Co-expression of the aryl hydrocarbon receptor (AhR) and estrogen receptor (ER) in the developing teeth of rat offspring after rat mothers’ exposure to 2,3,7,8-tetrachlorodib

Kuropka, Piotr; Leśków, Anna; Herman, Katarzyna; Tarnowska, Małgorzata; Wiglusz, Rafał J.

doi:10.17219/acem/99613

Cited by 6 publications

(11 citation statements)

References 32 publications

(66 reference statements)

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“…These effects have been revealed in archaeological bone material. 50 Other studies showed that the use of a-tocopherol in high doses for a period of 3 weeks following the administration of TCDD contributed to a signicant reduction in IL-6 and TNF and also protected collagen against degradation. 3 The administration of ASA for a period of 3 weeks following the application of TCDD was aimed at reducing the inammatory reaction induced by the stimulation of COX-2.…”

Section: Discussionmentioning

confidence: 99%

“…The TCDD, a-tocopherol and ASA doses were determined based on previously published data. 50 Aer a period of 3 weeks following administration of TCDD in the individual groups (FTCDD, FTCDD + E, FTCDD + ASA), the above-mentioned groups and the FC group were mated with males that had not been treated with any chemicals. Aer a period of 7 days aer mating, pregnant females were placed in separate cages.…”

Section: Division Of Animalsmentioning

confidence: 99%

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Indirect study of the effect of α-tocopherol and acetylsalicylic acid on the mineral composition of bone tissue in the offspring of female rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: long-term observations

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Section: Division Of Animalsmentioning

confidence: 99%

Indirect study of the effect of α-tocopherol and acetylsalicylic acid on the mineral composition of bone tissue in the offspring of female rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: long-term observations

et al. 2019

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“…Several factors can disturb tooth formation [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. They include biological (genetic, developmental, viruses, bacteria, cancer), physical or chemical factors.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Selected Morphological, Physical and Chemical Parameters of the Teeth of the Offspring of Female Rats Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), Taking into Account the Protective Role of Selected Antioxidants—Preliminary Study

Nikodem

Klećkowska‐Nawrot

Goździewska‐Harłajczuk

et al. 2022

Animals

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The studies conducted so far indicate a negative effect of dioxins on the structure of the alveolar bone and teeth, especially in the developmental period in rats. The research aimed to analyze the indirect effect of dioxins contained in the body of female rats on the structure of the dental organ in their offspring in the neonatal period and to determine the possibility of reducing potential dioxin disorders of the structure of hard tissues in the offspring of intoxicated mothers by simultaneous administration of vitamin E or acetylsalicylic acid (ASA). Another goal of the research was to determine the level of magnesium, calcium and phosphorus contained in bone tissue as indicators of the mineralization process of hard tissues in rats, in the case of using 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and acetylsalicylic acid or α-tocopherol. The experiment was carried out on eight female rats of the Buffalo strain divided into four groups. From the offspring of eight females, the mandibles were removed from the mandibular joints, and then, after the removal of soft tissues, they were prepared for individual tests. Selected morphological, chemical and physical parameters of the teeth of the offspring of female rats from the experimental groups were analyzed. The analysis showed the effect of vitamin E and ASA on the content of Mg, Ca and P. In combination with TCDD, vitamin E and ASA, they positively inhibit the inflammatory process, preventing the leaching of Ca and Mg from the bones. ASA counteracted this phenomenon much more effectively than vitamin E. Detailed analysis of the tooth morphology showed that the molars’ crowns exhibit shape disturbances under the influence of TCDD. Individual nodules in teeth T1, T2, T3 did not fuse, and the roots showed signs of hypertrophy. The study confirmed the negative effect of TCDD on tooth development. Teeth arising early in development are the most sensitive to the disorders, while the later ones are less exposed to the toxic effects of TCDD transmitted by the mother.

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“…The liver plays a significant role in inflammatory response, directly affecting the synthesis of acute-phase proteins and the transformation of steroid hormones such as cortisol, estrogens, and testosterone [ 1 , 2 , 3 ]. It has been proven that there are many factors that affect the ultrastructure of hepatic cells, causing disorders of their secretory function which in turn affects the concentration of acute-phase proteins and the electrophoretic distribution of plasma proteins.…”

Section: Introductionmentioning

confidence: 99%

The Improvement of the Adaptation Process of Tocopherol and Acetylsalicylic Acid in Offspring of Mothers Exposed to TCDD

Madej

Leśków

Tarnowska

et al. 2021

Animals

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Dioxins are chemical compounds that may cause an inflammatory reaction. During dioxin-induced inflammation, generated reactive oxygen species lead to morphological changes in various tissues and in biochemical parameters. The aim of this study was to demonstrate the changes in the livers of rats whose mothers were exposed to dioxins and the protective role of α-tocopherol and acetylsalicylic acid in liver inflammation. The study material consisted of Buffalo rats who were the offspring of females treated with dioxin, dioxin + α-tocopherol, or dioxin + acetylsalicylic acid. Livers and blood samples were taken from the rats’ offspring, and then histopathological and biochemical analyses were performed. The histopathological analysis showed that the changes observed in the livers of neonates were the result of the dioxins derived from their mother. The biochemical analysis showed that the morphological changes in the liver affected its function, which manifested in a higher total protein concentration in the dioxin-treated group, and that the creatinine level in this group was significantly higher than that in the other groups. This effect was reduced by the protective role of α-tocopherol and acetylsalicylic acid. Based on these results, we came to the conclusion that dioxins significantly affect the structure of the liver, which negatively affects its function, mainly in the scope of the metabolism of plasma proteins and hepatic enzymes.

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Co-expression of the aryl hydrocarbon receptor (AhR) and estrogen receptor (ER) in the developing teeth of rat offspring after rat mothers’ exposure to 2,3,7,8-tetrachlorodib

Abstract: expression of the aryl hydrocarbon receptor and estrogen receptor in the developing teeth of rat offspring after rat mothers' exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and the protective action of α-tocopherol and acetylsalicylic acid.

Cited by 6 publications

References 32 publications

Indirect study of the effect of α-tocopherol and acetylsalicylic acid on the mineral composition of bone tissue in the offspring of female rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: long-term observations

Indirect study of the effect of α-tocopherol and acetylsalicylic acid on the mineral composition of bone tissue in the offspring of female rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: long-term observations

Assessment of Selected Morphological, Physical and Chemical Parameters of the Teeth of the Offspring of Female Rats Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), Taking into Account the Protective Role of Selected Antioxidants—Preliminary Study

The Improvement of the Adaptation Process of Tocopherol and Acetylsalicylic Acid in Offspring of Mothers Exposed to TCDD

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