Co-existence of OSA and respiratory diseases and the influence of gender

Schiza, Sophia; Schwarz, Esther I.; Bonsignore, Maria R.; McNicholas, Walter T.; Pataka, Athanasia; Bouloukaki, Izolde

doi:10.1080/17476348.2024.2304065

Cited by 1 publication

(1 citation statement)

References 195 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cost of COPD management is dependent on the morbidity of the disease, which can be influenced by other comorbidities such as cardiovascular diseases (CVDs) and obstructive sleep apnea (OSA) [2]. COPD frequently coexists with OSA, which has significant clinical implications for these patients, as OSA has Life 2024, 14, 547 2 of 15 been linked to several potential consequences, including excessive daytime sleepiness, impaired daytime functioning, metabolic dysfunction, and an increased risk of cardiovascular disease and mortality [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Characteristics of Patients with Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease: Overlap Syndrome

Fanaridis,

Bouloukaki,

Stathakis

et al. 2024

Life

Self Cite

View full text Add to dashboard Cite

Overlap syndrome (OVS) is a distinct clinical entity that seems to result in potential cardiovascular consequences. We aimed to estimate the prevalence and risk factors for OVS in OSA patients and analyze clinical and PSG characteristics associated with OVS. In this cross-sectional study, 2616 patients evaluated for OSA underwent type-1 polysomnography (PSG). They were grouped as pure OSA (AHI > 15/h) and OVS patients. Demographics, PSG data, pulmonary function tests and arterial blood gases (ABGs) were compared between groups after adjustments for confounders. OSA was diagnosed in 2108 out of 2616 patients. Of those, 398 (19%) had OVS. Independent predictors of OVS were older age [OR: 5.386 (4.153–6.987)], current/former smoking [OR: 11.577 (7.232–18.532)], BMI [OR: 2.901 (2.082–4.044)] and ABG measurements [PaCO2 ≥ 45 OR: 4.648 (3.078–7.019), PO2 [OR: 0.934 (0.920–0.949)], HCO3− [OR: 1.196 (1.133–1.263), all p < 0.001]. OVS was also associated with prevalent hypertension [OR: 1.345 (1.030–1.758), p = 0.03] and cardiovascular disease [OR: 1.617 (1.229–2.126), p < 0.001], depressive symptoms [OR: 1.741 (1.230–2.465), p = 0.002] and nocturia [OR: 1.944 (1.378–2.742), p < 0.001], as well as with indices of OSA severity. Disturbances in sleep architecture were more prominent in OVS expressed by lower %N3 and REM% and higher arousal index. Our data suggest that OVS is prevalent among OSA patients, with distinct clinical and PSG characteristics. These characteristics could be utilized as predictive factors for early identification and further evaluation of these patients towards desirable patient-reported outcomes.

show abstract