2020
DOI: 10.1186/s12879-020-05349-0
|View full text |Cite
|
Sign up to set email alerts
|

Co-infection with trichomonas vaginalis increases the risk of cervical intraepithelial neoplasia grade 2–3 among HPV16 positive female: a large population-based study

Abstract: Background: Evidence suggested that vaginal microbiome played a functional role in the progression of cervical lesions in female infected by HPV. This study aimed at evaluating the influence of common vaginal infection on the carcinogenicity of high risk HPV (hr-HPV). Methods: From January 15, 2017 to December 31, 2017, 310,545 female aged at least 30 years old had been recruited for cervical cancer screening from 9 clinical research centers in Central China. All the recruited participants received hr-HPV geno… Show more

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
19
0
3

Year Published

2021
2021
2024
2024

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 25 publications
(23 citation statements)
references
References 46 publications
(74 reference statements)
1
19
0
3
Order By: Relevance
“…Intimate infections also increase probability of cervical cancer occurrence in patient -attention is paid, among others, to vaginal trichomoniasis, which, with HPV co-infection, significantly increased the risk of this cancer development [9]. Over 80% of women taking part in the own study knew the risk concerning intimate infections (Figure 2), which is a satisfactory result.…”
Section: Resultsmentioning
confidence: 90%
See 2 more Smart Citations
“…Intimate infections also increase probability of cervical cancer occurrence in patient -attention is paid, among others, to vaginal trichomoniasis, which, with HPV co-infection, significantly increased the risk of this cancer development [9]. Over 80% of women taking part in the own study knew the risk concerning intimate infections (Figure 2), which is a satisfactory result.…”
Section: Resultsmentioning
confidence: 90%
“…Cervical cancer risk factors include age, early onset of sexual intercourse, big number of sexual partners, [12], highly processed food and vitamins deficiencies [6], smoking cigarettes [7], oral hormonal contraception [8], intimate infections [9], disorders of the vaginal flora [10], number of births [11] and persistent human papillomavirus infection [12].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…T. vaginalis infection has been considered as a risk factor for cervical cancer ( Tao et al, 2014 ) as well as with aggressive prostate cancer ( Sutcliffe et al, 2006 ) and prostate hyperplasia ( Mitteregger et al, 2012 ). In addition, Trichomonas infection has been correlated with an increased risk of high-grade cervical cancer in patients with HPV16, suggesting that the protist may affect carcinogenicity of viruses ( Yang et al, 2020 ).…”
Section: Trichomonas Vaginalis and Mycoplasma Homimentioning
confidence: 99%
“…TV accounts for close to half of the annual incidence of nearly half-a-billion sexually transmitted infections (STIs) according to WHO estimates (WHO, 2012;Rowley et al, 2019). Adding to the public health care burden, TV is associated with adverse pregnancy outcomes, high-risk HPV genotypes and cancer (Fichorova, 2009;Yang et al, 2020), as well as with HIV acquisition (Cu-Uvin et al, 1999;Van Der Pol et al, 2008) and transmission (Kissinger et al, 2009). Bacterial vaginosis (BV), a common syndrome of disturbed vaginal microbiota, goes handin-hand with TV infection (Onderdonk et al, 2016) and is also associated with HIV acquisition (Atashili et al, 2008), shedding and transmission (Low et al, 2014) and with HPV infection (Oh et al, 2015;Yang et al, 2018;Liang et al, 2019;Brusselaers et al, 2019;Norenhag et al, 2019) and lower rates of HPV clearance (King et al, 2011).…”
Section: Introductionmentioning
confidence: 99%