Co-exposure of neurotoxic contaminants (Pb and Mn) in drinking water of Zhob District, Baluchistan Pakistan

Chandio, Tasawar Ali; Khan, Muhammad Aqeel; Muhammad, Munira Taj; Yalcinkaya, Ozcan; Kayis, Ahmet Furkan

doi:10.1016/j.enmm.2020.100328

Cited by 8 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The blood–brain barrier (BBB) is composed of the choroid plexus and the brain capillary walls, which inhibit hazardous substance invasions and maintain brain homeostasis [ 3 ]. In the present study, the fish brain BBB permeability was detected by Evans blue dye (EBD) fluorescence after 28 d of exposure.…”

Section: Resultsmentioning

confidence: 99%

“…Heavy metal lead (Pb) is a toxic element to living beings, and it is present in various environments due to industrial Pb release, expired batteries, the use of Pb paint and fuel, etc. [ 1 , 2 , 3 ]. The World Health Organization (WHO) suggested that the safe standard of Pb in drinking water was less than 10 µg L −1 [ 4 ], which was adopted by the National Drinking Water Standards for Residents in China (GB5749-2006, China).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neurotoxicity of Chronic Co-Exposure of Lead and Ionic Liquid in Common Carp: Synergistic or Antagonistic?

Ding

Sultan

et al. 2022

IJMS

View full text Add to dashboard Cite

Previous studies have indicated that the harmful heavy metal lead (Pb) contamination in aquatic systems has caused intelligence development disorders and nervous system function abnormalities in juveniles due to the increased permeability of the blood–brain barrier. Ionic liquids (ILs) are considered “green” organic solvents that can replace traditional organic solvents. Studies have found the presence of ILs in soil and water due to chemical applications or unintentional leakage. Therefore, what would happen if Pb interacted with ILs in a body of water? Could ILs enable Pb to more easily cross the blood–brain barrier? Therefore, we examined the combined exposure of Pb and ILs in common carp at low concentration (18.3 mg L−1 of Pb(CH3COO)2•3 H2O and 11 mg L−1 of the IL 1-methyl-3-octylimidazolium chloride, 5% of their LC50) for 28 days in the present study. The result of a neurobehavioral assay showed that chronic exposure of lead at lower concentrations significantly altered fish movement and neurobehaviors, indicating that lead exposure caused neurotoxicity in the carp. Increases in the neurotransmitter dopamine levels and injuries in the fish brain accounted for neurobehavioral abnormalities induced by lead exposure. Moreover, we also found that lead could easily cross the blood–brain barrier and caused significant bioaccumulation in the brain. Particularly, our study indicated that the ionic liquid could not synergistically promote blood–brain barrier permeability and hence failed to increase the absorption of lead in the fish brain, suggesting that the combined exposure of lead and ILs was not a synergistic effect but antagonism to the neurotoxicity. The results of this study suggested that ILs could recede the Pb induced neurotoxicity in fish.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neurotoxicity of Chronic Co-Exposure of Lead and Ionic Liquid in Common Carp: Synergistic or Antagonistic?

Ding

Sultan

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…The Langmuir and Freundlich sorption isotherm models were used to predict the performance and mechanism of the sorption process on APM. The Langmuir isotherm model 49 indicates monolayer sorption on the homogeneous surface of the sorbent, and can be expressed as eqn (6):…”

Section: Sorption Modelsmentioning

confidence: 99%

“…5 Levels of about 0.01 ppm lead in wastewater and 0.1 ppm in agricultural soil have been recommended by the World Health Organization (WHO). 6,7 The direct or indirect intake of Pb 2+ through contaminated food, water, dust and aerosol particles in the air can induce carcinogenicity in humans and animals. 8 Even minor lead poisoning can reduce the growth, intellectual level and brain volume in children, and at a later stage, adults may become inattentive, irritable and hyperactive.…”

Section: Introductionmentioning

confidence: 99%