Co-existence of pseudo-Chediak–Higashi anomaly and double minutes containing C-MYC oncogene in three patients with AML M2

Micronuclei‐associated MYC amplification in the form of double minute chromosomes in acute myeloid leukemia

“…On the other hand, pseudo-Chediak-Higashi granules, which are formed by fusion of azurophilic granules and show myeloperoxidase activity, are occasionally found in AML with or without dmin [6]. They were also detected in two of four AML cases with micronuclei and MYC amplification [2].…”

Multiple Pseudo-Chediak-Higashi Inclusions Associated with MYC Deletion in a Patient with Acute Myeloid Leukemia

“…Coexistence of PCH and MYC gene amplification in double-minute chromosomes has been previously reported in 3 patients with AML M2 [5]. The MYC oncogene has been shown to be amplified in several but not all cases of AML with double-minute chromosomes and has been associated with resistance and disease aggressiveness [10].…”

“…The pseudo-Chédiak-Higashi (PCH) anomaly is a large pink or purple cytoplasmic granule that has only been rarely described in acute myeloid leukemia (AML) [1,2,3,4,5,6,7,8,9]. These giant granules are azurophilic and myeloperoxidase positive.…”

“…Coexistence of this anomaly and MYC gene amplification in double-minute chromosomes have been reported in 3 patients with AML M2 [5]. On the other hand, in the revised literature, no reports have been found that describe the simultaneous PCH anomaly and MYC gene deletion.…”

Acute Myeloid Leukemia With Pseudo–Chédiak-Higashi Anomaly Exhibits a Specific Immunophenotype With CD2 Expression

“…Similar large pink or purple cytoplasmic granules, defined as pseudo-Chédiak-Higashi (PCH) anomaly, have been described in rare cases of acute myeloid leukemia (AML). [1][2][3][4][5] These giant granules are azurophilic and myeloperoxidase-positive. Electron microscopy demonstrated small vesicles in the cytoplasm near the giant granules, 6 suggesting the granules may be formed by the fusion of primary granules and/or the fusion of small, dense vesicles.…”