Co-existent Platelet Phagocytosis, Satellitism and Clumping Causing Spurious Thrombocytopenia

Paul, Preethi; Kaur, Manmeet; Kakkar, Naveen; Kumar, Nuthan

doi:10.1007/s12288-012-0160-0

Cited by 4 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here, we present an extremely rare case of PTCP results from platelet phagocytosis by neutrophils, platelet lack of granules and giant platelet. EDTA-dependent autoantibodies triggers several signaling pathways that activate platelets, leading to their aggregation, satellitism or phagocytosis [15,16].Platelet aggregation is the most common situation while platelet phagocytosis is the rarest one .Some studies suggest that platelet phagocytosis is related with EDTA-dependent autoantibodies, it usually occurs after platelet satellite phenomenon and is an extension of platelet satellite [4,17].In our case, we nd platelet phagocytosis by neutrophils, platelet lack of granules and giant platelet in the patient's peripheral blood smear(Fig. 1).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Platelet Phagocytosis by Neutrophils, Platelets Lack of Granules and Giant Platelets Result in Pseudothrombocytopenia

Zhu

Zhou

Li³

et al. 2021

Preprint

View full text Add to dashboard Cite

Pseudothrombocytopenia (PTCP) is a condition in which the decreased platelet count does not agree with the clinical status of the patient, can lead to misdiagnose, unnecessary tests, unnecessary treatment. The present case describes a 73-year-old man suffered with pulmonary tuberculosis, treated with anti-tuberculosis therapy (isoniazid, rifampicin, pyrazinamide, ethambutol, 2HRZE/4HR). One month later, the patient had a significant decrease in platelets (101 to 56 x109/L). Peripheral blood smear showed that 28% platelets were phagocytosis by neutrophils, 26% platelets were lack of granules and 6% platelets’ volume increased significantly. When the anticoagulant was changed from EDTA to sodium citrate, there was no change in the above phenomenon. By manual count, the value of platelets was 113 x 109/L. After the completion of anti-tuberculosis therapy, platelet morphology gradually returned to normal. HRZE treatment may cause platelet morphology abnormal, resulting in PTCP. In such cases, we should regularly review the peripheral blood smear to ensure the accuracy of the results and avoid unnecessary examination and treatment. The emergence of PTCP may does not mean the presence of specific disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The mechanism is not clearly de ned so far. Aggregation is the most common phenomenon while platelet phagocytosis is the rarest one in PTCP [4,5]. This little known in vitro phenomenon still under recognized may lead to misdiagnosis of thrombocytopenia, overtreatment, and further, even invasive, unnecessary testing.…”

Section: Introductionmentioning

confidence: 99%