Co(II) Complex of Quercetin–Spectral, Anti-/Pro-Oxidant and Cytotoxic Activity in HaCaT Cell Lines

Kalinowska, Monika; Lewandowska, Hanna; Pruszyński, Marek; Świderski, Grzegorz; Gołębiewska, Ewelina; Gryko, Kamila; Braun, Julia A.; Borkowska, Monika; Konieczna, Magda; Lewandowski, W.

doi:10.3390/app11199244

Cited by 6 publications

(5 citation statements)

References 45 publications

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“…However, at 100 µM, free Q exhibited higher antioxidant activity. Previous studies on Q-metal complexes with 2:1 Q-metal ratios suggest that the antioxidant activity of the complex might be metal ion dependent, similar to the lower antioxidant activities for Sb (II) and Tb (III) Q complexes [50,51] and the higher antioxidant activities for Co (II) and Pb (II) Q complexes [52][53][54]. The key difference of our samples from reported studies is the NP formation.…”

Section: Antioxidant Activity Of Qfenpsmentioning

confidence: 61%

Synthesis and Characterization of Quercetin–Iron Complex Nanoparticles for Overcoming Drug Resistance

et al. 2023

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Quercetin, one of the major natural flavonoids, has demonstrated great pharmacological potential as an antioxidant and in overcoming drug resistance. However, its low aqueous solubility and poor stability limit its potential applications. Previous studies suggest that the formation of quercetin-metal complexes could increase quercetin stability and biological activity. In this paper, we systematically investigated the formation of quercetin-iron complex nanoparticles by varying the ligand-to-metal ratios with the goal of increasing the aqueous solubility and stability of quercetin. It was found that quercetin-iron complex nanoparticles could be reproducibly synthesized with several ligand-to-iron ratios at room temperature. The UV-Vis spectra of the nanoparticles indicated that nanoparticle formation greatly increased the stability and solubility of quercetin. Compared to free quercetin, the quercetin-iron complex nanoparticles exhibited enhanced antioxidant activities and elongated effects. Our preliminary cellular evaluation suggests that these nanoparticles had minimal cytotoxicity and could effectively block the efflux pump of cells, indicating their potential for cancer treatment.

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Section: Antioxidant Activity Of Qfenpsmentioning

confidence: 61%

Synthesis and Characterization of Quercetin–Iron Complex Nanoparticles for Overcoming Drug Resistance

et al. 2023

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“…An essential step for the development of cobalt(II)-coordinated assembly is the study of the complex species that quercetin can form with the metal ion. For example, Bukhari et al [ 40 ] proposed a 2:1 (metal: ligand) complex in methanol, while Kalinowska et al [ 41 ] reported a 1:2 (metal: ligand) complex in Tris-HCl at pH 7.4. As the stoichiometry of quercetin complex species strongly depends on the experimental conditions, we decided to study the formation of Co(II)-Que complexes in buffered aqueous solution at pH 7.4 (MOPS 10 mM).…”

Section: Resultsmentioning

confidence: 99%

pH-Responsive Cobalt(II)-Coordinated Assembly Containing Quercetin for Antimicrobial Applications

Santonoceta

Sgarlata

2023

Molecules

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The development of novel drug delivery systems (DDSs) with promising antibacterial properties is essential for facing the emergency of increasing resistance to antimicrobial agents. The antibacterial features of quercetin and its metal complexes have been broadly investigated. However, several drawbacks affect their activity and effectiveness. In this work, we propose a DDS based on a pH-responsive cobalt(II)-coordinated assembly containing quercetin and polyacrylic acid. This system is suggested to trigger the release of the model drug in a pH-dependent mode by exploiting the localized acidic environment at the bacterial infection sites under anaerobic conditions. The delivery system has been designed by accurately examining the species and the multiple equilibria occurring in solution among the assembly components. The formation of cobalt(II) complexes with quercetin in the absence or presence of the pH-responsive polyacrylic acid was investigated in buffered aqueous solution at pH 7.4 using spectrophotometric (UV-Vis) and calorimetric (ITC) techniques. The determined binding affinities and thermodynamic parameters that resulted are essential for the development of a DDS with improved binding and release capabilities. Furthermore, the affinity of the polymer–cobalt(II) complex toward the model antimicrobial flavonoid was explored at the solid–liquid interface by quartz crystal microbalance (QCM-D) experiments, which provided marked evidence for drug loading and release under pH control.

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“…The role of LDs in cancer cells, particularly in relation to chemoresistance and cellular stress responses, is complex. The review by Petan et al (2023) highlights the interplay between lipid droplet metabolism and cancer cell viability, suggesting that dysregulated lipid droplet turnover may present novel therapeutic opportunities [13].…”

Section: Discussionmentioning

confidence: 99%

“…In scientific research, flavonoids, as molecules with pleiotropic activity on cancer cells, are being investigated as potential enhancers of the action of cytostatics [ 12 ]. Due to their very limited bioavailability, researchers are considering various strategies [ 13 ], such as modifying their structure, including the creation of metal complexes, encapsulation into nanoformulations as nanoparticles [ 12 , 14 ], and using them as synergistic or additive substances with conventional cytostatics [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Apigenin’s Modulation of Doxorubicin Efficacy in Breast Cancer

Golonko,

Olichwier,

Szklaruk

et al. 2024

Molecules

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Apigenin, a naturally derived flavonoid, is increasingly being acknowledged for its potential therapeutic applications, especially in oncology. This research explores apigenin’s capacity to modulate cancer cell viability, emphasizing its roles beyond its minimal antioxidant activity attributed to its basic molecular structure devoid of hydroxyl groups. We investigated apigenin’s effects on two breast cancer cell lines, estrogen-dependent MCF-7 and non-estrogen-dependent MDA-MB-231 cells. Our findings reveal that apigenin exerts a dose-dependent cytotoxic and anti-migratory impact on these cells. Interestingly, both apigenin and doxorubicin—a standard chemotherapeutic agent—induced lipid droplet accumulation in a dose-dependent manner in MDA-MB-231 cells. This phenomenon was absent in MCF-7 cells and not evident when doxorubicin and apigenin were used concurrently, suggesting distinct cellular responses to these treatments that imply that their synergistic effects might be mediated through mechanisms unrelated to lipid metabolism. A further chemoinformatics analysis indicated that apigenin and doxorubicin might interact primarily at the level of ATP-binding cassette (ABC) transporter proteins, with potential indirect influences from the AKT and MYC signaling pathways. These results highlight the importance of understanding the nuanced interactions between apigenin and conventional chemotherapeutic drugs, as they could lead to more effective strategies for cancer treatment. This study underscores apigenin’s potential as a modulator of cancer cell dynamics through mechanisms independent of its direct antioxidant effects, thereby contributing to the development of flavonoid-based adjunct therapies in cancer management.

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Co(II) Complex of Quercetin–Spectral, Anti-/Pro-Oxidant and Cytotoxic Activity in HaCaT Cell Lines

Cited by 6 publications

References 45 publications

Synthesis and Characterization of Quercetin–Iron Complex Nanoparticles for Overcoming Drug Resistance

Synthesis and Characterization of Quercetin–Iron Complex Nanoparticles for Overcoming Drug Resistance

pH-Responsive Cobalt(II)-Coordinated Assembly Containing Quercetin for Antimicrobial Applications

Apigenin’s Modulation of Doxorubicin Efficacy in Breast Cancer

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