Co-occurrence of Abuse of Different Drugs in Men

Tsuang, Ming T.; Lyons, Michael J.; Meyer, Joanne M.; Doyle, Thomas J.; Eisen, Seth A.; Goldberg, Jack; True, William R.; Lin, Nong; Toomey, Rosemary; Eaves, Lindon J.

doi:10.1001/archpsyc.55.11.967

Cited by 657 publications

(227 citation statements)

References 35 publications

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“…Nonetheless, our finding is consistent with twin data suggesting that most drug use disorders share a common genetic diathesis (Kendler, et al, 2003, Tsuang, et al, 1998. If that is true, it seems reasonable to posit that members of SUD families share an underlying trait that may be indexed by psychopathological or associated cognitive features.…”

Section: Discussionsupporting

confidence: 89%

“…Family, twin, and adoption studies indicate that genes play a significant etiologic role in the development of substance use disorders (SUDs) (Cloninger, 1987, Luthar and Rounsaville, 1993, Merikangas, et al, 1985, Mirin, et al, 1986, Pickens, et al, 1991, Rounsaville, et al, 1991, Tsuang, et al, 1998. Although these studies have led to the widely accepted conclusion that much of the familial transmission of SUDs is due to genes, the specific genes involved have been difficult to detect.…”

Section: Introductionmentioning

confidence: 99%

“…First, many forms of substance use have been shown through twin and family studies to share genetic risk factors with several forms of psychopathology (Compton, et al, 2005, Kendler, et al, 2003. Second, two twin studies have shown that, although individual SUDs may have some unique sources of genetic etiology, much of the genetic susceptibility to SUDs can be explained by a common genetic diathesis (Kendler, et al, 2003, Tsuang, et al, 1998. Taken together, these findings suggest that the genetic predisposition to SUDs may be indexed by clinical features external to the diagnosis of SUDs, which are typically associated with psychopathology such as symptoms and evidence of adaptive and cognitive impairments.…”

mentioning

confidence: 99%

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Familial transmission of derived phenotypes for molecular genetic studies of substance use disorders

Faraone

Adamson

Wilens

et al. 2008

Drug and Alcohol Dependence

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Although family, twin, and adoption studies indicate that genes play a significant etiologic role in the development of substance use disorders (SUDs), detecting specific genes has been difficult due to uncertainties about how to define SUDs, genetic heterogeneity and variable phenotypic expression of SUD genotypes. We used data from families recruited into six contemporaneous studies of children and adults to derive candidate SUD phenotypes using principle factors factor analysis with varimax rotation. We previously found evidence of two SUD phenotypes in offspring: a psychopathology dimension and a cognitive impairment dimension. We found evidence for one SUD-related phenotype in adults that we term Psychopathology and Cognitive Impairment. Parental factor scores significantly predicted both offspring phenotypes, as well as parental SUD (OR=1.41,p<0.001) and offspring SUD (mother's phenotype: OR=1.34,p=0.04; father's phenotype: OR=1.33,p=0.01). Offspring phenotype predicted offspring SUD (psychopathology phenotype: OR=2.96,p<0.001; cognitive impairment: OR=1.33,p=0.04); in offspring, baseline psychopathology predicted SUD at follow-up assessments (OR=1.55,p=0.01). Results suggest that these candidate SUD phenotypes may be useful for genetic studies of SUD.Correspondence: Dr. Stephen V. Faraone, Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, 750 East Adams St., Syracuse, NY 13210; faraones@upstate.edu, 315-464-3113, (315) 464-3255 (fax). Contributors Stephen V. Faraone participated in study design and execution, planned the analyses, and wrote portions of the manuscript Joel J. Adamson performed data analyses and wrote portions of the manuscript Timothy E. Wilens participated in study design and execution and provided clinical comments on the manuscript Michael C. Monuteaux assisted with the statistical analysis. Participated in study design and execution and provided clinical comments on the manuscript Joseph Biederman participated in study design and execution and provided clinical comments on the manuscript Conflict of Interest Dr. Stephen Faraone receives/d research support from, is/has been a speaker for, or is/has been on the advisory board for the following companies: Eli Lilly & Company, McNeil Consumer & Specialty Pharmaceuticals, Shire US Inc., Noven Pharmaceuticals, Cephalon, National Institute of Mental Health (NIMH), National Institute of Child Health and Human Development (NICHHD), and National Institute of Neurological Disorders and Stroke (NINDS). Dr. Timothy Wilens receives/d research support from, is/has been a speaker for, or is/has been on the advisory board for the following Pharmaceutical Companies: Abbott Laboratories, OrthoMcNeil, Eli Lilly and Company, Novartis Pharmaceuticals, Shire Laboratories Inc. and National Institute on Drug Abuse (NIDA). Dr. Joseph Biederman receives/d research support from, is/has been a speaker for, or is/has been on the advisory board for the following Pharmaceutical Companies: Shire, Eli Lilly, Pfizer, McNeil, Ab...

