Co(III) and Ni(II) complexes of an anthracene appended aroyl hydrazone: Synthesis, crystal structures, DNA binding and catecholase activity

Mondal, Satyajit; Pakhira, Bholanath; Blake, Alexander J.; Drew, M. G. B.; Chattopadhyay, Shyamal Kumar

doi:10.1016/j.poly.2016.05.052

Cited by 47 publications

(23 citation statements)

References 69 publications

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“…However, in the present case a reverse trend is observed. In fact, the Ni-N distance in this complex is comparatively longer than that normally observed for octahedral Ni(II) complexes of aroylhydrazones, 28,52 but it is very similar to that reported for an anthracene aldehyde Schiff base complex of Ni(II), 29 and the steric bulk of the naphthalene moiety may be responsible for this relatively longer Ni-N bond. The N6-Ni1-N5 angle (bite angle of phen) is 77.81 (8) , whereas for the hydrazone ligand, the bite angles lie in the range 77.00(6) to 77.88 (6) .…”

supporting

confidence: 81%

“…28 In addition, the use of heterocyclic diimine as the co-ligand in ternary complexes is of considerable interest because some of the diimine containing nickel and cobalt complexes exhibit interesting biological as well as pharmacological properties. 29 The pivotal role of diimine ligands in antitumour activities have been claried by numerous literatures earlier. 30,31 Overall, it has been demonstrated that physicochemical features, such as planarity, hydrophobicity, and size of the diimine, the nature of the co-ligand, and the coordination geometry of the metal complex, all played important roles in determining the binding mode of transition metal complexes to DNA.…”

Section: -25mentioning

confidence: 99%

“…Between À1.5 to À2.0 V, reductive waves are observed, which correspond to reductions of the phen ligand. 29 The single-electron nature of the voltammograms was conrmed by a comparison of the current heights for the complexes and that for a simple [NiL 2 ] complex (where L ¼ thiophene aldehyde benzhydrazone) under identical conditions. 15 The redox potentials were virtually independent of the scan rates, which indicates quasi-reversibility.…”

Section: Electrochemical Studiesmentioning

confidence: 99%

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Ni(ii) and Co(ii) complexes of an asymmetrical aroylhydrazone: synthesis, molecular structures, DNA binding, protein interaction, radical scavenging and cytotoxic activity

Yang

Zhou

et al. 2017

RSC Adv.

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supporting

confidence: 81%

Section: -25mentioning

confidence: 99%

Section: Electrochemical Studiesmentioning

confidence: 99%

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Ni(ii) and Co(ii) complexes of an asymmetrical aroylhydrazone: synthesis, molecular structures, DNA binding, protein interaction, radical scavenging and cytotoxic activity

Yang

Zhou

et al. 2017

RSC Adv.

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“…Focusing to cobalt(III) complexes of N 2 O donor Schiff bases, exploration of their nonlinear optical properties is a growing research topic, owing to the wide availability of metal sources and the structural flexibility of ligands . Cobalt(III) Schiff base complexes are also important in bioinorganic chemistry for important catalytic and biological activities . For example, the roll of such complexes in mimicking several enzymes, e. g. catechol oxidase, phenoxazinone synthase etc is well established .…”

Section: Introductionmentioning

confidence: 99%

Two Cobalt(III) Schiff Base Complexes of the Type [Co(ABC)(DE)X]: Facile Synthesis, Characterization, Catechol Oxidase and Phenoxazinone Synthase Mimicking Activity

