Co-immobilization of adhesive peptides and VEGF within a dextran-based coating for vascular applications

Noel, Samantha Joan; Fortier, Charles; Murschel, Frédéric; Belzil, Antoine; Gaudet, Guillaume; Jolicœur, Mario; Crescenzo, Grégory De

doi:10.1016/j.actbio.2016.03.043

Cited by 50 publications

(73 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, without the addition of cell adhesion ligands dextran does not support cell attachment and proliferation. High abundance hydroxyl groups on dextran allow addition of functional peptides through derivatization and crosslinking reactions . A recent study demonstrated that grafting of RGD peptide at a concentration as low as 0.1% shows comparable cell survival to dextran containing 10% RGD .…”

Section: Moving From 3d Cell‐entrapment Devices To Cell‐modulation Plmentioning

confidence: 99%

Toward Customized Extracellular Niche Engineering: Progress in Cell‐Entrapment Technologies

2017

View full text Add to dashboard Cite

The primary aim in tissue engineering is to repair, replace, and regenerate dysfunctional tissues to restore homeostasis. Cell delivery for repair and regeneration is gaining impetus with our understanding of constructing tissue‐like environments. However, the perpetual challenge is to identify innovative materials or re‐engineer natural materials to model cell‐specific tissue‐like 3D modules, which can seamlessly integrate and restore functions of the target organ. To devise an optimal functional microenvironment, it is essential to define how simple is complex enough to trigger tissue regeneration or restore cellular function. Here, the purposeful transition of cell immobilization from a cytoprotection point of view to that of a cell‐instructive approach is examined, with advances in the understanding of cell–material interactions in a 3D context, and with a view to further application of the knowledge for the development of newer and complex hierarchical tissue assemblies for better examination of cell behavior and offering customized cell‐based therapies for tissue engineering.

show abstract

Section: Moving From 3d Cell‐entrapment Devices To Cell‐modulation Plmentioning

confidence: 99%

Toward Customized Extracellular Niche Engineering: Progress in Cell‐Entrapment Technologies

2017

View full text Add to dashboard Cite

show abstract

“…[26,73] Some of the most recent reports on the subject have successfully bound GFs on several polymeric biomaterials, including stem cell factor (SCF), [74] transforming growth factor beta 1 (TGF-β1), [72,75] EGF, [76][77][78][79] FGF-2, [76] nerve growth factor (NGF), [80] or VEGF. [81] Modification of gelatin with methacryloyl moieties, known as GelMA, allows the application of mild photopolymerization techniques for crosslinking. Photo-crosslinking minimizes the use of toxic agents or aggressive conditions which could damage or compromise protein stability.…”

Section: Materials With Covalently Bound Gfsmentioning

confidence: 99%

“…Several groups explored it to conjugate VEGF to scaffolding biomaterials designed to promote vasculogenesis, a key process to increase graft survival. [81,83] For example, VEGF was conjugated to a maleimide-functionalized PEG hydrogel to improve the survival of transplanted pancreatic islet grafts. [83] Among the tested host sites, epididymal fat pads showed the most vascularization and least inflammation.…”

Section: Materials With Covalently Bound Gfsmentioning

confidence: 99%

Biomaterials for Sequestration of Growth Factors and Modulation of Cell Behavior

Teixeira

Domingues

Shevchuk

et al. 2020

Adv Funct Materials

View full text Add to dashboard Cite

Growth factors (GFs) are proteins secreted by cells that regulate a variety of biological processes. Although they have long been proposed as potent therapeutic agents, their administration in a soluble form has proven costly and ineffective due to their short half-lives in biological environments. Biomaterial-based approaches are increasingly sought as alternatives to improve the efficacy or, ideally, replace the need for exogenous administration of GFs in regenerative medicine strategies. The means by which these systems evolve from biomaterials for conventional controlled release of GFs to the recent extracellular matrix (ECM)-inspired approaches for sequestering these labile molecules and regulating their spatiotemporal activity and presentation are reviewed. Focus is placed on biomaterials functionalized either with ECM components, which show promiscuous GF binding, or with targeted GF ligands (antibodies, aptamers, or peptides). The potential of synthetic platforms with abiotic affinity as cost-effective alternatives to the current biological ligands is also discussed. Overall, the various GF sequestering systems developed so far have remarkably improved the activity of GFs at reduced doses and, in some cases, completely avoided the need for their exogenous administration to guide cell fates. These bioinspired concepts thus enable the rational exploration of the full therapeutic potential of GFs in regenerative medicine.

show abstract

“…A promising approach to overcome this shortcoming is the chemical immobilization of the growth factors. [258][259][260] The covalent immobilization of heparin, SDF-1 , and anti-CD47 on elastic PTFE surface augmented the antithrombogenicity, endothelialization and anti-inflammation. [261] PDA has widely been utilized to conjugate growth factors owing to its excellent binding ability.…”

Section: Chemical Approachmentioning

confidence: 99%

Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

Zhao

Feng

2020

Adv Healthcare Materials

View full text Add to dashboard Cite

Cardiovascular devices have been widely applied in the clinical treatment of cardiovascular diseases. However, poor hemocompatibility and slow endothelialization on their surface still exist. Numerous surface engineering strategies have mainly sought to modify the device surface through physical, chemical, and biological approaches to improve surface hemocompatibility and endothelialization. The alteration of physical characteristics and pattern topographies brings some hopeful outcomes and plays a notable role in this respect. The chemical and biological approaches can provide potential signs of success in the endothelialization of vascular device surfaces. They usually involve therapeutic drugs, specific peptides, adhesive proteins, antibodies, growth factors and nitric oxide (NO) donors. The gene engineering can enhance the proliferation, growth, and migration of vascular cells, thus boosting the endothelialization. In this review, the surface engineering strategies are highlighted and summarized to improve hemocompatibility and rapid endothelialization on the cardiovascular devices. The potential outlook is also briefly discussed to help guide endothelialization strategies and inspire further innovations. It is hoped that this review can assist with the surface engineering of cardiovascular devices and promote future advancements in this emerging research field.

show abstract

Co-immobilization of adhesive peptides and VEGF within a dextran-based coating for vascular applications

Cited by 50 publications

References 80 publications

Toward Customized Extracellular Niche Engineering: Progress in Cell‐Entrapment Technologies

Toward Customized Extracellular Niche Engineering: Progress in Cell‐Entrapment Technologies

Biomaterials for Sequestration of Growth Factors and Modulation of Cell Behavior

Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

Contact Info

Product

Resources

About