Co-Essentiality Analysis Identifies PRR12 as a Regulator of Cohesin and Genome Integrity
Alexandra L. Nguyen,
Eric Smith,
Iain M. Cheeseman
Abstract:The cohesin complex is critical for genome regulation, relying on specialized co-factors to mediate its diverse functional activities. Here, by analyzing patterns of similar gene requirements across cell lines, we identify PRR12 as a regulator of cohesin and genome integrity. We show that PRR12 interacts with cohesin and PRR12 loss results in a reduction of nuclear-localized cohesin and an accumulation of DNA lesions. We find that different cell lines across human and mouse exhibit significant variation in the… Show more
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