Co-infection paludisme et coronavirus 19 chez les patients admis au service d´infectiologie COVID du Centre Hospitalier Universitaire de Libreville

Igala, Marielle; Bivigou, Elsa Ayo; Kombila, U.D.; Ngoua, S Ntsame; Ngomas, Jean Félix; Mougougou, Adrien; Makao, A Ifoudji; Manomba, C.; Mistoul, Irene; Ebang, Gabrielle Atsame; Mbourou, Anita Akiko; Essandone, Metogho; Pemba, Liliane Flore; Mfoumou, Annick Flore; Loembe, Fifi Claire Ada; Rerambiah, Léonard Kouegnigan; Boguikouma, J. B.; Akotet, Marielle Carine Bouyou

doi:10.11604/pamj.2022.41.101.28751

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Table 1 showed the significant excluded studies with reasons for exclusion: four studies due to non-compatible objectives. Campbell et al (2020) , Bylicka-Szczepanowska & Korzeniewski (2022) , Zhu et al (2022) , Arshad et al (2020) , seven studies with non-compatible study design ( Zhu et al, 2022 ; Zhang et al, 2022 ; Simon-Oke, Awosolu & Odeyemi, 2023 ; Igala et al, 2022 ; Kalungi et al, 2021 ; EBioMedicine, 2021 ; Zawawi et al, 2020 ), other four with non-compatible outcomes ( Arshad et al, 2020 ; Dorkenoo et al, 2022 ; Briggs et al, 2022 ; Wilairatana et al, 2021 ), and single study the publication language is not English ( López-Farfán et al, 2022 ). The identification and screening process sequence was displayed in the PRISMA Flow Diagram ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…3A , 3B , 4A and 4B ). Five studies ( Campbell et al, 2020 ; López-Farfán et al, 2022 ; Igala et al, 2022 ; EBioMedicine, 2021 ; Wilairatana et al, 2021 ) were high-quality, whereas six studies ( JBI, 2020 ; Briggs et al, 2022 ; Kalungi et al, 2021 ; Zawawi et al, 2020 ; Konozy et al, 2022 ; Guha et al, 2021 ) were graded low to moderate quality. Due to the study design, sample size, and consistency of the data as well as the standardized tool to measure the outcomes, the level of certainty was graded low to moderate for the clinical outcomes that tested, i.e ., length of hospital stays, clinical severity and ICU admission and as well as mortality rate ( Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

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COVID-19 and malaria co-infection: a systematic review of clinical outcomes in endemic areas

Mohamed,

Eltyeb,

Said

et al. 2024

PeerJ

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Background COVID-19 and malaria cause significant morbidity and mortality globally. Co-infection of these diseases can worsen their impact on public health. This review aims to synthesize literature on the clinical outcomes of COVID-19 and malaria co-infection to develop effective prevention and treatment strategies. Methods A comprehensive literature search was conducted using MeSH terms and keywords from the start of the COVID-19 pandemic to January 2023. The review included original articles on COVID-19 and malaria co-infection, evaluating their methodological quality and certainty of evidence. It was registered in PROSPERO (CRD42023393562). Results Out of 1,596 screened articles, 19 met the inclusion criteria. These studies involved 2,810 patients, 618 of whom had COVID-19 and malaria co-infection. Plasmodium falciparum and vivax were identified as causative organisms in six studies. Hospital admission ranged from three to 18 days. Nine studies associated co-infection with severe disease, ICU admission, assisted ventilation, and related complications. One study reported 6% ICU admission, and mortality rates of 3%, 9.4%, and 40.4% were observed in four studies. Estimated crude mortality rates were 10.71 and 5.87 per 1,000 person-days for patients with and without concurrent malaria, respectively. Common co-morbidities included Diabetes mellitus, hypertension, cardiovascular diseases, and respiratory disorders. Conclusion Most patients with COVID-19 and malaria co-infection experienced short-term hospitalization and mild to moderate disease severity. However, at presentation, co-morbidities and severe malaria were significantly associated with higher mortality or worse clinical outcomes. These findings emphasize the importance of early detection, prompt treatment, and close monitoring of patients with COVID-19 and malaria co-infection.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

COVID-19 and malaria co-infection: a systematic review of clinical outcomes in endemic areas

Mohamed,

Eltyeb,

Said

et al. 2024

PeerJ

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“…People living in malaria-endemic areas who are infected with SARS-CoV-2 may be at increased risk of severe COVID-19 or adverse disease outcomes if they are unaware of their malaria status (30). Results from literatures show malaria seroprevalence ranging from 3.1% to 40% (2,24,30,31).…”

Section: Discussionmentioning

confidence: 99%

COVID-19 in children aged 0-15 years seen at Amirou Boubacar Diallo National Hospital in Niamey, Niger, 2020-2021

