study was carried out on the basis of a multicenter phase III clinical trial. Results A total of 82 subjects diagnosed with DME (36 women and 46 men) were included in the study. The mean age was 61.93 ± 6.71 years. Mean values of the blood chemistry parameters glycated hemoglobin and eGFR were 7.20 ± 0.95% and 74.42 ± 26.82 mL/min/1.73 m 2 , respectively. The time elapsed since diagnosis of diabetes mellitus was 15.30 ± 7.35 years, while the duration of DME was 1.41 ± 1.75 years. Mean values for central macular thickness (CMT) and total macular volume (TMV) were 440.99 ± 132.22 µm and 11.97 ± 2.11 mm 3 , respectively. DME duration had a negative correlation with TMV (Rho − 0.26, p < 0.05) and a positive correlation with mean arterial pressure (Rho 0.26, p < 0.05). CMT was correlated with TMV (Rho 0.43, p < 0.0001) and visual acuity (Rho 0.26, p < 0.05). No significant correlations were observed between eGFR and CMT, TMV, or any demographic variable ( p > 0.05). Chronic kidney disease (CKD) was associated with hypertension (OR 9.32, p = 0.035), elevated intraocular pressure (IOP) (OR 0.03, p = 0.011), and advanced age (OR 0.45, p = 0.011). CMT was significantly associated with TMV ( β = 27.69, p < 0.0001). Conclusions We did not find a correlation between eGFR and DME. Our findings suggest that the presence of hypertension is associated with a decrease in the GFR < 60 mL/min/1.73 m 2 , and CKD may be associated with advanced age and elevated IOP which may increase the risk for the development of glaucoma. Trial Registration NCT05217680 (clinicaltrials.gov). Supplementary Information The online version contains supplementary material available at 10.1007/s40123-023-00787-w.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of the Relationship Between Diabetic Macular Edema and Renal Function in a Latino Population

et al. 2023

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“…UA can be hypothesized both to be harmful (via inducing oxidative stress and provoking endothelial dysfunction) [ 3 ] and to be protective (via its antioxidant properties) [ 4 , 5 ]. Possibly in line with this, the results of various clinical and epidemiological studies on the role of UA in POAG were inconsistent, with evidence of both increased and decreased serum UA levels (for review see Liu et al [ 6 ]). Researchers from Tunis [ 7 ] and Greece [ 8 ] found that the serum UA levels of POAG patients were higher than that of controls, while lower serum UA levels in POAG patients were found in two other studies, one from China [ 9 ] and one from Italy [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Association between primary angle closure glaucoma and uric acid levels in serum and aqueous humor

Liu,

Guo,

Gao

et al. 2024

Heliyon

Self Cite

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“…While intraocular pressure has been identified as the most important risk factor for its development, other risk factors have been identified [9,10]. It has been known that female [11], older age [8,12,13], smoking [14,15], drinking [14,16], underexercising [14,17], lower BMI [14,[18][19][20], and CKD [21] increase the risk for glaucoma. Both systemic vascular factors, such as hypertension and diabetes, and ocular vascular factors, such as ocular blood flow and ocular perfusion pressure, have been identified as risk factors, emphasizing the role of vascular mechanisms in its pathophysiology [9,10,22].…”

Section: Introductionmentioning

confidence: 99%

Presence and severity of migraine is associated with development of primary open angle glaucoma: A population-based longitudinal cohort study

Ohn

Moon²,

Jung³

2023

PLoS ONE

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Purpose To examine the association between the presence and severity of migraine and development of primary open-angle glaucoma (POAG) using a nationwide population-based longitudinal cohort data. Methods Data were retrieved from the Korean National Health Insurance Service for 2,716,562 individuals aged ≥ 40 years and assessed for the development of POAG from 2009 through 2018. Subjects were classified into the following 3 groups: healthy control subjects, subjects with mild migraine, and those with severe migraine. Hazard ratios (HR) of glaucoma development were calculated for each group. Subgroup analyses of subjects stratified by age, sex, lifestyle factors (smoking, drinking, and body mass index (BMI)), and comorbidities (diabetes, hypertension, and dyslipidemia). Results During the 9-year follow-up period, the incidence rate of POAG per 1000 person-years was 2.41 and 3.25 in subjects without and with migraine, respectively. Among the migraine group, the incidence rate was 3.14 and 3.89 in mild and severe subgroups, respectively. The HR was 1.355 (95% CI, 1.300–1.412) and 1.188 (95% CI, 1.140–1.239) before and after adjusting for potential confounding factors in the migraine group per se. Regarding the severity of migraine, the adjusted HRs were 1.169 (95% CI, 1.117–1.224) in the mild migraine group, and 1.285 (95% CI, 1.166–1.415) in the severe migraine group compared to the control group. The results were consistent in subgroup analyses after stratifying by age, sex, lifestyle factors, and comorbidities. Conclusions Migraine is associated with increased risk of POAG development. Furthermore, chronic and severe migraine is associated with greater risk of POAG development.

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Co-occurrence of chronic kidney disease and glaucoma: Epidemiology and etiological mechanisms

Cited by 11 publications

References 199 publications

Evaluation of the Relationship Between Diabetic Macular Edema and Renal Function in a Latino Population

Evaluation of the Relationship Between Diabetic Macular Edema and Renal Function in a Latino Population

Association between primary angle closure glaucoma and uric acid levels in serum and aqueous humor

Presence and severity of migraine is associated with development of primary open angle glaucoma: A population-based longitudinal cohort study

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