Co-infection of COVID-19 and pneumocystosis in the patient after kidney transplantation

Skonieczny, Piotr; Heleniak, Zbigniew; Szostakiewicz, Maria; Krzemieniecki, Krzysztof; Dębska‐Ślizień, Alicja

doi:10.20452/pamw.15996

Cited by 8 publications

(6 citation statements)

References 3 publications

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“…Apart from Aspergillosis [10], opportunistic mycoses such as Pneumocystosis have been increasingly described in COVID-19 patients, especially in those suffering HIV [11][12][13]. The remaining cases of co-infection have been reported in patients with malignancies [14,15] and kidney-transplant recipients [16,17].…”

Section: Discussionmentioning

confidence: 99%

“…One case was in a 47-year-old man in Poland [16], who was taking cyclosporine for immunosuppressive treatment, and developed acute kidney injury caused by an interaction between cyclosporine and clarithromycin. The degree of immunosuppression is unclear, as exact lymphocyte counts are not disclosed.…”

Section: Discussionmentioning

confidence: 99%

“…Although cases of COVID-19 and concurrent Pneumocystis infection have been reported, ref. [11][12][13][14][15][16][17]22] fungal co-infection in COVID-19 patients seem to be underestimated in a clinical setting [22]. The diagnosis and differentiation of COVID and PJP poses a diagnostic challenge, because of numerous overlapping clinical and radiologic features [11,25,26].…”

Section: Discussionmentioning

confidence: 99%

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Co-Infection of COVID-19 and Pneumocystosis Following Rituximab Infusion—A Case Report

et al. 2022

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Immunocompromised patients with respiratory viral infections are at increased risk of fungal superinfections, including Pneumocystosis. Within the scope of the COVID-19 pandemic, Pneumocystis jirovecii co-infections are being increasingly reported. Differential diagnosis often creates a dilemma, due to multiple overlapping clinical and radiographic features. Awareness of fungal co-infections in the context of the COVID-19 pandemic is crucial to initiate prophylactic measures, especially in high-risk individuals. We report the second case of Pneumocystis jirovecii pneumonia and COVID-19 co-infection in a renal transplant recipient in Poland.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Co-Infection of COVID-19 and Pneumocystosis Following Rituximab Infusion—A Case Report

et al. 2022

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“…There have been approximately 100 reports of coinfection of P. jirovecii in COVID-19 patients, with some of them reviewed recently by Gioia et al [ 226 ] and Khodadadi et al [ 227 ]. The largest number of coinfection cases (in non-HIV/AIDS) was reported from France (34 cases), followed by Italy (22 cases) and Pakistan (10 cases) ( Figure 3 and Table S3 [ 15 , 224 , 225 , 226 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 235 , 236 , 237 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 , 270 , 271 ]).…”

Section: Immunodeficient Conditions and Risk Factors For Pcpmentioning

confidence: 99%

Trends in the Epidemiology of Pneumocystis Pneumonia in Immunocompromised Patients without HIV Infection

Xue,

Kong,

2023

JoF

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The increasing morbidity and mortality of life-threatening Pneumocystis pneumonia (PCP) in immunocompromised people poses a global concern, prompting the World Health Organization to list it as one of the 19 priority invasive fungal diseases, calling for increased research and public health action. In response to this initiative, we provide this review on the epidemiology of PCP in non-HIV patients with various immunodeficient conditions, including the use of immunosuppressive agents, cancer therapies, solid organ and stem cell transplantation, autoimmune and inflammatory diseases, inherited or primary immunodeficiencies, and COVID-19. Special attention is given to the molecular epidemiology of PCP outbreaks in solid organ transplant recipients; the risk of PCP associated with the increasing use of immunodepleting monoclonal antibodies and a wide range of genetic defects causing primary immunodeficiency; the trend of concurrent infection of PCP in COVID-19; the prevalence of colonization; and the rising evidence supporting de novo infection rather than reactivation of latent infection in the pathogenesis of PCP. Additionally, we provide a concise discussion of the varying effects of different immunodeficient conditions on distinct components of the immune system. The objective of this review is to increase awareness and knowledge of PCP in non-HIV patients, thereby improving the early identification and treatment of patients susceptible to PCP.

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“…The coronavirus disease 2019 (COVID-19) has become an unprecedented threat to solid-organ transplant (SOT) recipients, with excessive mortality observed in infected patients [ 1 ]. These immunocompromised patients with frequent comorbidities easily get COVID-19 and are at high risk of developing concomitant infections [ 2 , 3 ]. Additionally, their response to COVID-19 vaccine may be suboptimal [ 4 ].…”

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confidence: 99%

Life-threatening COVID-19 and aspergillosis co-infection in a heart transplant recipient: A cardiologist’s nightmare

et al. 2022

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Co-infection of COVID-19 and pneumocystosis in the patient after kidney transplantation

Cited by 8 publications

References 3 publications

Co-Infection of COVID-19 and Pneumocystosis Following Rituximab Infusion—A Case Report

Co-Infection of COVID-19 and Pneumocystosis Following Rituximab Infusion—A Case Report

Trends in the Epidemiology of Pneumocystis Pneumonia in Immunocompromised Patients without HIV Infection

Life-threatening COVID-19 and aspergillosis co-infection in a heart transplant recipient: A cardiologist’s nightmare

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