Co-infection of human parvovirus B19 in Vietnamese patients with hepatitis B virus infection

Toàn, Nguyễn Lĩnh; Song, Lê Hữu; Kremsner, Peter G.; Duy, Dinh N.; Binh, Vu Q.; Duechting, Anja; Kaiser, Heike; Torresi, Joseph; Kandolf, Reinhard; Bock, C.‐Thomas

doi:10.1016/j.jhep.2006.03.013

Cited by 28 publications

(26 citation statements)

References 46 publications

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“…This might indicate that the degree of genetic diversity among the genotype 2 viruses is similar to that observed among genotypes 3 and 1 viruses (Toan et al, 2006;Parsyan et al, 2007).…”

Section: Discussionsupporting

confidence: 53%

Simultaneous persistence of multiple genome variants of human parvovirus B19

Schneider

Höne

Tolba

et al. 2008

Journal of General Virology

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The species human parvovirus B19 (B19V) can be divided into three genotypes. In this study, we addressed the question as to whether infection of an individual is restricted to one genotype. As viral DNA is detectable in tissue for long times after acute infection, we examined 87 liver specimens from adults for the presence of B19V DNA. Fifty-nine samples were found to be positive, 32 of them for genotype 1, 27 for genotype 2 and four for genotype 3. In four samples, DNA of two genotypes was detected; samples from three individuals were positive for genotypes 1 and 2 and a sample from one individual was positive for genotypes 1 and 3. Surprisingly, significant sequence heterogeneity was observed at approximately 1 % of the nucleotides of the genotype 1 genomes from individuals with double genotype 1 and 2 infection. Controls using different enzymes for genome amplification and dilutions of the template verified that nucleotide heterogeneity was due to the presence of three or more genome variants of genotype 1. In summary, the evidence shows that individuals can be infected with two different genotypes, and B19V DNA can persist as a population of different genomes. The results may have implications for the understanding of the antiviral immune response and the development of vaccines against B19V.

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“…This might indicate that the degree of genetic diversity among the genotype 2 viruses is similar to that observed among genotypes 3 and 1 viruses (Toan et al, 2006;Parsyan et al, 2007).…”

Section: Discussionsupporting

confidence: 53%

Simultaneous persistence of multiple genome variants of human parvovirus B19

Schneider

Höne

Tolba

et al. 2008

Journal of General Virology

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“…Previous studies have suggested a significant correlation between HBV and parvovirus B19 co-infection [14,15] while PARV4 was originally detected in a HBV infected patient, raising the possibility of an association with HBV infection [2,16]. The frequency of PARV4 DNA detection was significantly higher among HBV infected subjects than matched healthy controls, which is in agreement with our previous study [5] and similar to results from a cohort of hemodialysis and lung transplant patients [17].…”

Section: Discussionsupporting

confidence: 91%

PARV4 Co-Infection is Associated with Disease Progression in HBV Patients in Shanghai.

Wang

Zhao

et al. 2015

J Med Diagn Meth

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Human parvovirus 4 (PARV4) has been detected in blood and tissue samples from HIV/AIDS patients who are injecting drug users and we have reported PARV4 co-infection of hepatitis B or hepatitis C virus (HBV, HCV) infected individuals. In this study, we have investigated the consequences of co-infection with PARV4 for HBV infected individuals.The aim of this study was to investigate the consequences of co-infection with PARV4 for HBV infected individuals.Serum samples from healthy controls and HBV infected subjects were retrieved from Shanghai Center for Disease Control and Prevention Sample Bank. HBV genotypes were determined and sequences compared with reference sequences to derive phylogeny trees. All samples were tested for PARV4, parvovirus B19 and HCV; serum alanine transaminase (ALT) in chronic HBV patients was used as an indicator of disease severity. Relevant cytokines were measured in sera from healthy controls and HBV carriers.HBV infected subjects had higher prevalence of PARV4 compared to healthy controls. PARV4 prevalence was not associated with HBV genotype, negatively correlated with serum HBV DNA, but positively correlated with serum ALT level. Additionally, serum IL-8 was up-regulated in HBV carriers co-infected with PARV4.Co-infection with PARV4 may increase the risk of liver disease in HBV patients through up-regulation of inflammatory cytokines, but the underlying mechanism remains to be elucidated.

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“…In spite of the short duration of viremia, the virus is detectable for a long time in the tissue, causing a latent infection with PARV4 (13,14,20). In the present study, considering the results of previous studies that indicate a significant association between B19 and hepatitis B and C viruses (21,22), and also according to the possibility of PARV4 related with these viruses, we compared the prevalence of PARV4 viremia in healthy subjects and HBV-infected individuals and determined its genotype in positive cases.…”

Section: Introductionmentioning

confidence: 51%

Frequency of human parvovirus 4 (PARV4) viremia among HBV-infected patients and healthy donors in Shiraz, Iran

et al. 2017

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Background/aim: PARV4, a small DNA virus belonging to the family Parvoviridae, was first isolated in an HBV injecting drug user. Several studies have investigated PARV4 co-infection with HBV and HCV and its effect on the progression of liver disease. The aim of this study was to determine the frequency of PARV4 among HBV-infected patients and healthy individuals. Materials and methods:A group of 90 HBV patients and a group of 90 healthy subjects were included in this study. Samples were selected after screening tests such as HBsAg ELISA, anti-HCV ELISA, and anti-HIV ELISA. Nested-PCRs were conducted to detect the PARV4 genome. Positive samples were then subjected to DNA sequencing.Results: PARV4 DNA was detected in 4.4% of HBV patients in comparison with 1.1% of healthy individuals (P-value: 0.36). DNA sequencing results revealed that PARV4 in all five positive samples was genotype I.Conclusions: Although this pilot study showed no significant difference between the frequency of PARV4 among HBV patients and healthy donors, further studies with a larger sample size are suggested to determine the association of PARV4 with HBV co-infection and the impact of this virus on the progression of liver disease in patients with hepatitis B.

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Co-infection of human parvovirus B19 in Vietnamese patients with hepatitis B virus infection

Cited by 28 publications

References 46 publications

Simultaneous persistence of multiple genome variants of human parvovirus B19

Simultaneous persistence of multiple genome variants of human parvovirus B19

PARV4 Co-Infection is Associated with Disease Progression in HBV Patients in Shanghai.

Frequency of human parvovirus 4 (PARV4) viremia among HBV-infected patients and healthy donors in Shiraz, Iran

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