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Familial transmission of derived phenotypes for molecular genetic studies of substance use disorders

Faraone

Adamson

Wilens

et al. 2008

Drug and Alcohol Dependence

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“…Building on work documenting genetic contributions to antisocial and substance-use behaviors (e.g. Lyons et al 1995 ;Tsuang et al 1998 ;Jacobson et al 2002 ;Kendler et al 2006 ;Torgersen et al 2008), at least three separate research groups have reported evidence for a hierarchal account of the genetics of the externalizing spectrum. In this model, much of the genetic effect on substance dependence (alcohol and illicit substances) and antisocial (conduct disorder and antisocial personality) DSM disorders is in common, yet there are also smaller (but not trivial) residual genetic effects on substance dependence (Young et al 2000 ;Krueger et al 2002 ;Kendler et al 2003).…”

Section: Geneticsmentioning

confidence: 99%

Externalizing disorders: Cluster 5 of the proposed meta-structure for DSM-V and ICD-11

2009

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"Externalizing disorders: Cluster 5 of the proposed meta-structure for DSM-V and ICD-11." Psychological Medicine.39,12. 2061-2070. http://digitalcommons.wustl.edu/open_access_pubs/3931Externalizing disorders: Cluster 5 of the proposed meta-structure for DSM-V and ICD-11Paper 6 of 7 of the thematic section : ' A proposal for a meta-structure for DSM-V and ICD-11 ' R. F. Krueger 1 * and S. C. South 2 1 Departments of Psychology and Psychiatry, Washington University in St Louis, St Louis, MO, USA 2 Department of Psychology, Purdue University, Lafayette, IN, USA Background. The extant major psychiatric classifications DSM-IV and ICD-10 are purportedly atheoretical and largely descriptive. Although this achieves good reliability, the validity of a medical diagnosis is greatly enhanced by an understanding of the etiology. In an attempt to group mental disorders on the basis of etiology, five clusters have been proposed. We consider the validity of the fifth cluster, externalizing disorders, within this proposal.Method. We reviewed the literature in relation to 11 validating criteria proposed by the Study Group of the DSM-V Task Force, in terms of the extent to which these criteria support the idea of a coherent externalizing spectrum of disorders.Results. This cluster distinguishes itself by the central role of disinhibitory personality in mental disorders spread throughout sections of the current classifications, including substance dependence, antisocial personality disorder and conduct disorder. Shared biomarkers, co-morbidity and course offer additional evidence for a valid cluster of externalizing disorders.Conclusion. Externalizing disorders meet many of the salient criteria proposed by the Study Group of the DSM-V Task Force to suggest a classification cluster.

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“…In comparison to most addictive substances, the vulnerability of heroin abuse appears to have a significant genetic load (6). Several genetic variations of the human MOR gene (OPRM1) have been identified.…”

mentioning

confidence: 99%

μ Opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers

Drakenberg¹,

Nikoshkov²,

Horváth

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

104

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Opioid receptors are critical for heroin dependence, and A118G SNP of the opioid receptor gene (OPRM1) has been linked with heroin abuse. In our population of European Caucasians (n ‫؍‬ 118), Ϸ90% of 118G allelic carriers were heroin users. Postmortem brain analyses showed the OPRM1 genotype associated with transcription, translation, and processing of the human striatal opioid neuropeptide system. Whereas down-regulation of preproenkephalin and preprodynorphin genes was evident in all heroin users, the effects were exaggerated in 118G subjects and were most prominent for preproenkephalin in the nucleus accumbens shell. Reduced opioid neuropeptide transcription was accompanied by increased dynorphin and enkephalin peptide concentrations exclusively in 118G heroin subjects, suggesting that the peptide processing is associated with the OPRM1 genotype. Abnormal gene expression related to peptide convertase and ubiquitin͞proteosome regulation was also evident in heroin users. Taken together, alterations in opioid neuropeptide systems might underlie enhanced opiate abuse vulnerability apparent in 118G individuals.drug abuse ͉ dynorphin ͉ enkephalin ͉ mRNA

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Co-occurrence of Abuse of Different Drugs in Men

Abstract: Background: Previous research has demonstrated genetic and environmental influences on abuse of individual substances, but there is less known about how these factors may influence the co-occurrence of abuse of different illicit drugs.

Cited by 657 publications

References 35 publications

Familial transmission of derived phenotypes for molecular genetic studies of substance use disorders

Familial transmission of derived phenotypes for molecular genetic studies of substance use disorders

Externalizing disorders: Cluster 5 of the proposed meta-structure for DSM-V and ICD-11

μ Opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers

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