Co-Expression of Bmi-1 and Podoplanin Predicts Overall Survival in Patients With Squamous Cell Carcinoma of the Head and Neck Treated With Radio(chemo)therapy

Vormittag, Laurenz; Thurnher, Dietmar; Geleff, Silvana; Pammer, Johannes; Heiduschka, Gregor; Brunner, Markus; Grasl, Matthäus Ch.; Erovic, Boban M.

doi:10.1016/j.ijrobp.2008.10.040

Cited by 66 publications

(53 citation statements)

References 28 publications

(31 reference statements)

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“…BMI-1 is expressed in the cells of healthy oral mucosa and also in tumor cells of various HNSCC [4,[6][7][8][9]13,14]. Previously both nuclear and cytoplasmic BMI-1 expressions have been scored [4,7,13].…”

Section: Discussionmentioning

confidence: 99%

“…In our study, we scored the samples only for nuclear staining, and used a cut-off of 50% for positive staining -a system previously used in our institution [14]. The cut-off points in other studies range from dichotomic positivevs-negative to 50% [6,9,14]. In this cohort the expression of BMI-1 was more prevalent in OPSCC than in OSCC and HPSCC.…”

Section: Discussionmentioning

confidence: 99%

“…Over-expression of BMI-1 has been shown in multiple malignant tumors, including nasopharyngeal and oral carcinomas [6,8]. In HNSCC, BMI-1 expression is linked with promotion of both tumor formation and invasion, as well as tumors metastatic capacity and increased resistance to ionizing radiation [6,7,9,10].…”

Section: Introductionmentioning

confidence: 99%

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Association of BMI-1 and p16 as prognostic factors for head and neck carcinomas

Lundberg

Renkonen

Haglund

et al. 2016

Acta Oto-Laryngologica

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A A 2016 , ' Association of BMI-1 and p16 as prognostic factors for head and neck carcinomas ' Acta Oto- Laryngologica , vol. 136 ,no. 5 , Conclusions BMI-1 is an upstream repressor of tumor suppressor p16 and their inverse expression patterns have been linked with patient survival in OPSCC. In this material only p16 remained a relevant prognostic marker in OPSCC. Objectives HNSCC tumors carry variable phenotypes and clinical outcomes depending on their anatomical location. In OPSCC, expression of tumor suppressor p16 is used as a surrogate marker of HPV infection and has prognostic value. There are no good prognostic biomarkers for HNSCC tumors of other anatomical locations. Aim To study the expression patterns of p16 and BMI-1 in not only oropharyngeal but also oral, hypopharyngeal, and laryngeal squamous cell carcinomas and to clarify their putative connections with clinical parameters, survival, and each other. Method Hospital records on 130 patients (59 OPSCC, 18 OSCC, 20 HPSCC, and 33 LSCC) diagnosed between 1997-2008 at the Helsinki University Hospital, Finland, were reviewed. BMI-1 and p16 expressions were studied by immunohistochemistry. Results Sixty-eight per cent of OPSCC expressed p16 and expression correlated with lower age, lower T-and higher N-category, and with improved OS and DFS. BMI-1 expression was most prevalent in OPSCC and LSCC, but had no clinical correlations. No correlation between p16 and BMI-1 expression was found.ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association of BMI-1 and p16 as prognostic factors for head and neck carcinomas

Lundberg

Renkonen

Haglund

et al. 2016

Acta Oto-Laryngologica

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“…In oral squamous cell carcinoma, the strong expression of podoplanin by malignant cells was associated with lymph node metastasis and poor clinical outcome. [5][6][7][8][9][10][11][12][13][14][15] A previous study has demonstrated that Chinese hamster ovary cells, which overexpress podoplanin, are retained in the lungs, suggesting that podoplanin plays a role in tumor metastasis because of its platelet aggregation-inducing activity. 16 The expression of podoplanin in normal and tumorous odontogenic cells is a recent topic of study.…”

Section: Introductionmentioning

confidence: 99%

Role of podoplanin expression in deciding the invasive potential of ameloblastoma – A retrospective IHC study

Ganvir

Khobragade

Bamane

et al. 2016

Journal of Oral Biology and Craniofacial Research

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“…BMI-1 has been demonstrated to be a key regulatory factor for the determination of a cellular phenotype in a variety of therapy-resistant cancers, including glioma (3)(4)(5)(6)(7)(8)(9). A previous study showed that BMI-1 levels increased in 79% of head and neck carcinoma patients, and a positive correlation was found between these BMI-1 levels and a lack of response to radiotherapy or chemotherapy (10). Abdouh et al (2009) reported that BMI-1 is expressed in glioblastoma tumors, is highly enriched in cluster of differentiation (CD)133 + tumor-initiating cells and is necessary for tumor cell growth (11).…”

Section: Introductionmentioning

confidence: 99%

Overexpression and lack of copy number variation in the BMI-1 gene in human glioma

et al. 2015

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Abstract. Malignant gliomas are neoplasms of the brain that are associated with a poor prognosis. The B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) gene is one of the major cancer stem cell factors responsible for treatment failure in glioma. In the present study, the DNA-RNA-protein alterations in the BMI-1 gene were assessed in 50 glioma samples. Copy number variations in the BMI-1 gene were analyzed using SYBR ® Green quantitative polymerase chain reaction. Gene expression analysis was performed using a Taqman assay and protein quantitation was performed using western blotting. A comparative Ct analysis showed the absence of copy number variations in all glioma samples. BMI-1 mRNA expression was found to be overexpressed in 36 out of 50 samples (72.0%), and 37 out of 50 samples showed overexpression (74.0%) of BMI-1 protein; this was statistically significant when compared with non-glioma tissues. It was observed that the protein and RNA expression in glioma were concordant. In this study on the BMI-1 gene, transcription and translation in glioma were observed and BMI-1 overexpression was found to be a common phenomenon.

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Co-Expression of Bmi-1 and Podoplanin Predicts Overall Survival in Patients With Squamous Cell Carcinoma of the Head and Neck Treated With Radio(chemo)therapy

Cited by 66 publications

References 28 publications

Association of BMI-1 and p16 as prognostic factors for head and neck carcinomas

Association of BMI-1 and p16 as prognostic factors for head and neck carcinomas

Role of podoplanin expression in deciding the invasive potential of ameloblastoma – A retrospective IHC study

Overexpression and lack of copy number variation in the BMI-1 gene in human glioma

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