Co-infection With Hepatitis B in Tuberculosis Patients on Anti-tuberculosis Treatment and the Final Outcome

Khan, Amir Farooq; Sajjad, Ahsan; Mian, Dedaar A; Tariq, Muhammad Mansoor; Jadoon, Usman K; Abbas, Muhammad; Shakeel, Kinza; Saeed, Nadia; Abbas, Kiran

doi:10.7759/cureus.14433

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…However, one study found that patients who received antiviral drugs shortly after being diagnosed with TB had a lower risk of liver damage caused by anti-TB drug hepatotoxicity (3). Based on the risks listed above, a series of worldwide studies set out similar tasks as in the present study to establish the prevalence rates of viral hepatitis in TB patients in order to assess their potential risk (1,2,11,(16)(17)(18)(19).…”

Section: Discussionmentioning

confidence: 95%

Seroprevalence of viral hepatitis B, C and E in TB patients from the Republic of Moldova

SAJIN,

SPINU,

ISAC

et al. 2023

OH&RM

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Introduction. For the first time, in the Republic of Moldova, there was established the seroprevalence of viral hepatitis B, C and E markers in patients with tuberculosis depending on gender, age and geographical areas. Material and methods. 200 blood samples were collected from patients with tuberculosis and tested by the immuno-fermentative method for presence of viral hepatitis B, C and E markers. Results. Following the investigations, it was established that the seroprevalence of the anti-HEV Ig marker in patients with tuberculosis is 12.0±2.3%. The seroprevalence of viral hepatitis B marker HBsAg in patients with tuberculosis was 13.5±2.4%, and that of viral hepatitis C anti-HCV – 9.0±2.0%. The study of investigations results for the presence of nominated markers depending on the geographical areas showed a significant statistically difference in the seroprevalence of the anti-HEV IgG marker in TB patients in the Central area of the country compared to the Southern area(p<0.05). Conclusions. Patients with tuberculosis have a higher risk of developing viral hepatitis B, C and E, mainly affecting people aged 40-49 and > 60 years, including males.

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Section: Discussionmentioning

confidence: 95%

Seroprevalence of viral hepatitis B, C and E in TB patients from the Republic of Moldova

SAJIN,

SPINU,

ISAC

et al. 2023

OH&RM

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“…Un reciente metaanálisis que incluyó más de 15.000 pacientes ha mostrado que la coexistencia de VHC en pacientes con TB alcanza el 7% 18 . Los pacientes coinfectados resultan de particular importancia, dado que algunos reportes de casos han mostrado que la aparición concomitante de estas dos patologías se asocia con una mala respuesta al tratamiento [19][20] . Más aún, un estudio de casos y controles demostró que los pacientes diagnosticados con tuberculosis e infección concomitante por el virus de la hepatitis B mostraron peor respuesta al tratamiento en comparación con pacientes con TB sin HVC (<0.001).…”

Section: Discussionunclassified

Importancia del abordaje terapéutico y detección precoz de la coinfección por tuberculosis y hepatitis

Rodríguez¹

2022

RFEM

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Importancia del abordaje terapéutico y detección precoz de la coinfección por tuberculosis y hepatitisImportance of the therapeutic approach and early detection of tuberculosis and hepatitis coinfectionMario Schiter Rodríguez RESUMENLa coinfección de tuberculosis (TB) y hepatitis B (VHB) o hepatitis C (VHC) constituye un desafío para el sistema sanitario. La evidencia indica que los pacientes coinfectados presentan una mala respuesta al tratamiento por la VHC y cuadros de TB más severos, con mayor número de recurrencias de la enfermedad. El objetivo de este trabajo fue describir el caso de una paciente con VHC que concurrió a la guardia por tos y hemoptisis, y realizar una actualización bibliográfica. Se presentó paciente mujer, joven, que concurrió a la guardia por hemoptisis y tos de varios meses de evolución. La mujer había comenzado recientemente el tratamiento por VHC, realizó un esputo el cual resultó positivo para Mycobacterium tuberculosis. Se inició el tratamiento y dieron pautas de cuidado. La TB y la infección por VHC son dos importantes problemas de salud pública. La coinfección de TB y hepatitis vírica aumenta el riesgo de hepatotoxicidad inducida por el tratamiento antituberculoso de primera línea; sin embargo, no existe un consenso sobre estrategias terapéuticas, lo que sugiere implementar un abordaje multidisciplinario para lograr resultados clínicamente exitosos minimizando eventos adversos.

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“…In-hospital comorbidity data were obtained from the chief complaints of patients, which is consistent with the review results after admission to the hospital. For reflecting the nutritional status of research objects, this study converted the height and weight into the body mass index (BMI) according to Medical Nutrition Treatment of Overweight/Obesity in China (2021), where BMI values less than 18.5 kg/m² are considered underweight, BMI values from 18.5 to 24.99 kg/m² are normal weight. BMI values > 25 kg/m² were overweight or obese (Chen et al, 2004;Sahile et al, 2021).…”

Section: Data Collectionmentioning

confidence: 99%

A nomogram for predicting mortality of patients initially diagnosed with primary pulmonary tuberculosis in Hunan province, China: a retrospective study

Tang

Lei

et al. 2023

Front. Cell. Infect. Microbiol.

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ObjectiveAccording to the Global Tuberculosis Report for three consecutive years, tuberculosis (TB) is the second leading infectious killer. Primary pulmonary tuberculosis (PTB) leads to the highest mortality among TB diseases. Regretfully, no previous studies targeted the PTB of a specific type or in a specific course, so models established in previous studies cannot be accurately feasible for clinical treatments. This study aimed to construct a nomogram prognostic model to quickly recognize death-related risk factors in patients initially diagnosed with PTB to intervene and treat high-risk patients as early as possible in the clinic to reduce mortality.MethodsWe retrospectively analyzed the clinical data of 1,809 in-hospital patients initially diagnosed with primary PTB at Hunan Chest Hospital from January 1, 2019, to December 31, 2019. Binary logistic regression analysis was used to identify the risk factors. A nomogram prognostic model for mortality prediction was constructed using R software and was validated using a validation set.ResultsUnivariate and multivariate logistic regression analyses revealed that drinking, hepatitis B virus (HBV), body mass index (BMI), age, albumin (ALB), and hemoglobin (Hb) were six independent predictors of death in in-hospital patients initially diagnosed with primary PTB. Based on these predictors, a nomogram prognostic model was established with high prediction accuracy, of which the area under the curve (AUC) was 0.881 (95% confidence interval [Cl]: 0.777-0.847), the sensitivity was 84.7%, and the specificity was 77.7%.Internal and external validations confirmed that the constructed model fit the real situation well.ConclusionThe constructed nomogram prognostic model can recognize risk factors and accurately predict the mortality of patients initially diagnosed with primary PTB. This is expected to guide early clinical intervention and treatment for high-risk patients.

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Co-infection With Hepatitis B in Tuberculosis Patients on Anti-tuberculosis Treatment and the Final Outcome

Cited by 5 publications

References 18 publications

Seroprevalence of viral hepatitis B, C and E in TB patients from the Republic of Moldova

Seroprevalence of viral hepatitis B, C and E in TB patients from the Republic of Moldova

Importancia del abordaje terapéutico y detección precoz de la coinfección por tuberculosis y hepatitis

A nomogram for predicting mortality of patients initially diagnosed with primary pulmonary tuberculosis in Hunan province, China: a retrospective study

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