The objective of this work was to design heat integrated, cost-effective and cleaner combined heat and power (CHP) generation plant from low cost 4 th generation biomass waste feedstocks. The novelty lies in the development of systematic site-wide heat recovery and integration strategies amongst biomass integrated gasification combined cycle processes so as to offset the low heating value of the biomass waste feedstocks. For the biomass waste based CHP plant technical and economic analysis, the process was based on low cost agricultural wastes like straws as the biomass feedstock and further established for a more predominant biomass feedstock, wood. The process was modeled using the ASPEN simulator. Three conceptual flowsheets were proposed, based on the integration of the flue gas from the char combustor, which was separately carried out from the steam gasification of biomass volatalised gases and tars, and carbon dioxide removal strategies. The cost of energy production included detailed levelised discounted cash flow analysis and was found to be strongly influenced by the cost of feedstock. Based on a combined energy generation of ~340-370 MW using straw wastes priced at 35.3 £/t or 40 Euro/t, with 8.5% and 8.61% by mass moisture and ash contents respectively, the cost of electricity generation was 4.59 p/kWh and 5.14 p/kWh for the cases without and with carbon capture respectively, with a 10% internal rate of return and 25 years of plant life. Based on the carbon capture value assigned by Carbon Credits Trading scheme, a much constrained viable price of 22 £/t of such agricultural waste feedstocks for CHP generation was obtained, while up to 60 £/t of waste feedstocks can be economically viable under the UK Climate Change Levy, respectively.