Idé Amadou,

Mahamadou,

Dodo

et al. 2024

Af J Clin Exp Micro

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Background: In 2020, the COVID-19 pandemic affected all age groups. Although COVID-19 is generally benign in children, a diagnostic problem may arise due to clinical similarities with certain pathologies such as malaria, dengue fever and influenza. The objective of this study is to describe the epidemiological profile of COVID 19 in children seen at consultation and to determine the prevalence of influenza, malaria and dengue fever as differential diagnoses. Methodology: We conducted a prospective cohort analytical study from October 1, 2020 to February 28, 2021 in COVID-19 suspected children aged 0 to 15 years admitted to the pediatrics department at the hospital. We used EPI INFO 7.2.4. software for data entry and analysis. Frequencies and proportions were calculated. Results: A total of 570 suspected cases of COVID-19 were enrolled. Of the suspected cases, 53.2% were males and 46.9% were females, with a M/F ratio of 1.13. The median age was 2 years (IQR: 1- 3 years), with age range of 0 to 15 years, and 68,8% in the age range 1 to 5 years. Exposure factors were travel (3.7%), contact with a suspected case of COVID-19 (1.0%), while only 2.6 % (15/570) of suspected cases were confirmed positive for COVID-19. The median age of COVID-19 confirmed children was 2.7 years (IQR 0.33-5). There were more male positive cases, with a M/F ratio of 2. Fever (100%) and cough (53.3%) were the predominant symptoms. The prevalence of malaria, Dengue fever and influenza among suspected COVID-19 cases were 16.8%, 0% and 54.7% respectively, while the respective prevalence in COVID-19 confirmed cases were 66.7%, 0% and 33.3% Conclusion: COVID-19 should be investigated in children presenting with symptoms and signs of malaria, influenza or Dengue fever. Contexte: en 2020, la pandémie de COVID-19 a touché toutes les tranches d’âge. Bien que le COVID-19 soit généralement bénin chez l’enfant, un problème de diagnostic peut surgir en raison de similitudes cliniques avec certaines pathologies comme le paludisme, la dengue et la grippe. L'objectif de cette étude est de décrire le profil épidémiologique du COVID 19 chez les enfants vus en consultation et de déterminer la prévalence de la grippe, du paludisme et de la dengue comme diagnostics différentiels. Méthodologie: Nous avons mené une étude prospective descriptive de cohorte du 1er octobre 2020 au 28 février 2021, chez des enfants suspects de COVID-19 âgés de 0 à 15 ans admis au service de pédiatrie de l'hôpital. Nous avons utilisé EPI INFO 7.2.4. Logiciel de saisie et d'analyse de données. Les fréquences et les proportions ont été calculées. Résultats: Au total, 570 cas suspects de COVID-19 ont été recrutés. Parmi les cas suspects, 53,2% étaient des hommes et 46,9% des femmes, avec un ratio H/F de 1,13. L'âge médian était de 2 ans (IQR: 1-3 ans), avec une tranche d'âge de 0 à 15 ans, et 68,8% dans la tranche d'âge de 1 à 5 ans. Les facteurs d'exposition étaient les voyages (3,7%), le contact avec un cas suspect de COVID-19 (1,0%), tandis que seulement 2,6% (15/570) des cas suspects ont été confirmés positifs à la COVID-19. L'âge médian des enfants confirmés par le COVID-19 était de 2,7 ans (IQR 0,33-5). Il y a eu davantage de cas positifs chez les hommes, avec un ratio H/F de 2. La fièvre (100%) et la toux (53,3%) étaient les symptômes prédominants. La prévalence du paludisme, de la dengue et de la grippe parmi les cas suspects de COVID-19 était respectivement de 16,8%, 0% et 54,7%, tandis que la prévalence respective des cas confirmés de COVID-19 était de 66,7%, 0% et 33,3%. Conclusion: Le COVID-19 doit être recherché chez les enfants présentant des symptômes et des signes de paludisme, de grippe ou de Dengue.

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Malaria and COVID-19 prevalence in a population of febrile children and adolescents living in Libreville

Ditombi

Ngondza²,

Boulingui³

et al. 2022

Southern African Journal of Infectious Diseases

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Background: Patients with acute febrile illness need to be screened for malaria and coronavirus disease 2019 (COVID-19) in malaria-endemic areas to reduce malaria mortality rates and to prevent the transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Objectives: To estimate the frequency of children and adolescents with COVID-19 and/or malaria among febrile patients attending for malaria diagnosisMethod: This cross-sectional study was conducted in a sentinel site for malaria surveillance during the SARS-CoV-2 pandemic (Omicron variant), from October 2021 to December 2021 in Gabon. All febrile patients were tested for malaria using microscopy. Severe acute respiratory syndrome coronavirus 2 was detected by real time polymerase chain reaction (RT-PCR) and rapid antigen tests developed by Sansure Biotech®.Results: A total of 135 patients were screened. Their median age was 6 (interquartile range [IQR]: 3–14) years. Malaria was confirmed for 49 (36.3%) patients, 29 (32.5%) children, 13 (59.0%) adolescents and 7 (29.2%) adults. The frequency of COVID-19 cases was 7.4% (n = 10/135), and it was comparable between children (n = 6; 6.7%), adolescents (n = 2; 9.1%) and adults (n = 2; 8.3%) (p = 0.17). Malaria and COVID-19 co-infections were diagnosed in 3 (6.1%) patients from all the age groups. Participants with a co-infection had a higher median temperature, a higher median parasitaemia, and were mostly infected with non-falciparum malaria.Conclusion: COVID-19 cases and cases of malaria/COVID-19 co-infections were found in febrile children and adolescents. SARS-CoV-2 testing should be included in the screening of suspected malaria cases.Contribution: This study highlights the presence of malaria-COVID-19 coinfection among children and adolescents who should also be screened for both diseases, like for adults.

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Co-infection paludisme et coronavirus 19 chez les patients admis au service d´infectiologie COVID du Centre Hospitalier Universitaire de Libreville

Cited by 3 publications

References 17 publications

COVID-19 and malaria co-infection: a systematic review of clinical outcomes in endemic areas

COVID-19 and malaria co-infection: a systematic review of clinical outcomes in endemic areas

COVID-19 in children aged 0-15 years seen at Amirou Boubacar Diallo National Hospital in Niamey, Niger, 2020-2021

Malaria and COVID-19 prevalence in a population of febrile children and adolescents living in Libreville

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