Co-introgression of Y-chromosome haplogroups and the sickle cell gene across Africa's Sahel

Bereir, R E H; Hassan, Hisham Y.; Salih, Niven A; Underhill, Peter A.; Cavalli-Sforza, Luigi Luca; Hussain, Ayman; Kwiatkowski, Dominic P.; Ibrahim, Muntaser E.

doi:10.1038/sj.ejhg.5201892

Cited by 18 publications

(19 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ethnic groups and populations inhabiting West Kordofan State were representative of geographic regions from Africa's Sahel into Chad and West Sudan and encompass the main linguistic families of Africa (Afro‐Asiatic, Niger Kordofanian and Nilo‐Saharan) . The towns selected for the study are the major settlements sites for the nomadic Bagara, settlers and immigrants tribes from Darfur and West‐Central Africa.…”

Section: Methodsmentioning

confidence: 99%

Sickle cell disease in western Sudan: genetic epidemiology and predictors of knowledge attitude and practices

Daak

El-Samani

Ali

et al. 2016

Tropical Med Int Health

View full text Add to dashboard Cite

Summaryobjective To investigate the epidemiology of sickle cell disease (SCD) and determinants of knowledge, attitudes and practices (KAP) towards SCD in western Kordofan State, Sudan.methods A community-based, descriptive, cross-sectional study was conducted in three towns. Three hundred and seventy-two households were polled, and blood samples for haemoglobin phenotyping were collected from 1116 individuals. Sociodemographic, socio-economic and KAP data were collected using investigator-administered questionnaires. Descriptive, frequency distribution and multiple regression analyses were performed.results About 50.9% of the study population were Misseriya tribes. Consanguineous marriages were reported by 67.5% of the households. The highest percentage of homozygous SCD was 2.8% among children under 5 years of age. About 24.9% were carriers of HbS allele (HbAS). HbS allele frequency was highest in children aged 5-11 years (18.3%, CI: 13.7-22.9%) and lowest in males >15 years old (12.0%, CI: 6.1-17.9%). The average HbS frequency across all age groups was 14.5% (95% CI: 12.2-16.8%). The most frequent b-globin gene cluster haplotype was the Cameroon (30.8%), followed by the Benin (21.8%), the Senegal (12.8%) and the Bantu (2.2%) haplotypes. About 17.0% of all-cause child deaths were due to SCD. The estimated change in log odds of having the SS genotype per year increase in age was (À) 0.0058 (95% CI À0.0359, 0.0242). This represents a non-statistically significant 2.9% increase in 5-year mortality for individuals with the SS genotype relative to those with AS and AA genotypes. About 46.9% of the households had poor knowledge, 26.1% had satisfactory knowledge, and 26.9% had good knowledge about sickle cell disease. Mothers' and fathers' educational levels were significant predictors of good knowledge about SCD (P < 0.05). About 48.0% had a satisfactory attitude towards sickle cell disease while 30.7% had poor attitude and only 21.3 showed good attitudes. Poor knowledge about SCD and low socioeconomic status were the strongest positive predictors of poor attitude and practices towards SCD (P < 0.01).conclusions Sickle cell disease is a major health problem in West Kordofan, Sudan. Knowledge, attitude and practices towards the disease are not satisfactory. The development of public health programs is highly recommended to control and manage SCD in western parts of Sudan.keywords sickle cell disease, genetic epidemiology, western Sudan, haplotypes, knowledge attitude and practices 642

show abstract

Section: Methodsmentioning

confidence: 99%

Sickle cell disease in western Sudan: genetic epidemiology and predictors of knowledge attitude and practices

Daak

El-Samani

Ali

et al. 2016

Tropical Med Int Health

View full text Add to dashboard Cite

show abstract

“…There is increasing archaeological, linguistic, and genetic evidence that the Sahel has been an important region for bidirectional migration between western and eastern Africa (1,(40)(41)(42). Linguistic evidence indicates population interactions for ∼20-10 kya between the Nilo-Saharan and Afroasiatic speakers in this region (43).…”

Section: Neolithic In Africamentioning

confidence: 99%

Working toward a synthesis of archaeological, linguistic, and genetic data for inferring African population history

Scheinfeldt¹,

Soi

Tishkoff

2010

Proc. Natl. Acad. Sci. U.S.A.

101

View full text Add to dashboard Cite

Although Africa is the origin of modern humans, the pattern and distribution of genetic variation and correlations with cultural and linguistic diversity in Africa have been understudied. Recent advances in genomic technology, however, have led to genomewide studies of African samples. In this article, we discuss genetic variation in African populations contextualized with what is known about archaeological and linguistic variation. What emerges from this review is the importance of using independent lines of evidence in the interpretation of genetic and genomic data in the reconstruction of past population histories.

show abstract

“…2,4 Using the conventional Y-chromosome haplogroup nomenclature, the majority of lineages observed in contemporary European populations fall into the following main haplogroups: E, G, I, J, N and R. Typically, 450% of men in Europe are affiliated with haplogroup R. 5,6 Members of haplogroup R are also widespread in Western, 7,8 Central 9 and Southern Asia 10,11 as well as in some parts of the Sahel region of Africa. 12,13 In Europe, essentially all R associates belong to its sub-clade R1 defined by M173. Two R1 subclades show distinctive geographic distributions where Germany represents a major differentiation zone.…”

Section: Introductionmentioning

confidence: 99%

A major Y-chromosome haplogroup R1b Holocene era founder effect in Central and Western Europe

Myres¹,

et al. 2010

Self Cite

View full text Add to dashboard Cite

The phylogenetic relationships of numerous branches within the core Y-chromosome haplogroup R-M207 support a West Asian origin of haplogroup R1b, its initial differentiation there followed by a rapid spread of one of its sub-clades carrying the M269 mutation to Europe. Here, we present phylogeographically resolved data for 2043 M269-derived Y-chromosomes from 118 West Asian and European populations assessed for the M412 SNP that largely separates the majority of Central and West European R1b lineages from those observed in Eastern Europe, the Circum-Uralic region, the Near East, the Caucasus and Pakistan. Within the M412 dichotomy, the major S116 sub-clade shows a frequency peak in the upper Danube basin and Paris area with declining frequency toward Italy, Iberia, Southern France and British Isles. Although this frequency pattern closely approximates the spread of the Linearbandkeramik (LBK), Neolithic culture, an advent leading to a number of pre-historic cultural developments during the past r10 thousand years, more complex pre-Neolithic scenarios remain possible for the L23(xM412) components in Southeast Europe and elsewhere.

show abstract

Co-introgression of Y-chromosome haplogroups and the sickle cell gene across Africa's Sahel

Cited by 18 publications

References 9 publications

Sickle cell disease in western Sudan: genetic epidemiology and predictors of knowledge attitude and practices

Sickle cell disease in western Sudan: genetic epidemiology and predictors of knowledge attitude and practices

Working toward a synthesis of archaeological, linguistic, and genetic data for inferring African population history

A major Y-chromosome haplogroup R1b Holocene era founder effect in Central and Western Europe

Contact Info

Product

Resources

About