Co-infection with Zika and Chikungunya viruses associated with fetal death—A case report

Prata‐Barbosa, Arnaldo; Cleto-Yamane, Thaís Lira; Robaina, Jaqueline Rodrigues; Guastavino, Andréa B; Magalhães‐Barbosa, Maria Clara de; Brindeiro, Rodrigo de Moraes; Medronho, Roberto de Andrade; Cunha, Antônio José Lêdo Alves da

doi:10.1016/j.ijid.2018.04.4320

Cited by 23 publications

(17 citation statements)

References 16 publications

(18 reference statements)

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“…CHIKV has been detected in the placenta and amniotic fluid of infected mothers, which supports this platform as an in vitro mechanism for studying the kinetics of congenital CHIKV infections [5,6,42,43]. The virus was quantified via titration in Vero cells and by RT-PCR.…”

Section: Discussionmentioning

confidence: 55%

Antibodies for Venezuelan Equine Encephalitis Virus Protect Embryoid Bodies from Chikungunya Virus

Schultz

Jones

Barr

2020

Viruses

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Chikungunya virus (CHIKV) is an alphavirus that causes febrile illness punctuated by severe polyarthralgia. After the emergence of CHIKV in the Western Hemisphere, multiple reports of congenital infections were published that documented neurological complications, cardiac defects, respiratory distress, and miscarriage. The Western Hemisphere is endemic to several alphaviruses, and whether antigenic cross-reactivity can impact the course of infection has not been explored. Recent advances in biomedical engineering have produced cell co-culture models that replicate the cellular interface at the maternal fetal axis. We employed a trans-well assay to determine if cross-reactive antibodies affected the movement and replication of CHIKV across placental cells and into an embryoid body. The data showed that antibodies to Venezuelan equine encephalitis virus significantly reduced CHIKV viral load in embryoid bodies. The data highlighted the fact that viral pathogenesis can be cell-specific and that exploiting antigenic cross-reactivity could be an avenue for reducing the impact of congenital CHIKV infections.

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Section: Discussionmentioning

confidence: 55%

Antibodies for Venezuelan Equine Encephalitis Virus Protect Embryoid Bodies from Chikungunya Virus

Schultz

Jones

Barr

2020

Viruses

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show abstract

“…CHIKV has been detected in the placenta and amniotic fluid of infected mothers which supports this platform as an in vitro mechanism for studying the kinetics of congenital CHIKV infections [5,6,28,29]. Virus was quantified via titration in Vero cells and by RT-PCR.…”

Section: Discussionmentioning

confidence: 88%

Antibodies for Venezuelan Equine Encephalitis Virus Protect Embryoid Bodies from Chikungunya Virus

Schultz¹,

Jones²,

Clamp³

et al. 2019

Preprint

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Chikungunya virus (CHIKV) is an alphavirus that causes febrile illness punctuated by severe polyarthralgia. After the emergence of CHIKV in the Western Hemisphere, multiple reports of congenital infections were published that documented neurological complications, cardiac defects, respiratory distress, and miscarriage. The Western Hemisphere is endemic to several alphaviruses and whether antigenic cross-reactivity can impact the course of infection has not been explored. Recent advances in biomedical engineering have produced cell co-culture models that replicate the cellular interface at the maternal fetal axis. We employed a trans-well assay to determine if cross-reactive antibodies affected the movement and replication of CHIKV across placental cells and into an embryoid body. The data show that antibodies to Venezuelan equine encephalitis virus (VEEV) significantly reduced CHIKV viral load in embryoid bodies. The data highlight that viral pathogenesis can be cell-specific and that exploiting antigenic cross-reactivity could be an avenue for reducing the impact of congenital CHIKV infections.

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“…Foetal mortality cases were associated with ZIKV–CHIKV coinfection. Similarly, a case of foetal death associated with coinfection by ZIKV–CHIKV in a Brazilian pregnant woman has been reported [ 26 ]. The foetus had no apparent anomalies.…”

Section: Discussionmentioning

confidence: 99%

Dengue, chikungunya and zika virus coinfection: results of the national surveillance during the zika epidemic in Colombia

Mercado-Reyes¹,

Acosta‐Reyes

Navarro

et al. 2019

Epidemiol. Infect.

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Our objective was to determine the frequency of zika (ZIKV), chikungunya (CHIKV) and dengue (DENV) virus coinfection and describe the mortality cases that occurred during the epidemiologic surveillance of the ZIKV epidemic in Colombia. We analysed all cases of suspected ZIKV infection that were reported to the National Institute of Health (October 2015–December 2016). DENV, CHIKV and ZIKV RNA were detected in serum or tissue samples using polymerase chain reaction assay. Medical records of the fatal cases were reviewed. We identified that 23 871 samples were processed. The frequency of viral agents was 439 (1.84%) for DENV, 257 (1.07%) for CHIKV and 10118 (42.38%) for ZIKV. Thirty-four (0.14%) cases of coinfection were identified. The CHIKV–ZIKV coinfection was present in 28 cases (82.3%), DENV–CHIKV in three (8.8%) and DENV–ZIKV in three (8.8%). Seven (20.6%) coinfection cases were fatal (two DENV–CHIKV cases and five CHIKV–ZIKV cases). Two cases were foetal deaths and the others were related to neurological syndrome and sepsis. In conclusion, the frequency of arbovirus coinfection during epidemic of ZIKV was low, and CHIKV–ZIKV coinfection was the most common. Mortality was high among coinfection patients. The role of each virus in the mortality cases of coinfection warrants further studies.

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Co-infection with Zika and Chikungunya viruses associated with fetal death—A case report

Cited by 23 publications

References 16 publications

Antibodies for Venezuelan Equine Encephalitis Virus Protect Embryoid Bodies from Chikungunya Virus

Antibodies for Venezuelan Equine Encephalitis Virus Protect Embryoid Bodies from Chikungunya Virus

Antibodies for Venezuelan Equine Encephalitis Virus Protect Embryoid Bodies from Chikungunya Virus

Dengue, chikungunya and zika virus coinfection: results of the national surveillance during the zika epidemic in Colombia

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