Co-existence of hematological disease in cardiac patients presented with chest pain

Abstract

Introduction The important association between hematological disorders and cardiovascular system originates within multiple points of interface, ranging from heart and its structural constituents, coronary arteries and veins, cerebrovascular, pulmonary and peripheral vasculature. Any anomaly of either of the blood components can severely affect the blood flow and blood viscosity which finally leads to thrombosis. Objective This study will help clinicians to evaluate those patients having hematological abnormality and are having potential prothrombotic state due to abnormal hemostasis. Rationale Introducing cardiac health screening in patients with any hematological disease can improve the quality of life of these patients. Material and methods This cross sectional analytical study was conducted in hematology Department of Peshawar institute of Cardiology after approval from hospital ethical and research committee. Study duration was 6 months. All patients were subjected to detailed history, clinical examination. Demographic (Age, Gender) and relevant clinical information. Investigation like CBC, coagulation profile, hemolytic profile, Chest X-ray, ECG, Echo, Angiography findings were used to monitor patient’s clinical status. Results Out of 43 patients, 08 cases (18.60%) presented were of benign hematological disorder and the rest 35 cases (81.40%) presented with malignant hematological disorders. A significant P- value of (0.000) was observed in patients with malignant hematological disorder in association with benign hematological disorders. Conclusion From our study findings, several local and international platforms data, it can be concluded that those hematological abnormalities which have direct or indirect association with thromboembolic events can present with cardiac manifestation in the form of chest pain or acute myocardial injury at any stage of disease process. Therefore, clinicians must evaluate patients having hematological abnormality and are having potential prothrombotic state due to abnormal hemostasis for cardiac manifestation of the disease as well.