Co-exposure of polystyrene microplastics and iron aggravates cognitive decline in aging mice via ferroptosis induction

Liu, Xiu; Yang, Hekai; Yan, Xinzhu; Xu, Shuang‐Feng; Fan, Yingcai; Xu, He; Ma, Yue; Hou, Wei; Javed, Rabia; Zhang, Yanhui

doi:10.1016/j.ecoenv.2022.113342

Cited by 38 publications

(7 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Once iron oxide interacts with the river water, the metal compounds precipitate out of the solution forming a bright yellow or orange sludge that colors the rocks and the riverbed, which was seen in small amounts in the water sampling process [39]. It should be noted that while iron in this analysis is within safe levels according to the US EPA guidelines, co-exposure of iron with microplastics could aggravate the cognitive impairment by disturbing brain iron homeostasis, and further inducing ferroptosis in cognitive-related brain areas [40]. This is particularly important since microplastics have recently been identified in Lackawanna River and in 52 other Pennsylvania waterways [5].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Examination of Cu, Pb, Zn, Fe, Mn and Cd in Lackawanna County Waters, Northeastern Pennsylvania: A Brief Report

2022

View full text Add to dashboard Cite

Lackawanna, a US county seat in Northeastern Pennsylvania has an estimated population of 216,000 in 2020. Over the years, it has been reported that several bodies of water found within the county have been contaminated with various metals. However, a comprehensive examination of the presence of these metals has not been conducted. The goal of this brief report was to perform a preliminary quantitative determination of the concentration of various metals found in Lackawanna County water sources. The sources analyzed included Lake Scranton, the Lackawanna River, the Griffin Reservoir, and Keyser Creek. Samples were taken from each source and analyses of copper, lead, zinc, iron, manganese, and cadmium using atomic absorption spectroscopy were performed. A copper concentration of 0.100 ppm was found in the Griffin Reservoir, and 0.380 ppm of iron was found in the Lackawanna River. The concentration of copper and iron in the Griffin Reservoir and Lackawanna River, respectively, were determined to be within safe levels according to guidelines set by the US Environmental Protection Agency.

show abstract

Section: Discussionmentioning

confidence: 99%

Comprehensive Examination of Cu, Pb, Zn, Fe, Mn and Cd in Lackawanna County Waters, Northeastern Pennsylvania: A Brief Report

2022

View full text Add to dashboard Cite

show abstract

“…Considering that MNPs often form an eco-corona in the environment, Liu et al investigated the coexposure of iron and MNPs and its impact on cognitive function in aged individuals. 91 Coexposure resulted in significant iron overload, elevated lipid peroxidation, inflammation, and processes associated with ferroptosis. Interestingly, these hazardous effects were absent in individual exposures.…”

Section: Volatile Organic Compounds (Vocs)mentioning

confidence: 99%

“…These findings suggest that MNPs could induce liver injury through ferroptosis. Considering that MNPs often form an eco-corona in the environment, Liu et al investigated the coexposure of iron and MNPs and its impact on cognitive function in aged individuals . Coexposure resulted in significant iron overload, elevated lipid peroxidation, inflammation, and processes associated with ferroptosis.…”

Section: Ferroptosis Inducers In Environmental Pollutantsmentioning

confidence: 99%

Ferroptosis Induced by Pollutants: An Emerging Mechanism in Environmental Toxicology

Yang,

Cai,

2024

Environ. Sci. Technol.

View full text Add to dashboard Cite

Environmental pollutants have been recognized for their ability to induce various adverse outcomes in both the environment and human health, including inflammation, apoptosis, necrosis, pyroptosis, and autophagy. Understanding these biological mechanisms has played a crucial role in risk assessment and management efforts. However, the recent identification of ferroptosis as a form of programmed cell death has emerged as a critical mechanism underlying pollutant-induced toxicity. Numerous studies have demonstrated that fine particulates, heavy metals, and organic substances can trigger ferroptosis, which is closely intertwined with lipid, iron, and amino acid metabolism. Given the growing evidence linking ferroptosis to severe diseases such as heart failure, chronic obstructive pulmonary disease, liver injury, Parkinson's disease, Alzheimer's disease, and cancer, it is imperative to investigate the role of pollutant-induced ferroptosis. In this review, we comprehensively analyze various pollutant-induced ferroptosis pathways and intricate signaling molecules and elucidate their integration into the driving and braking axes. Furthermore, we discuss the potential hazards associated with pollutant-induced ferroptosis in various organs and four representative animal models. Finally, we provide an outlook on future research directions and strategies aimed at preventing pollutant-induced ferroptosis. By enhancing our understanding of this novel form of cell death and developing effective preventive measures, we can mitigate the adverse effects of environmental pollutants and safeguard human and environmental health.

show abstract

“…Their combined neurotoxicity and oxidative damage exceed their individual effects [ 28 ]. The combined action of microplastics and iron promotes iron accumulation in the brain and aggravates iron death, thus causing serious damage to cognitive function [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Distribution of Micro-Nano PS, DEHP, and/or MEHP in Mice and Nerve Cell Models In Vitro after Exposure to Micro-Nano PS and DEHP

Han¹,

Yan²,

Li³

et al. 2023

Toxics

View full text Add to dashboard Cite

Polystyrene (PS) and di-(2-ethylhexyl) phthalate (DEHP) exist widely in the environment. However, their distribution in organisms remains unclear. We used three sizes (50 nm, 500 nm, and 5 μm) of PS and DEHP to study the distribution and accumulation of PS, DEHP, and mono(2-ethylhexyl) phthalate (MEHP) in mice and nerve cell models (HT22 and BV2 cells) and their potential toxicity. Results showed that PS entered the blood of mice, and the distribution of different particle sizes in different tissues was different. After the combined exposure to PS and DEHP, PS carried DEHP, which significantly increased the DEHP content and MEHP content and the highest content of MEHP was in the brain. With the decrease in PS particle size, the contents of PS, DEHP, and MEHP in the body increased. The levels of inflammatory factors were increased in the serum of the PS or/and DEHP group. In addition, 50 nm polystyrene can carry MEHP into nerve cells. These results suggest for the first time that PS and DEHP combined exposure can induce systemic inflammation, and the brain is an important target organ of PS and DEHP combined exposure. This study may serve as a reference for further evaluation of the neurotoxicity induced by combined exposure to PS and DEHP.

show abstract

Co-exposure of polystyrene microplastics and iron aggravates cognitive decline in aging mice via ferroptosis induction

Cited by 38 publications

References 63 publications

Comprehensive Examination of Cu, Pb, Zn, Fe, Mn and Cd in Lackawanna County Waters, Northeastern Pennsylvania: A Brief Report

Comprehensive Examination of Cu, Pb, Zn, Fe, Mn and Cd in Lackawanna County Waters, Northeastern Pennsylvania: A Brief Report

Ferroptosis Induced by Pollutants: An Emerging Mechanism in Environmental Toxicology

Distribution of Micro-Nano PS, DEHP, and/or MEHP in Mice and Nerve Cell Models In Vitro after Exposure to Micro-Nano PS and DEHP

Contact Info

Product

Resources

About