Co-endemicity of Plasmodium falciparum and Intestinal Helminths Infection in School Age Children in Rural Communities of Kwara State Nigeria

Adedoja, Ayodele; Tijani, Bukola Deborah; Akanbi, AA; Ojurongbe, Taiwo Adetola; Adeyeba, Oluwaseyi Adegboyega; Ojurongbe, Olusola

doi:10.1371/journal.pntd.0003940

Cited by 28 publications

(34 citation statements)

References 35 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…heamatobium have equal chances of being infected with P . falciparum as children with no worm infection [ 45 ], while Ateba and collaborators found a significant increase of plasmodium asexual parasite prevalence among Schistosoma infected children in comparison to the uninfected [ 9 ]. Conflicting results found in the literature on schistosomiasis-malaria co-infection issue suggest that there are potential confounding factors not yet established which need to be taken into account.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Schistosoma haematobium effects on Plasmodium falciparum infection modified by soil-transmitted helminths in school-age children living in rural areas of Gabon

et al. 2018

View full text Add to dashboard Cite

BackgroundMalaria burden remains high in the sub-Saharan region where helminths are prevalent and where children are often infected with both types of parasites. Although the effect of helminths on malaria infection is evident, the impact of these co-infections is not clearly elucidated yet and the scarce findings are conflicting. In this study, we investigated the effect of schistosomiasis, considering soil-transmitted helminths (STH), on prevalence and incidence of Plasmodium falciparum infection.MethodologyThis longitudinal survey was conducted in school-age children living in two rural communities in the vicinity of Lambaréné, Gabon. Thick blood smear light microscopy, urine filtration and the Kato-Katz technique were performed to detect malaria parasites, S. haematobium eggs and, STH eggs, respectively. P. falciparum carriage was assessed at inclusion, and incidence of malaria and time to the first malaria event were recorded in correlation with Schistosoma carriage status. Stratified multivariate analysis using generalized linear model was used to assess the risk of plasmodium infection considering interaction with STH, and survival analysis to assess time to malaria.Main findingsThe overall prevalence on subject enrolment was 30%, 23% and 9% for S. haematobium, P. falciparum infections and co-infection with both parasites, respectively. Our results showed that schistosomiasis in children tends to increase the risk of plasmodium infection but a combined effect with Trichuris trichiura or hookworm infection clearly increase the risk (aOR = 3.9 [95%CI: 1.7–9.2]). The incidence of malaria over time was 0.51[95%CI: 0.45–0.57] per person-year and was higher in the Schistosoma-infected group compared to the non-infected group (0.61 vs 0.43, p = 0.02), with a significant delay of time-to first-malaria event only in children aged from 6 to 10-years-old infected with Schistosoma haematobium.ConclusionsOur results suggest that STH enhance the risk for P. falciparum infection in schistosomiasis-positive children, and when infected, that schistosomiasis enhances susceptibility to developing malaria in young children but not in older children.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Some authors have previously shown that T . trichiura [ 18 ] and hookworm [ 45 , 46 ] individually can affect the association between schistosomiasis and malaria co-infection by increasing the risk of being infected with P . falciparum parasites.…”

Section: Discussionmentioning

confidence: 99%

Schistosoma haematobium effects on Plasmodium falciparum infection modified by soil-transmitted helminths in school-age children living in rural areas of Gabon

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Of 309 Nigerian children from our previous study [15], 76 were asymptomatically infected with P. falciparum, 94 were infected with S. haematobium and 62 were coinfected with both parasites. The mean age of children asymptomatically infected with P. falciparum, S. haematobium or with both P. falciparum and S. haematobium was 9.6, 9.9 and 9.7 years, respectively.…”

Section: Characteristics Of the Study Groupmentioning

confidence: 99%

Differential contribution of interleukin‐10 promoter variants in malaria and schistosomiasis mono‐ and co‐infections among Nigerian children

