Co-morbidity and pain sites in long-term gynecological cancer survivors and women in the general population

Rannestad, Toril; Skjeldestad, Finn Egil

doi:10.1016/j.ygyno.2012.06.016

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…Although uncommon, important sequelae of radiation to bone, such as pathologic fractures, osteoradionecrosis, and second malignancies, are associated with a decrease in quality of life and increase in mortality . The factors that influence bone toxicity include radiation dose (>50 Gy) as well as patient factors, such as age, menopausal status, presence of underlying bone weakness (such as osteopenia or osteoporosis), corticosteroid use, cigarette smoking, and vascular integrity.…”

Section: Introductionmentioning

confidence: 99%

Complications of pelvic radiation in patients treated for gynecologic malignancies

Viswanathan

Lee

Eswara

et al. 2014

Cancer

140

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Radiation therapy is a critical treatment modality in the management of patients with gynecologic tumors. New highly conformal external‐beam and brachytherapy techniques have led to important reductions in recurrence and patient morbidity and mortality. However, patients who receive pelvic radiation for gynecologic malignancies may experience a unique constellation of toxicity because of the anatomic locations, combination with concurrent chemotherapy and/or surgery, as well as potential surgical interventions. Although side effects are often categorized into acute versus late toxicities, several late toxicities represent continuation and evolution of the same pathologic process. Comorbidities and radiation dose can significantly increase the risk of morbidity. Current understanding of the incidence of various morbidities in patients treated with current radiation techniques for gynecologic malignancies, the impact of chemotherapy and surgery, treatment options for those effects, and future areas of research are highlighted. Cancer 2014;120:3870–3883. © 2014 American Cancer Society.

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Section: Introductionmentioning

confidence: 99%

Complications of pelvic radiation in patients treated for gynecologic malignancies

Viswanathan

Lee

Eswara

et al. 2014

Cancer

140

View full text Add to dashboard Cite

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“…Subsequently, thirteen articles were excluded after further evaluation of the full text and for following reasons. Four articles 14 15 16 17 were replaced by updated or more informative studies, and eight articles 18 19 20 21 22 23 24 25 did not present usable results, while one article 26 reported the crude risk estimate without adjustment for any potential confounders or established prognostic factors. In the end, a total of 8 articles 6 7 8 9 10 11 12 13 met our inclusion criteria for the final meta-analysis ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Comorbidity and survival among women with ovarian cancer: evidence from prospective studies

Jiao

Gong

Wang

et al. 2015

Sci Rep

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The relationship between comorbidity and ovarian cancer survival has been controversial so far. Therefore, we conducted a meta-analysis to summarize the existing evidence from prospective studies on this issue. Relevant studies were identified by searching the PubMed, EMBASE, and ISI Web of Science databases through the end of January 2015. Two authors independently performed the eligibility evaluation and data abstraction. Random-effects models were used to estimate summary hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival. Eight prospective studies involving 12,681 ovarian cancer cases were included in the present study. The summarized HR for presence versus absence of comorbidity was 1.20 (95% CI = 1.11–1.30, n = 8), with moderate heterogeneity (I2 = 31.2%, P = 0.179). In addition, the summarized HR for the highest compared with the lowest category of the Charlson’s comorbidity index was 1.68 (95% CI = 1.50–1.87, n = 2), without heterogeneity (I2 = 0%, P = 0.476). Notably, a significant negative impact of comorbidity on ovarian cancer survival was observed in most subgroup analyses stratified by the study characteristics and whether there was adjustment for potential confounders. In conclusion, the findings of this meta-analysis suggest that underlying comorbidity is consistently associated with decreased survival in patients with ovarian cancer. Comorbidity should be taken into account when managing these patients.

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Lived experiences and quality of life after gynaecological cancer—An integrative review

Sekse

Dunberger²,

Olesen

et al. 2019

Journal of Clinical Nursing

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Aim and objectives To review the literature on Nordic women's lived experiences and quality of life (QoL) after gynaecological cancer treatment. Background While incidence and survival are increasing in all groups of gynaecological cancers in the Nordic countries, inpatient hospitalisation has become shorter in relation to treatment. This has increased the need for follow‐up and rehabilitation. Design Integrative literature review using the Equator PRISMA guidelines. Methods The review was selected, allowing inclusion of both experimental and nonexperimental research. The search included peer‐reviewed articles published 1995–2017. To frame the search strategy, we applied the concept of rehabilitation, which holds a holistic perspective on health. Results Fifty‐five articles were included and were contextualised within three themes. Physical well-being in a changed body encompasses bodily changes comprising menopausal symptoms, a changed sexual life, complications in bowels, urinary tract, lymphoedema and pain, bodily‐based preparedness and fear of recurrence. Mental well-being as a woman deals with questioned womanliness, the experience of revitalised values in life, and challenges of how to come to terms with oneself after cancer treatment. Psychosocial well-being and interaction deals with the importance of having a partner or close person in the process of coming to terms with oneself after cancer. Furthermore, the women needed conversations with health professionals around the process of coping with changes and late effects, including intimate and sensitive issues. Conclusion Years after gynaecological cancer, women have to deal with fundamental changes and challenges concerning their physical, mental and psychosocial well‐being. Future research should focus on how follow‐up programmes can be organised to target the multidimensional aspects of women's QoL. Research collaboration across Nordic countries on rehabilitation needs and intervention is timely and welcomed. Relevance to clinical practice To ensure that all aspects of cancer rehabilitation are being addressed, we suggest that the individual woman is offered an active role in her follow‐up.

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Co-morbidity and pain sites in long-term gynecological cancer survivors and women in the general population

Cited by 3 publications

References 32 publications

Complications of pelvic radiation in patients treated for gynecologic malignancies

Complications of pelvic radiation in patients treated for gynecologic malignancies

Comorbidity and survival among women with ovarian cancer: evidence from prospective studies

Lived experiences and quality of life after gynaecological cancer—An integrative review

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