Co-expression of TTF-1 and neuroendocrine markers in the human fetal lung and pulmonary neuroendocrine tumors

Mišković, Josip; Brekalo, Zdrinko; Vukojević, Katarina; Mišković, Helena Radić; Kraljevic, Daniela; Todorovic, Jelena; Šoljić, Violeta

doi:10.1016/j.acthis.2015.02.002

Cited by 13 publications

(13 citation statements)

References 62 publications

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“…27,28 The sensitivity and specificity of TTF-1 for the separation of pulmonary adenocarcinoma from squamous cell carcinomas are ~85% 17,29 and 97%, 29 respectively.…”

Section: Committee IVmentioning

confidence: 99%

Utilization of ancillary studies in the cytologic diagnosis of respiratory lesions: The papanicolaou society of cytopathology consensus recommendations for respiratory cytology

Layfield

Roy‐Chowdhuri

Baloch

et al. 2016

Diagnostic Cytopathology

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The Papanicolaou Society of Cytopathology has developed a set of guidelines for respiratory cytology including indications for sputum examination, bronchial washings and brushings, CT-guided FNA and endobronchial ultrasound guided fine needle aspiration (EBUS-FNA), as well as recommendations for classification and criteria, ancillary testing and post-cytologic diagnosis management and follow-up. All recommendation documents are based on the expertise of committee members, an extensive literature review, and feedback from presentations at national and international conferences. The guideline documents selectively present the results of these discussions. The present document summarizes recommendations for ancillary testing of cytologic samples. Ancillary testing including microbiologic, immunocytochemical, flow cytometric, and molecular testing, including next-generation sequencing are discussed.

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“…27,28 The sensitivity and specificity of TTF-1 for the separation of pulmonary adenocarcinoma from squamous cell carcinomas are ~85% 17,29 and 97%, 29 respectively.…”

Section: Committee IVmentioning

confidence: 99%

Utilization of ancillary studies in the cytologic diagnosis of respiratory lesions: The papanicolaou society of cytopathology consensus recommendations for respiratory cytology

Layfield

Roy‐Chowdhuri

Baloch

et al. 2016

Diagnostic Cytopathology

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“…CGA is a generally accepted NE cell marker that is expressed in NE cells during fetal development of several human tissues, e.g. pancreas or lung ( 25 , 26 ). The CGA-positive cells in fetal prostates are located in the epithelial compartment with proximity to nerve fibers, as typically described for prostatic NE cells.…”

Section: Resultsmentioning

confidence: 99%

Neuroendocrine Cells of the Prostate Derive from the Neural Crest

Szczyrba

Niesen

Wagner

et al. 2017

Journal of Biological Chemistry

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The histogenesis of prostatic neuroendocrine cells is controversial: a stem cell hypothesis with a urogenital sinus-derived progeny of all prostatic epithelial cells is opposed by a dual origin hypothesis, favoring the derivation of neuroendocrine cells from the neural crest, with the secretory and basal cells being of urogenital sinus origin. A computer-assisted 3D reconstruction was used to analyze the distribution of chromogranin A immunoreactive cells in serial sections of human fetal prostate specimens (gestation weeks 18 and 25). Immunohistochemical double labeling studies with YFP and serotonin antisera combined with electron microscopy were carried out on double-transgenic Wnt1-Cre/ROSA26-YFP mice showing stable YFP expression in all neural crest-derived cell populations despite loss of Wnt1 expression. 3D reconstruction of the distribution pattern of neuroendocrine cells in the human fetal prostate indicates a migration of paraganglionic cells passing the stroma and reaching the prostate ducts. Double-transgenic mice showed 55% double labeling of periurethral neuroendocrine cells expressing both serotonin and YFP, whereas single serotonin labeling was observed in 36% and exclusive YFP labeling in 9%. The results favor the assumption of a major fraction of neural crest-derived neuroendocrine cells in both the human and murine prostates.

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“…CDX2 expression is maintained in the adult small and large intestinal epithelia, and is upregulated in gastrointestinal pathological states (41). Furthermore, the co-expression of TTF-1 and neuroendocrine markers, including NCAM1, CgA and Syn, have contributed to the diagnosis of SCLC metastasis in the stomach (42).…”

Section: Discussionmentioning

confidence: 99%

Pathological diagnosis and treatment outcome of gastric metastases from small cell lung cancer: A case report

et al. 2019

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Small cell lung cancer (SCLC) is a type of lung cancer characterized by a rapid disease progression and poor prognosis. Its diagnosis is often accompanied by distant metastasis. A literature review revealed that metastases to the stomach from breast, lung and esophageal cancer are frequently reported. While SCLC is a common pathological subtype of lung cancer, literature on SCLC with gastric metastases is sporadic. The present study reviewed the literature using databases, including PubMed, WanFang Data and China National Knowledge Infrastructure, to analyze the clinicopathological features and outcome of patients with gastric metastases from SCLC. A total of 11 case reports and 6 retrospective studies comprising of 19 cases were compared and analyzed. In addition to the aforementioned studies, a case study describing a patient who survived for 10 months following a diagnosis of SCLC with gastric metastases is presented. The aim of the present study was to increase the understanding regarding the diagnosis and treatment of SCLC gastric metastasis.

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Co-expression of TTF-1 and neuroendocrine markers in the human fetal lung and pulmonary neuroendocrine tumors

Cited by 13 publications

References 62 publications

Utilization of ancillary studies in the cytologic diagnosis of respiratory lesions: The papanicolaou society of cytopathology consensus recommendations for respiratory cytology

Utilization of ancillary studies in the cytologic diagnosis of respiratory lesions: The papanicolaou society of cytopathology consensus recommendations for respiratory cytology

Neuroendocrine Cells of the Prostate Derive from the Neural Crest

Pathological diagnosis and treatment outcome of gastric metastases from small cell lung cancer: A case report

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