Co-occurrence of celiac disease and other autoimmune diseases in celiacs and their first-degree relatives

Neuhausen, Susan L.; Steele, Linda; Ryan, Sarah; Mousavi, Maryam; Pinto, Marie; Osann, Kathryn; Flodman, Pamela; Zone, John J.

doi:10.1016/j.jaut.2008.06.001

Cited by 114 publications

(105 citation statements)

References 56 publications

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“…The epidemiology of MAS in autoimmune diseases [28,29,30] remains an open question in many cases. To date, the syndrome has been best studied in sJIAs, with estimates of clinically apparent MAS ranging from 7 to 13% [24,31].…”

Section: Case Definition and Epidemiologymentioning

confidence: 99%

Macrophage Activation Syndrome in Autoimmune Disease

Deane

Selmi

Teuber

et al. 2010

Int Arch Allergy Immunol

110

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Macrophage activation syndrome (MAS) is a phenomenon characterized by cytopenia, organ dysfunction, and coagulopathy associated with an inappropriate activation of macrophages. Current diagnostic criteria are imprecise, but the syndrome is now recognized as a form of hemophagocytic lymphohistiocytosis that is characteristically associated with autoimmune diatheses. The diagnosis of incipient MAS in patients with autoimmune disease requires a high index of suspicion, as several characteristics of the disorder may be present in the underlying condition or infectious complications associated with the treatment thereof. Proposed treatment regimens include aggressive approaches that require validation in future controlled studies. This review discusses the major aspects of the pathophysiology, diagnosis, and management of MAS with a focus on the association with autoimmune disease.

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Section: Case Definition and Epidemiologymentioning

confidence: 99%

Macrophage Activation Syndrome in Autoimmune Disease

Deane

Selmi

Teuber

et al. 2010

Int Arch Allergy Immunol

110

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“…More than 60% of CD-associated susceptibility loci are shared with at least another autoimmune condition, suggesting common pathogenic mechanisms [7]. Moreover, an increased prevalence of AIDs has been reported among CD cases and their families as well as an increased prevalence of CD in individuals with other AIDs; supporting the ‘autoimmune tautology' [8,9,10]. …”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Polyautoimmunity among Patients with Celiac Disease: A Cross-Sectional Survey

et al. 2015

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Aim: To define the prevalence of polyautoimmunity (PAI) among celiac disease (CD) patients and to compare clinical and laboratory features of CD patients with or without PAI in order to determine the risk factors for PAI in CD. Material and Method: Patients diagnosed with CD in our clinic between 2007 and 2014 with at least 1 year of follow-up were retrospectively evaluated. Totally 145 patients were included in the study. Information on patient demographics and laboratory data were obtained from patient records. The study participants were divided into 2 groups. Group 1 was the CD-alone group consisting of patients without any other autoimmune diseases (AIDs), while group 2 was the PAI group consisting of patients with accompanying one or more AIDs. Results: The mean age of 145 CD patients (106 female and 39 male) included in the study was 37.2 ± 12.3 years. Of the 145 patients included, 48 (33.1%) were in the PAI group. When two groups were compared with each other in terms of the demographic features and laboratory data, the following were identified as risk factors for PAI: female gender, family history for AIDs, antigliadin IgG positivity, vitamin D deficiency, antinuclear antibody positivity ≥1/80 titer and having any musculoskeletal disease. Conclusion: To the best of our knowledge, this is one of the largest studies in the literature on CD patients for the PAI prevalence and related risk factors. Identification of the risk factors in early stages is important to explore PAI among CD patients. Larger, prospective studies are warranted about the risk factors and autoimmune characteristics of CD.

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“…1 In children ages 2.5 to 15 years this prevalence has been reported as between 0.3% and 1.3%. [2][3][4] Studies have shown an association between CD and numerous autoimmune and rheumatic conditions including rheumatoid arthritis, 5,6 juvenile idiopathic arthritis (JIA), [7][8][9][10] autoimmune thyroiditis, [10][11][12] autoimmune thrombocytopenic purpura, hemolytic anemia, 6 vasculitis, 5,6 polymyositis and dermatomyositis, 13,14 systemic lupus erythematosus (SLE), 5,6,15,16 scleroderma, 5,6 mixed connective tissue disease, 5 diabetes mellitus, [17][18][19][20][21][22] Sjögren syndrome, 6,10,23,24 and dermatitis herpetiformis. 24 Among the connective tissue disorders, only Sjögren syndrome appears to share the HLA DQ2/DQ8 haplotype with CD.…”

Section: What This Study Addsmentioning

confidence: 99%

Unrecognized Celiac Disease in Children Presenting for Rheumatology Evaluation

et al. 2015

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BACKGROUND AND OBJECTIVES: Current clinical guidelines do not consider patients with rheumatic conditions to be at high risk for celiac disease (CD) despite numerous reported associations between the two in adults and children. The objective of this study was to evaluate the prevalence of CD among patients presenting for pediatric rheumatology evaluation.METHODS: A total of 2125 patients presenting for initial evaluation by the Division of Pediatric Rheumatology at the Hospital for Special Surgery between June 2006 and December 2013 were screened for CD as a part of the standard initial serologic evaluation. The charts of these patients were evaluated retrospectively at the end of this period.RESULTS: 36 patients (30 girls, 6 boys, mean age 9.4 6 4.3 years, range 2-16 years) received a diagnosis of CD after serologic testing and evaluation by pediatric gastroenterology. Eight additional patients with known diagnoses of CD presented during this time period. The total prevalence of CD over this 6.5-year period was 2.0%. The most common presenting complaints among patients diagnosed with CD were myalgias, arthralgias, and rash. Less frequently, patients reported gastrointestinal complaints including abdominal pain, nausea, and diarrhea. All patients reported improvement or complete resolution of their musculoskeletal symptoms after initiation of a gluten-free diet.CONCLUSIONS: This study identified 36 new cases of CD among children presenting for rheumatology evaluation, for an overall prevalence rate of 2.0%. The majority of patients who ultimately received a diagnosis of CD presented with extraintestinal manifestations. These results underscore the importance of screening children presenting for rheumatology evaluation for CD. WHAT'S KNOWN ON THIS SUBJECT:Associations have been reported between celiac disease (CD) and numerous autoimmune conditions in adults and children. However, current screening guidelines do not consider patients with rheumatic diseases to be at high risk for CD. WHAT THIS STUDY ADDS:The prevalence of CD in children presenting for rheumatology evaluation was found to be 2% by routine serologic screening. The majority of screening-detected CD cases had no CD-associated symptoms. Gluten restriction was found to relieve some musculoskeletal complaints.

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Co-occurrence of celiac disease and other autoimmune diseases in celiacs and their first-degree relatives

Cited by 114 publications

References 56 publications

Macrophage Activation Syndrome in Autoimmune Disease

Macrophage Activation Syndrome in Autoimmune Disease

Risk Factors for Polyautoimmunity among Patients with Celiac Disease: A Cross-Sectional Survey

Unrecognized Celiac Disease in Children Presenting for Rheumatology Evaluation

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