Co-morbidities in patients with gold stage 4 chronic obstructive pulmonary disease

Areias, Vanda; Carreira, S.; Anciães, Marisa; Pinto, Paula; Bárbara, Cristina

doi:10.1016/j.rppnen.2013.09.001

Cited by 19 publications

(20 citation statements)

References 23 publications

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“…In a study by Areias et al , 89 patients with COPD were included based on a questionnaire designed to characterise COPD and its comorbidities. GERD was detected in 29% of the patients with COPD and 39% were ‘frequent exacerbators.’ More importantly, ‘frequent exacerbators’ had a significantly higher prevalence of GERD ( P = .0006) and more hospitalisations in the last year and in the previous 5 years ( P < .001) …”

Section: Methodsmentioning

confidence: 99%

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Review article: gastro‐oesophageal reflux disease in asthma and chronic obstructive pulmonary disease

Broers

Tack

Pauwels

2017

Aliment Pharmacol Ther

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Section: Methodsmentioning

confidence: 99%

“…COPD is associated with several comorbidities, for example, cardiovascular diseases, sleep apnoea syndrome, dyslipidaemia, diabetes and also GERD . The association between GERD and COPD has been under investigation for many years; however, the impact of GERD on COPD‐related health status remains questionable …”

Section: Methodsmentioning

confidence: 99%

Review article: gastro‐oesophageal reflux disease in asthma and chronic obstructive pulmonary disease

Broers

Tack

Pauwels

2017

Aliment Pharmacol Ther

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“…The prevalence of chronic obstructive pulmonary disease (COPD) has increased dramatically in Western populations during the last few decades [1,2], and has become a major challenge to public health and healthcare systems due to frequent hospitalisations, severe comorbidities and a high mortality rate [2,3]. Venous thromboembolism (VTE), a collective term for deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common disease with complications such as the post-thrombotic syndrome, chronic thromboembolic pulmonary hypertension and death [4,5].…”

Section: Introductionmentioning

confidence: 99%

COPD and risk of venous thromboembolism and mortality in a general population

et al. 2015

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The relationship between chronic obstructive pulmonary disease (COPD) and risk of venous thromboembolism (VTE) has been scarcely studied in the general population. We aimed to investigate the association between COPD and risk of VTE and mortality in a population-based cohort.Spirometry was conducted in 8646 males and females, participating in the fifth (2001-02) and sixth (2007-08) surveys of the Tromsø Study. Incident VTE events during follow-up were registered from the date of inclusion to December 31, 2011. Cox-regression models with COPD stages and confounders as time varying covariates were used to calculate hazard ratios with 95% confidence intervals for VTE and all-cause mortality.During a median follow-up of 6.2 years, 215 subjects developed VTE. Subjects with COPD stage III/IV had a two-fold higher risk of secondary VTE compared to subjects with normal airflow (HR 2.05, 95% CI 1.02-4.10). COPD patients, particularly those with stage III/IV disease, with VTE had a higher mortality rate than COPD patients without VTE (50.2% versus 5.6% per year).Our findings suggest that patients with severe COPD may have increased risk of secondary VTE, and that COPD patients with VTE have a higher mortality rate than COPD patients without VTE. @ERSpublications Patients with severe COPD may have increased risk of VTE: VTE is associated with a worse prognosis in COPD patients

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“…COPD is expected to become the third leading cause of death globally by 2030 . It has grown into a major challenge for public health and health‐care systems due to the associated frequent hospitalizations, severe comorbidities and high mortality rates …”

Section: Introductionmentioning

confidence: 99%

“…3 It has grown into a major challenge for public health and health-care systems due to the associated frequent hospitalizations, severe comorbidities and high mortality rates. 4,5 Venous thromboembolism (VTE) includes deep venous thrombosis (DVT) and pulmonary embolism (PE). COPD is considered to be a moderate risk factor for VTE.…”

Section: Introductionmentioning

confidence: 99%

Association between features of COPD and risk of venous thromboembolism

Dong

Zhu

et al. 2019

Clinical Respiratory J

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Introduction Chronic obstructive pulmonary disease (COPD) is associated with risk of venous thromboembolism (VTE) events. A detailed understanding of which clinical features of COPD increase risk of VTE events is needed. Objectives To investigate the association between features of COPD and risk of venous thromboembolism. Methods A retrospective observational clinical study was conducted on 551 consecutive COPD patients visiting the Department of Respiratory and Critical Care Medicine of Tianjin Chest Hospital between February 2014 and April 2018. Finally, 151 patients were eligible for inclusion. Of these, 29 patients had COPD with VTE and 121 patients had COPD without VTE. Patient informations regarding age, gender, BMI, smoking history, smoking status (package/year), COPD‐related symptoms, lung function, number of acute exacerbations and imaging visual emphysema were gathered. Results Among the 29 VTE patients, 18 patients had PE and five had DVT, while 6 patients had simultaneous PE and DVT. There were statistically significant differences in GOLD grade, Imaging visual emphysema, and frequent acute exacerbations between the two groups. Multivariate logistic regression analysis showed that after adjustment for gender, age, BMI and smoking history, there were statistically significant for visible emphysema (OR = 3.54, 95% CI: 1.13‐11.08; P = 0.03) and GOLD grade (OR = 1.77, 95% CI: 1.04‐3.01; P = 0.035), but not for frequent acute exacerbations (OR = 1.65, 95% CI: 0.62‐4.38; P = 0.31). Conclusions Visual emphysema is an independent risk factor for VTE events and the risk of VTE in COPD patients increases with the degree of airway obstruction. However, there is no evidence of an association between exacerbation frequency and VTE events.

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Co-morbidities in patients with gold stage 4 chronic obstructive pulmonary disease

Cited by 19 publications

References 23 publications

Review article: gastro‐oesophageal reflux disease in asthma and chronic obstructive pulmonary disease

Review article: gastro‐oesophageal reflux disease in asthma and chronic obstructive pulmonary disease

COPD and risk of venous thromboembolism and mortality in a general population

Association between features of COPD and risk of venous thromboembolism

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