Co-infection with ‘Candidatus Neoehrlichia mikurensis’ and Borrelia afzelii in an Ixodes ricinus tick that has bitten a human in Romania

Andersson, Martin; Zaghdoudi-Allan, Nadège; Tamba, Paula; Stefanache, Mircea; Chitimia, Lidia

doi:10.1016/j.ttbdis.2014.05.013

Cited by 26 publications

(21 citation statements)

References 18 publications

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“…It has been detected in Mongolia [12], China [6,12,13], Japan [1,14], Russia [4,5,15,16], the Czech Republic [9,17,18], Slovakia [19][20][21], Moldova [22], Hungary [23][24][25], Austria [18,26], Germany [11,[27][28][29][30][31][32], Switzerland [33][34][35][36][37], Poland [38,39], Romania [40], France [28,41,42], Belgium [43], Italy [44][45][46], Spain [47], The Netherlands [3,42,43,48], and the Scandinavian countries [2,…”

Section: The Agentmentioning

confidence: 99%

Infections with the tick-borne bacterium Candidatus Neoehrlichia mikurensis

Wennerås

2015

Clinical Microbiology and Infection

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Candidatus Neoehrlichia mikurensis, which has rodents as its natural hosts, is an emerging tick-borne pathogen in Europe and Asia. This intracellular bacterium causes the infectious disease neoehrlichiosis. Immunocompromised patients may contract a severe form of neoehrlichiosis with high fever and vascular/thromboembolic events. As it is not detected with routine culture-based methods, neoehrlichiosis is underdiagnosed.

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Section: The Agentmentioning

confidence: 99%

Infections with the tick-borne bacterium Candidatus Neoehrlichia mikurensis

Wennerås

2015

Clinical Microbiology and Infection

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“…This tick-borne bacterium [19–21] has been detected in several mammal species, including humans [22–25]. Previous studies concerning this bacterium have shown that it has the ability to infect dogs [26] and that it is present in ticks in Romania [16, 27]. However, the scale to what this pathogen is infecting dogs has rarely been investigated.…”

Section: Introductionmentioning

confidence: 99%

Canine tick-borne diseases in pet dogs from Romania

et al. 2017

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BackgroundTick-borne diseases are of substantial concern worldwide for animals as well as humans. Dogs have been a human companion for millennia, and their significant impact on human life renders disease in dogs to be of great concern. Tick-borne diseases in dogs represent a substantial diagnostic challenge for veterinarians in that clinical signs are often diffuse and overlapping. In addition, co-infections with two or more pathogens enhance this problem further. Molecular methods are useful to disentangle co-infections and to accurately describe prevalence and geographical distribution of tick-borne diseases. At this point, this information is lacking in many areas worldwide. Romania is one such area, where prevalence and distribution of several important pathogens need to be further investigated. To address this, we screened blood samples from 96 sick dogs with molecular methods for eight different pathogens including Babesia spp., Theileria spp., Hepatozoon spp., Anaplasma spp., Ehrlichia spp., “Candidatus Neoehrlichia mikurensis”, Mycoplasma spp., and Borrelia spp.ResultsAs many as 45% (43/96) of the dogs in the study were infected with protozoan parasites. Babesia canis was the most frequent of these (28 infected dogs), whereas Hepatozoon canis was detected in 15% (14/96) and Babesia gibsoni was found in a single sample. Bacterial infection with Mycoplasma spp. occurred in 18% (17/96) of the sampled dogs. Obtained bacterial sequences revealed the occurrence of two species: Mycoplasma canis and “Candidatus Mycoplasma haematoparvum”. In several cases co-infection with protozoan parasites and Mycoplasma sp. were detected. All dogs were negative for Anaplasma spp., Ehrlichia spp., “Ca. Neoehrlichia mikurensis”, and for Borrelia spp. ConclusionsThe results from the present study reinforce the notion that Babesia canis is an important pathogen in the Romanian dog population. However, more surprisingly, another protozoan species, H. canis, seems to be infecting dogs to a larger extent than previously recognized in Romania. Well-known tick-borne bacterial disease agents such as Anaplasma spp. and Borrelia spp. were not detected. In contrast, less well-studied bacteria such as hemotropic Mycoplasma spp. were detected frequently. Moreover, co-infection might aggravate disease and complicate diagnosis and should be further studied in dogs.

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“…Recently, Candidatus N. mikurensis was detected in an Ix. ricinus tick that had bitten a human in Romania ( 10 ). This recently discovered tickborne agent was shown to be a risk for disease in humans and has been detected in questing Ix.…”

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confidence: 99%