Co-expression of XIAP and CIAP1 Play Synergistic Effect on Patient’s Prognosis in Head and Neck Cancer

Yang, Xiaopei; Liu, Liu; Hu, Yan; Zhang, Ping; Hu, Qingang

doi:10.1007/s12253-018-0533-2

Cited by 8 publications

(5 citation statements)

References 27 publications

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“…In most studies, baseline biomarkers are evaluated for their prognostic role for disease outcomes (regardless of treatment), reflected by critical clinical trial endpoints. Key endpoints include overall survival (OS), progression‐free survival (PFS), disease‐free survival (DFS), loco‐regional (LR) control, and distant metastasis‐free survival …”

Section: Prognostic and Predictive Biomarkersmentioning

confidence: 99%

Review of emerging biomarkers in head and neck squamous cell carcinoma in the era of immunotherapy and targeted therapy

Hsieh

Wang

et al. 2019

Head & Neck

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Background Biomarkers in head and neck squamous cell carcinoma (HNSCC) emerge rapidly in recent years, especially for new targeted therapies and immunotherapies. Methods Recent, relevant peer‐reviewed evidence were critically reviewed and summarized. Results This review article briefly introduces essential biomarker concepts, including purposes and classifications (predictive, prognostic, and diagnostic markers), and the phases of biomarker development. We summarize current biomarkers in order of clinical utility; p16 and human papillomavirus status remain the most important and validated biomarkers in HNSCC. The rationale for biomarker study design continues to evolve with technological advances, especially whole‐exome or whole‐genomic sequencing. Noninvasive body fluid and liquid biopsy biomarkers appear to hold strong potential for development as tools for early cancer detection, cancer diagnosis, monitoring of disease recurrence, and outcome prediction. In light of discrepancies among different technologies, standardized approaches are needed. Conclusion Biomarkers from cancer tissue or blood in HNSCC could direct new anticancer therapies.

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Section: Prognostic and Predictive Biomarkersmentioning

confidence: 99%

Review of emerging biomarkers in head and neck squamous cell carcinoma in the era of immunotherapy and targeted therapy

Hsieh

Wang

et al. 2019

Head & Neck

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“…Previous studies concerning the relationship between the expression of XIAP and prognosis in solid cancers have shown convincing results 31,32 . Patients co‐expressing FOXM1, survivin, and nuclear XIAP had significantly worst OS in breast cancer 32 .…”

Section: Discussionmentioning

confidence: 91%

“…Previous studies concerning the relationship between the expression of XIAP and prognosis in solid cancers have shown convincing results. 31,32 Patients co-expressing FOXM1, survivin, and nuclear XIAP had significantly worst OS in breast cancer. 32 Especially, XIAP localized in nucleus, but not cytoplasm, is an independent prognostic factor in hormone receptor-negative breast cancer patients.…”

Section: Discussionmentioning

confidence: 97%

Combined inhibition of XIAP and autophagy induces apoptosis and differentiation in acute myeloid leukaemia

Huang

Zhou

Jiang

et al. 2023

J Cellular Molecular Medi

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“…The XIAPs regulate cell death signaling pathways through binding and inhibiting caspases and also participate in cancer initiation, promotion, and progression. [33][34][35][36]…”

Section: Potential Pathogenic Roles Of Gene Amplification In Mrtmentioning

confidence: 99%

Somatic Copy Number Alterations and Mutation Landscape in Before and Post-treatment Malignant Rhabdoid Tumor

Ma,

Kaushal,

Dehner

et al. 2024

J Clin Transl Pathol

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Co-expression of XIAP and CIAP1 Play Synergistic Effect on Patient’s Prognosis in Head and Neck Cancer

Cited by 8 publications

References 27 publications

Review of emerging biomarkers in head and neck squamous cell carcinoma in the era of immunotherapy and targeted therapy

Review of emerging biomarkers in head and neck squamous cell carcinoma in the era of immunotherapy and targeted therapy

Combined inhibition of XIAP and autophagy induces apoptosis and differentiation in acute myeloid leukaemia

Somatic Copy Number Alterations and Mutation Landscape in Before and Post-treatment Malignant Rhabdoid Tumor

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