Co-infection of  Candida parapsilosis  in  a Patient of Pulmonary Actinomycosis-A  Rare Case Report

Ghosh, Purbasha; Gupta, Indrajit; Kar, Mousumi; Nandi, Poulami; Naskar, Prosenjit

doi:10.7860/jcdr/2017/24268.9300

Cited by 5 publications

(5 citation statements)

References 6 publications

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“…While there are several reports of Candida and Actinomyces co-infection resulting in esophageal or pulmonary infection, only one noted the formation of a fistula (Table 5) [17]. Like tuberculosis, actinomycosis causes chronic granulomatous inflammation, which may have contributed to the fistula formation in our patient [15,16]. Actinomyces is a known etiology of mycetoma, chronic granulomatous infections that are classically difficult to treat and require prolonged therapy [8,9].…”

Section: Candida and Actinomycesmentioning

confidence: 81%

“…published cases of TEF caused by Candida (Tables 3 and 4); seven individual reports and two reviews note Candida coinfection with Actinomyces, six of which confirmed the infections by culture (Tables 5 and 6). Candida and Actinomyces species can be found in the oral mucosa, often found in dental plaques and among normal mouth flora, typically causing infection in individuals with impaired mucosal barriers or compromised immune systems [15,16]. While isolated Candida infections can occur, Actinomyces rarely is the sole culprit of infection, instead, it is often part of a microbial infection in conjunction with other species like Streptococcus, Fusobacterium, or Candida [15,16].…”

Section: Candida and Actinomycesmentioning

confidence: 99%

“…Candida and Actinomyces species can be found in the oral mucosa, often found in dental plaques and among normal mouth flora, typically causing infection in individuals with impaired mucosal barriers or compromised immune systems [15,16]. While isolated Candida infections can occur, Actinomyces rarely is the sole culprit of infection, instead, it is often part of a microbial infection in conjunction with other species like Streptococcus, Fusobacterium, or Candida [15,16]. While there are several reports of Candida and Actinomyces co-infection resulting in esophageal or pulmonary infection, only one noted the formation of a fistula (Table 5) [17].…”

Section: Candida and Actinomycesmentioning

confidence: 99%

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Tracheoesophageal fistula due to Candida and Actinomyces co-infection: A case report and comprehensive review of the literature

Teshon,

Reyes,

Schammel

et al. 2024

EuJMI

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Acquired benign tracheoesophageal fistulas and bronchoesophageal fistulas (TEF) are typically associated with granulomatous mediastinal infections, 75% of which are iatrogenic. Candida albicans and Actinomyces are commonly occurring organisms, but are uncommon etiologies of TEF. Normal colonization and the slow growth characteristics of some species of these agents rarely result in infection, mycetoma, and broncholithiasis, and thus, delays in diagnosis and treatment are likely. Few reports describe C. albicans or Actinomyces spp. as the etiology of TEF or broncholithiasis. Herein, we report a case of benign acquired TEF secondary to coinfection of Candida and Actinomyces complicated by the formation of an actinomycetoma and broncholithiasis and a comprehensive literature review to highlight the unique nature of this presentation and offer a diagnostic algorithm for diagnosis and treatment of TEFs. Following a presentation of three months of productive cough, choking sensation, night sweats, and weight loss, a bronchoscopy revealed a fistulous connection between the esophagus and the posterior right middle lobe. Pathology identified a calcified fungus ball and a broncholith secondary to the co-infection of Candida and Actinomyces. This unique presentation of Candida and Actinomyces co-infection and the associated diagnostic algorithm are presented as education and a useful tool for clinicians.

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Section: Candida and Actinomycesmentioning

confidence: 81%

Section: Candida and Actinomycesmentioning

confidence: 99%

Section: Candida and Actinomycesmentioning

confidence: 99%

See 1 more Smart Citation

Tracheoesophageal fistula due to Candida and Actinomyces co-infection: A case report and comprehensive review of the literature

Teshon,

Reyes,

Schammel

et al. 2024

EuJMI

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“…While pulmonary actinomycosis can clinically mimic other pulmonary infections (e.g. nocardiosis, aspergillosis, tuberculosis) or even malignancy [24,[29][30][31][32][33], it is important to be aware that co-infections with other microorganisms creating lung masses have also been described [34][35][36][37]. Aspiration of oropharyngeal secretions or the presence of a foreign body in the bronchial tree seems to be the main cause of pulmonary actinomycosis.…”

