Co-infection by Streptococcus anginosus and Mycobacterium tuberculosis: three case reports

Rey, Ramón Rabuñal; Corredoira, Juan; Monte, Rafael; Coira, Amparo

doi:10.1186/1752-1947-3-37

Cited by 8 publications

(11 citation statements)

References 9 publications

(7 reference statements)

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“…It was reported that S. anginosus infections might simulate tuberculosis [37]. Indeed, three cases of co-infection by S. anginosus and M. tuberculosis were reported previously [38]. P. micra is a Gram-positive anaerobe usually isolated from the human oral cavity.…”

Section: Discussionmentioning

confidence: 99%

Sputum Microbiota in Tuberculosis as Revealed by 16S rRNA Pyrosequencing

et al. 2013

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BackgroundTuberculosis (TB) remains a global threat in the 21st century. Traditional studies of the disease are focused on the single pathogen Mycobacterium tuberculosis. Recent studies have revealed associations of some diseases with an imbalance in the microbial community. Characterization of the TB microbiota could allow a better understanding of the disease.Methodology/Principal FindingsHere, the sputum microbiota in TB infection was examined by using 16S rRNA pyrosequencing. A total of 829,873 high-quality sequencing reads were generated from 22 TB and 14 control sputum samples. Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria, and Fusobacteria were the five major bacterial phyla recovered, which together composed over 98% of the microbial community. Proteobacteria and Bacteroidetes were more represented in the TB samples and Firmicutes was more predominant in the controls. Sixteen major bacterial genera were recovered. Streptococcus, Neisseria and Prevotella were the most predominant genera, which were dominated by several operational taxonomic units grouped at a 97% similarity level. Actinomyces, Fusobacterium, Leptotrichia, Prevotella, Streptococcus, and Veillonella were found in all TB samples, possibly representing the core genera in TB sputum microbiota. The less represented genera Mogibacterium, Moryella and Oribacterium were enriched statistically in the TB samples, while a genus belonging to the unclassified Lactobacillales was enriched in the controls. The diversity of microbiota was similar in the TB and control samples.Conclusions/SignificanceThe composition and diversity of sputum microbiota in TB infection was characterized for the first time by using high-throughput pyrosequencing. It lays the framework for examination of potential roles played by the diverse microbiota in TB pathogenesis and progression, and could ultimately facilitate advances in TB treatment.

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Section: Discussionmentioning

confidence: 99%

Sputum Microbiota in Tuberculosis as Revealed by 16S rRNA Pyrosequencing

et al. 2013

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“…However, this is a quite rare occurrence in immunocompetent patients, being much more common in HIVinfected subjects who are at higher risk of pneumococcal infection (i.e. the most frequent co-infecting agent) [6].…”

Section: Discussionmentioning

confidence: 99%

“…Simultaneous infections with MTB and other agents is rare, typically involve S. pneumoniae and are most commonly reported among HIV-infected patients [1]. Clinically, the isolation of SAG co-infection with MTB has not been described in pediatric patients [6]. In this report, we describe a case of an abscess caused by the duality SAG-MTB coinfection in a pediatric immunocompetent.…”

Section: Introductionmentioning

confidence: 98%

Co-infection with Streptococcus anginosus and Mycobacterium tuberculosis in an immunocompetent pediatric patient. A case report

Saldaña¹,

Bejarano²,

Porras³

et al. 2020

BMC Pulm Med

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Background: Simultaneous infection in tuberculosis (TB) is rare. The mixed infection between Streptococcus anginosus group (SAG) and M. tuberculosis (MTB) has not been reported in children. The aim of this report was to describe a pediatric case with a pulmonary abscess caused by the duality SAG-MTB co-infection. Case presentation: An 11-year-old boy with an acute onset of throbbing pain of two-day evolution located in the anterior chest wall. The patient reported a history of fever, cough and rhinorrhea during the last seven days. An anterior chest radiography revealed a heterogenic opacity at the lower right lobe while the lateral projection showed an obliteration at the anterior diaphragmatic insertion. Parenteral Ceftriaxone (100 mg/kg/day) and Dicloxacillin (200 mg/kg/day) was started. The abscess was subsequently drained and analyzed. After a year of follow-up, the patient remained asymptomatic. Conclusion: This case represents the first reported case of pulmonary co-infection involving MTB and SAG in an immunocompetent pediatric patient.

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“…Gleichzeitige Infektionen mit MTB und anderen Erregern sind selten, treten meist unter Beteiligung von S. pneumoniae auf und werden am häufigsten bei Patienten mit HIV-Infektion berichtet [1]. Der Nachweis einer SAG-Koinfektion mit MTB wurde bei pädiatrischen Patienten bislang klinisch nicht beschrieben [6]. Im vorliegenden Fallbericht schildern wir eine Abszessbildung verursacht durch eine SAG-MTB-Doppelinfektion bei einem immunkompetenten pädiatrischen Patienten.…”

Section: Hintergrundunclassified

“…Allerdings treten sie bei immunkompetenten Patienten eher selten auf. Bei Patienten mit HIV-Infektion sind sie sehr viel häufiger, da deren Risiko für eine Infektion mit Pneumokokken (dem häufigsten Koinfektionserreger) höher ist [6].…”

Section: Diskussionunclassified

Koinfektion mit Streptococcus anginosus und Mycobacterium tuberculosis bei einem immunkompetenten pädiatrischen Patienten. Ein Fallbericht

González-Saldaña¹,

Bejarano²,

Hernández-Porras³

et al. 2020

Kompass Pneumol

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Hintergrund: Koinfektionen bei Tuberkulose (TB) sind selten. Eine Mischinfektion mit der Streptococcus-anginosus-Gruppe (SAG) und M. tuberculosis (MTB) wurde bei Kindern bislang noch nicht berichtet. Ziel dieses Berichts war die Beschreibung eines pädiatrischen Falls mit Lungenabszess infolge einer SAG-MTB-Doppelinfektion. Fallvorstellung: Ein 11-jähriger Junge mit vor zwei Tagen akut aufgetretenen pulsierenden Schmerzen in der vorderen Brustwand. Der Patient berichtet über Fieber, Husten und Nasenlaufen in den vergangenen sieben Tagen. Die anteriore Thorax-Röntgenaufnahme ergab eine heterogene Verschattung am rechten Unterlappen, und die laterale Projektion zeigte eine Obliteration an der vorderen Zwerchfellinsertion. Die parenterale Gabe von Ceftriaxon (100 mg/ kg/Tag) und Dicloxacillin (200 mg/kg/Tag) wurde eingeleitet. Der Abszess wurde anschließend drainiert und analysiert. Nach einjähriger Nachbeobachtung blieb der Patient weiterhin asymptomatisch. Schlussfolgerung: Dies ist unseres Wissens der erste berichtete Fall einer pulmonalen Koinfektion mit MTB und SAG bei einem immunkompetenten pädiatrischen Patienten.

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Co-infection by Streptococcus anginosus and Mycobacterium tuberculosis: three case reports

Cited by 8 publications

References 9 publications

Sputum Microbiota in Tuberculosis as Revealed by 16S rRNA Pyrosequencing

Sputum Microbiota in Tuberculosis as Revealed by 16S rRNA Pyrosequencing

Co-infection with Streptococcus anginosus and Mycobacterium tuberculosis in an immunocompetent pediatric patient. A case report

Koinfektion mit <i>Streptococcus anginosus</i> und <b><i>Mycobacterium tuberculosis</i></b> bei einem immunkompetenten pädiatrischen Patienten. Ein Fallbericht

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