Adedoja

Hoàn

Tong

et al. 2017

Tropical Med Int Health

Self Cite

View full text Add to dashboard Cite

Abstractobjective Interleukin-10 (IL-10) is an anti-inflammatory cytokine produced by Th1 cells and macrophages. The rationale of this study was to examine and validate possible contributions of IL-10 promoter polymorphisms in sub-Saharan Africa in children infected with either Plasmodium falciparum or Schistosoma haematobium and in children co-infected with both parasites.materials and methods A total of 309 Nigerian children aged 4-15 years were recruited. The study group consisted of individuals infected either with P. falciparum (n = 76) or S. haematobium (n = 94) in mono-infections, a group of children co-infected with both P. falciparum and S. haematobium (n = 62) and matched healthy controls (n = 77). The IL-10 promoter polymorphisms -1082G/A, -819C/T and -592C/A were genotyped by direct sequencing.results The frequencies of the IL-10 -1082GG genotype, the -1082G allele and haplotype GCC (positions -1082, -819 and -592) were higher in children infected with P. falciparum than in healthy controls, indicating that the -1082GG genotype and the -1082G allele and the GCC haplotype are associated with increased susceptibility to malaria infection (OR = 3.4, 95% CI = 1.2-10.8, P = 0.02; OR = 2.5, 95% CI = 1.1-3.4, P = 0.02; OR = 3.8, 95% CI = 2.0-7.2, P = 0.0001, respectively). Children with the -1082GG genotype had a higher parasitaemia than children with the -1082AA or -1082AG genotypes (P = 0.0017). Haplotype GCC occurred more frequently in children infected with S. haematobium, while haplotype GTA was less frequent than in controls (OR = 2.2, 95% CI = 1.2-4.4, P = 0.017 and OR = 0.1, 95% CI = 0.02-0.5, P = 0.0004, respectively). No differences in the frequencies of IL-10 promoter polymorphisms were observed between children with P. falciparum-S. haematobium co-infections and healthy controls.conclusion Although IL-10 promoter polymorphisms are not associated with P. falciparum and S. haematobium co-infection, variant -1082G/A and haplotype GCC are associated with malaria, whereas the IL-10 haplotypes GCC and GTA are associated with schistosomiasis.

show abstract

“…This however, is more of a problem in resource limited countries like Nigeria where poor hygiene and sanitation, indiscriminate defecation by scavenging animals and humans as well as the use of unclean water for irrigation of fruits and vegetables are common. For instance, helminths including Hymenolepis nana, Toxocara canis, Ascaris lumbricoides, Ancylostoma duodenale and Enterobius vermicularis which are transmissible through the consumption of raw vegetables are well documented in humans in Nigeria [27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Parasites of importance for human health on edible fruits and vegetables in Nigeria: a systematic review and meta-analysis of published data

Karshima

2018

Pathogens and Global Health

View full text Add to dashboard Cite

Contamination of edible fruits and vegetables is now a global public health issue despite their health benefits as non-pharmacological prophylaxis against chronic diseases. Studies that will harness the extent of parasitic contaminations will ensure public health protection. Here, the prevalence and distribution of parasites of importance for human health on fruits and vegetables in Nigeria were determined through a systematic review and meta-analysis of published data. The random-effects model was used to determine pooled prevalence estimate (PPE). Heterogeneity was evaluated by the Cochran's Q-test. Parasites overall PPE of 32.4% (95% CI: 0.73, 0.91) was observed from 19 eligible studies reported across 13 Nigerian states. Sub-groups PPEs ranged between 3.5% (95% CI: 0.45, 1.86) and 58.5% (95% CI: 1.40, 4.09). A high degree of heterogeneity 97.53% (95% CI: 0.30, 0.46, P: 0.000) was observed within studies and sub-groups. Cryptosporidium species were the most prevalent, while Ancylostoma duodenale and Ascaris lumbricoides had the widest geographical distribution. Pineapple (Prev: 41.3%, 95% CI: 0.40, 0.75) and lettuce (Prev: 51.5%, 95% CI: 0.37, 0.68) recorded the highest level of parasitic contamination. Parasites of importance for human health are prevalent on edible fruits and vegetables in Nigeria. Prevalence estimates were highest in the South-eastern region and during the most recent decade. Adequate washing of fruits and vegetables, on-farm irrigation of vegetables using good sources of water and adequate hygiene by food handlers will help the general public to maximize the health benefits associated with the intake of fruits and vegetables while minimizing the risk of acquiring parasitic infections.

show abstract

Co-endemicity of Plasmodium falciparum and Intestinal Helminths Infection in School Age Children in Rural Communities of Kwara State Nigeria

Cited by 28 publications

References 35 publications

Schistosoma haematobium effects on Plasmodium falciparum infection modified by soil-transmitted helminths in school-age children living in rural areas of Gabon

Schistosoma haematobium effects on Plasmodium falciparum infection modified by soil-transmitted helminths in school-age children living in rural areas of Gabon

Differential contribution of interleukin‐10 promoter variants in malaria and schistosomiasis mono‐ and co‐infections among Nigerian children

Parasites of importance for human health on edible fruits and vegetables in Nigeria: a systematic review and meta-analysis of published data

Contact Info

Product

Resources

About