Section: Pulmonary Actinomycosis Is An Uncommon Disease Especially In Developed Countriesmentioning

confidence: 99%

Pulmonary actinomycosis: cytomorphological features

Martínez‐Girón¹,

Pantanowitz

2021

Monaldi Arch Chest Dis

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Pulmonary actinomycosis is an uncommon infectious disease. Although the gold standard for diagnosis is histological examination with bacterial culture of lung tissue, cytology samples offer a fast and low-cost alternate diagnostic procedure. The cytology literature on this topic is limited to mostly case reports. Therefore, the aim of this study was to review cytological material in a series of patients with a diagnosis of pulmonary actinomycosis to characterize the main cytomorphological findings. Different cytological respiratory samples including sputum smears, bronchoalveolar lavages (BALs), transthoracic or endobronchial fine needle aspiration cytology (FNAC) and cell block preparations were used for retrospective examination. For all cases patient age, gender, symptoms, and radiological chest findings were recorded. A total of 26 cytological respiratory samples (14 sputum smears, 9 FNAC, two BALs) including direct smears and 6 cell blocks from 9 patients were examined. In sputum smears the most remarkable findings were the presence of dark cotton ball masses with projections like spider legs and/or mouse tails (75% of the samples). Sulfur granules were observed in 4 (40%) of the sputum smears and within FNAC cases. Various respiratory cytology samples including sputum smears, FNAC and BALs can reveal cytomorphological findings diagnostic of pulmonary actinomycosis. Characteristic cytological findings compatible with a diagnosis of this infection include cotton ball masses and less frequently sulfur granules.

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“…Actinomyces are lamentous Gram-positive obligate anaerobic bacteria. Actinomycosis is classically divided into three types according to the sites involved: cervicofacial (55%), abdominopelvic (20%) and thoracic(15%) [1][2].Pulmonary actinomycosisis as a rare infection is commonly confused with other lung diseases, such as lung cancer, tuberculosis, pneumonia and aspergillosis [3][4][5].Pulmonary actinomycosis, with Fungus and/or tuberculosis co-infection is rare although the numbers of cases are increasing [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary actinomycosis with polymicrobial co-infection presenting as pulmonary abscess：a case report

Song¹,

He²,

Xiong³

2023

Preprint

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Background: Pulmonary actinomycosis is very rare. It is often misdiagnosed as lung cancer, tuberculosis, pulmonary aspergillosis or pulmonary abscess. Predisposing factors are immunosuppressive conditions, poor oral hygiene and chronic lung disease. Co-infection with different strains of actinomycetes, aspergillus and bacteria is rarely reported, which is a major cause of treatment failure. Case presentation：We reported a case of 63-year old woman with 3-month history of cough, expectoration and occasional hemoptysis. Pulmonary actinomycosis with polymicrobial co-infection including actinomyces mucous, actinomyces graevenitzii, aspergillus, klebsiella pneumoniae and streptococcus constellations in left inferior lobe was confirmed by etiological culture. Combined antibiotic therapy and bronchoalveolar lavage were administrated successfully. The clinical symptoms and radiologic abnormalities had improved significantly. Conclusions:Pulmonary actinomycosis is often misdiagnosed because of the nonspecific clinical manifestations and laboratory tests.Bronchoscopy plays a key role in the diagnostic and therapeutic pathways. Co-infection make the treatment more difficult. This case improves our understanding of the diagnosis and comprehensive therapeutic strategies for pulmonary actinomycosis with polymicrobial co-infection in the elderly.

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Co-infection of Candida parapsilosis in a Patient of Pulmonary Actinomycosis-A Rare Case Report

Cited by 5 publications

References 6 publications

Tracheoesophageal fistula due to Candida and Actinomyces co-infection: A case report and comprehensive review of the literature

Tracheoesophageal fistula due to Candida and Actinomyces co-infection: A case report and comprehensive review of the literature

Pulmonary actinomycosis: cytomorphological features

Pulmonary actinomycosis with polymicrobial co-infection presenting as pulmonary abscess：a case report

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