2017

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Two new mononuclear cobalt(III) Schiff base complexes with azide or thiocyanate [Co(L 1 )(L')(N 3 )] (1) and [Co(L 2 )(L")(NCS)] (2) {where HL 1 = 2((2(piperidin-1-yl)ethylimino)methyl)-6-ethoxyphenol, HL 2 = 2-((3(dimethylamino)propylimino)methyl)-6-methoxyphenol, HL' = 1-acetyl-2-naphthol and HL" = 2,4-pentane-dione} have been synthesized and characterized by single crystal X-ray diffraction studies. Both complexes may be represented by a general formula: [Co(ABC)(DE)X], where ABC, DE and X represent tridentate, bidentate and monodentate ligands respectively. Both complexes are reactive towards the aerial oxidation of 3,5-di-tert-butylcatechol (3,5-DTBC) and oaminophenol (OAPH), and kinetics of the reactions are monitored spectrophotometrically. Analyses of the kinetic data reveal that complex 2 is better catalyst than complex 1 for both oxidation reactions. Tentative mechanistic implications of the catalytic oxidation reactions are also discussed. Mechanistic investigations of the catalytic behaviors indicate that the oxidation reactions proceed through catalyst-substrate intermediates. Results and discussion SynthesisThe Schiff base ligand, HL 1 , was synthesized by the 1:1 condensation of 1-(2-aminoethyl)piperidine with 3-ethoxysali-[a] K.

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“…To quantify the binding intensity of the complex with ct‐DNA, the intrinsic binding constant K b was calculated by monitoring the changes on its peak absorbance in the presence of DNA with increasing concentrations, using the following equation:…”

Section: Resultsmentioning

confidence: 99%

A New Samarium(III) Complex of Liriodenine: Synthesis, Crystal Structure, Antitumor Activity, and DNA Binding Study

Bao

Lai

Shen

et al. 2019

Zeitschrift anorg allge chemie

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A novel Sm III complex [Sm III (LA) 2 (pic) 3 ] (Hpic = picric acid), in which LA is a natural-derived alkaloid, liriodenine, was synthesized and characterized by IR, elemental analysis, and single-crystal X-ray diffraction analysis. This complex showed enhanced solubility compared with liriodenine and its metal complexes that have been previously reported. The interaction of the Sm III complex with ct-DNA was further investigated by various spectroscopic techniques, such as UV/Vis spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy (CD), and viscosity measurement. The results showed that the intrinsic binding constant K b of the Sm III complex with ct-DNA was calculated to be 5.03 ϫ 10 3 L·mol -1 by UV/Vis absorption spectral analysis. The thermodynamic fluorescent spectral analysis 570 suggested that the fluorescence intensity of the Sm III complex was weakened by ct-DNA mainly through a dynamic quenching mechanism. The presence of Sm complex could increase the viscosity of DNA solution, so it was concluded that the complex bound with ct-DNA via a moderate intercalative mode. Furthermore, this Sm III complex exhibited significant growth inhibition on the three typical tumor cell lines, HepG2, T-24, and SK-OV-3, with the corresponding IC 50 values, 10.76 Ϯ 0.19, 8.85 Ϯ 1.12, and 10.01 Ϯ 0.55 μM, respectively. The in vitro antitumor activity was comparable with LA and cisplatin, which suggested that it might be a new broad spectrum antitumor agent with more satisfying solubility. Scheme 1. Chemical structure of the natural alkaloid, liriodenine.

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Co(III) and Ni(II) complexes of an anthracene appended aroyl hydrazone: Synthesis, crystal structures, DNA binding and catecholase activity

Cited by 47 publications

References 69 publications

Ni(ii) and Co(ii) complexes of an asymmetrical aroylhydrazone: synthesis, molecular structures, DNA binding, protein interaction, radical scavenging and cytotoxic activity

Ni(ii) and Co(ii) complexes of an asymmetrical aroylhydrazone: synthesis, molecular structures, DNA binding, protein interaction, radical scavenging and cytotoxic activity

Two Cobalt(III) Schiff Base Complexes of the Type [Co(ABC)(DE)X]: Facile Synthesis, Characterization, Catechol Oxidase and Phenoxazinone Synthase Mimicking Activity

A New Samarium(III) Complex of Liriodenine: Synthesis, Crystal Structure, Antitumor Activity, and DNA Binding Study

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