Co-encapsulation of retinoic acid, curcumin and resveratrol by spray-drying of alginic acid sodium-based emulsions and ethyl cellulose-based solutions: Impact on the co-delivery profiles

Gonçalves, Antónia; Rocha, Fernando; Estevinho, Berta N.

doi:10.1016/j.ijbiomac.2022.10.207

Cited by 12 publications

(7 citation statements)

References 50 publications

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“…The values of the parameter τ d obtained directly from the experimental vitamin release profiles are very similar to the parameter τ d obtained from the model for all the types of vitamin microstructures. In relation to the parameter β, according to the value of the β (shape parameter of the curve), different conclusions can be obtained: if β = 1 the shape of the curve corresponds exactly to an exponential profile; if β > 1, the shape of the curve becomes sigmoidal with a turning point; and if β < 1, the shape of the curve would show a steeper increase than the one with β = 1 57,58 . For all samples the parameter β was <1.…”

Section: Resultsmentioning

confidence: 90%

“…In relation to the parameter ⊎, according to the value of the ⊎ (shape parameter of the curve), different conclusions can be obtained: if ⊎ = 1 the shape of the curve corresponds exactly to an exponential profile; if ⊎ > 1, the shape of the curve becomes sigmoidal with a turning point; and if ⊎ < 1, the shape of the curve would show a steeper increase than the one with ⊎ = 1. 57,58 For all samples the parameter ⊎ was <1.…”

Section: Resultsmentioning

confidence: 99%

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Electrosprayed B‐complex vitamins/zein microparticles for drug sustained release and antioxidant applications

Coelho,

Giron,

Rocha

et al. 2023

J of Chemical Tech & Biotech

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B‐complex vitamins are important compounds for the human body, namely for brain and cell function and preventing infections and diseases. However, the instability associated to these vitamins is a critical problem. Their encapsulation into delivery systems that are able to protect them against undesirable conditions can be one solution. The present study focuses on the encapsulation of the B‐complex vitamin at different concentrations (1, 5 and 10% w/w) by an electrohydrodynamic technique. The synergistic effect of the vitamins B in the enhancing antioxidant activity of the microstructures is investigated. Zein, a prolamine protein found in corn, was the chosen wall material. The matrices were analysed in terms of the surface morphology, encapsulation efficiency, antioxidant activity and release of the B‐vitamins from the zein microstructures. Spherical microbeads were produced with size between 0.32 and 0.38 μm and with high efficiency of encapsulation. Vitamins release profiles were obtained and the results suggested similar release profiles (in the range of 10 ‐ 40 hours) for the vitamin B3, vitamin B6, B3 plus B6 and B3 plus B6 plus B9. The Weibull model was used to adjust the experimental release profiles. Regarding the assessed antioxidant activity, it was possible to visualize an activity enhancement of the vitamin B3, vitamin B9, combined vitamins B6 and B9. Overall, the proposed encapsulation microsystems are a suitable alternative for the encapsulation of sensitive bioactive ingredients, such as vitamins, against external conditions, maintaining the indispensable stability essential for food, nutraceutical and pharmaceutical products.This article is protected by copyright. All rights reserved.

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Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Electrosprayed B‐complex vitamins/zein microparticles for drug sustained release and antioxidant applications

Coelho,

Giron,

Rocha

et al. 2023

J of Chemical Tech & Biotech

Self Cite

View full text Add to dashboard Cite

show abstract

“…The encapsulation efficiency (%) was determined by the ratio between the mass of each bioactive compound present in the microparticles and the mass of each bioactive compound used to prepare the solution fed to the spray-dryer (Equation (2)), considering the production yield [ 25 ]. The loading capacity (%) was determined by the ratio between the mass of each bioactive compound and the mass of microparticles (Equation (3)).…”

Section: Methodsmentioning

confidence: 99%

Development and Characterization of Microparticles with Actinidia arguta Leaves Extract by Spray-Drying: A New Mind-Set Regarding Healthy Compounds for Oral Mucositis

et al. 2023

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Actinidia arguta leaves have gained notoriety over the past years due to their rich bioactive composition with human pro-healthy effects, particularly in relation to antioxidants. Nevertheless, antioxidants are well known for their chemical instability, making it necessary to develop suitable delivery systems, such as microparticles, to provide protection and ensure a controlled release. The aim of this work was to produce polymeric particles of A. arguta leaves extract by spray-drying that may improve the oral mucositis condition. Microparticles were characterized by size, shape, antioxidant/antiradical activities, swelling capacity, moisture content, and effect on oral cells (TR146 and HSC-3) viability, with the aim to assess their potential application in this oral condition. The results attested the microparticles’ spherical morphology and production yields of 41.43% and 36.40%, respectively, for empty and A. arguta leaves extract microparticles. The A. arguta leaves extract microparticles obtained the highest phenolic content (19.29 mg GAE/g) and antioxidant/antiradical activities (FRAP = 81.72 µmol FSE/g; DPPH = 4.90 mg TE/g), being perceived as an increase in moisture content and swelling capacity. No differences were observed between empty and loaded microparticles through FTIR analysis. Furthermore, the exposure to HSC-3 and TR146 did not lead to a viability decrease, attesting their safety for oral administration. Overall, these results highlight the significant potential of A. arguta leaves extract microparticles for applications in the pharmaceutical and nutraceutical industries.

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“…Several physico-chemical factors might be influenced by the biocompounds' characteristics when they are developed into the microstructures. There are several techniques that could be used to verify and characterize the systems [106,107]. Some examples are the following:…”

Section: Relevant Physico-chemical Analysis Of Microstructures Contai...mentioning

confidence: 99%

A Brief Review on the Electrohydrodynamic Techniques Used to Build Antioxidant Delivery Systems from Natural Sources

Coelho

Estevinho

2023

Molecules

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Extracts from plants have been one of the main sources of antioxidants, namely polyphenols. The associated drawbacks, such as instability against environmental factors, low bioavailability, and loss of activity, must be considered during microencapsulation for a better application. Electrohydrodynamic processes have been investigated as promising tools to fabricate crucial vectors to minimize these limitations. The developed microstructures present high potential to encapsulate active compounds and for controlling their release. The fabricated electrospun/electrosprayed structures present different benefits when compared with structures developed by other techniques; they present a high surface-area-to-volume ratio as well as porosity, great materials handling, and scalable production—among other advantages—which make them able to be widely applied in different fields, namely in the food industry. This review presents a summary of the electrohydrodynamic processes, main studies, and their application.

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Co-encapsulation of retinoic acid, curcumin and resveratrol by spray-drying of alginic acid sodium-based emulsions and ethyl cellulose-based solutions: Impact on the co-delivery profiles

Cited by 12 publications

References 50 publications

Electrosprayed B‐complex vitamins/zein microparticles for drug sustained release and antioxidant applications

Electrosprayed B‐complex vitamins/zein microparticles for drug sustained release and antioxidant applications

Development and Characterization of Microparticles with Actinidia arguta Leaves Extract by Spray-Drying: A New Mind-Set Regarding Healthy Compounds for Oral Mucositis

A Brief Review on the Electrohydrodynamic Techniques Used to Build Antioxidant Delivery Systems from Natural Sources

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