2022
DOI: 10.3390/metabo12080708
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Co-Expression Network and Integrative Analysis of Metabolome and Transcriptome Uncovers Biological Pathways for Fertility in Beef Heifers

Abstract: Reproductive failure remains a significant challenge to the beef industry. The omics technologies have provided opportunities to improve reproductive efficiency. We used a multistaged analysis from blood profiles to integrate metabolome (plasma) and transcriptome (peripheral white blood cells) in beef heifers. We used untargeted metabolomics and RNA-Seq paired data from six AI-pregnant (AI-P) and six nonpregnant (NP) Angus-Simmental crossbred heifers at artificial insemination (AI). Based on network co-express… Show more

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Cited by 5 publications
(2 citation statements)
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“…Although many gene connections were identified in the P network, we found that SERPINE3 , FNDC1 , MRTFA , MEF2B , and ENSBTAG00000019474 were more connected in the NP network. Similar findings were reported by Banerjee et al [ 60 ]. Their study identified a rewiring of major gene regulators in the blood transcriptome network of NP crossbred heifers.…”
Section: Discussionsupporting
confidence: 92%
“…Although many gene connections were identified in the P network, we found that SERPINE3 , FNDC1 , MRTFA , MEF2B , and ENSBTAG00000019474 were more connected in the NP network. Similar findings were reported by Banerjee et al [ 60 ]. Their study identified a rewiring of major gene regulators in the blood transcriptome network of NP crossbred heifers.…”
Section: Discussionsupporting
confidence: 92%
“…And one of the genes associated with a region with TRD is the RELA gene that belongs to the subunits NF-κB . Regarding, PDGFB (platelet-derived growth factor) gene has reported that modulates the primordial to primary follicle transition, which is essential for female fertility [ 75 , 76 ].…”
Section: Discussionmentioning
confidence: 99%