Co-encapsulation of resveratrol and curcumin in lipid-core nanocapsules improves their in vitro antioxidant effects

Coradini, Karine; Lima, Fernanda O.; Oliveira, Carlos Marcos Barcellos de; Chaves, Paula dos Santos; Athayde, Margareth Linde; Carvalho, Leandro Machado de; Beck, Ruy Carlos Ruver

doi:10.1016/j.ejpb.2014.04.009

Cited by 175 publications

(92 citation statements)

References 47 publications

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“…As evident from the figure, the in vitro release behavior was comparable for both drugs, in which the cumulative percentage of drug released was statistically insignificant at almost all time points (p40.05). This may be attributed to the close log D value of both drugs, being 3.1 for resveratrol and 2.9 for curcumin (Coradini et al, 2014). After 6 h, approximately 60% of both drugs were released from the formula following a diffusion-controlled mechanism.…”

Section: Dpph Antioxidant Assaymentioning

confidence: 92%

“…The small nanometer size with the relative monodispersity of the nanoemulsion particles (PDI less than 0.4) is considered advantageous. Coradini et al (2014) reported that co-encapsulation of the two polyphenols curcumin and resveratrol in lipid core nanocapsules at a concentration of 1 mg/ml produced micrometer-sized particles demonstrating the higher solubilizing capacity of the prepared nanoemulsions.…”

Section: Measurement Of Particle Size and Zeta Potential Of Nanoemulsmentioning

confidence: 99%

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Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

Nasr

2015

Drug Delivery

164

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RESEARCH ARTICLEDevelopment of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery Maha NasrDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt AbstractThe development of mucoadhesive lipidic nanoemulsion based on hyaluronic acid, co-encapsulating two polyphenols (resveratrol and curcumin) for the transnasal treatment of neurodegenerative diseases was attempted in the current manuscript. Nanoemulsions were prepared by the spontaneous emulsification method, and were characterized for their particle size, zeta potential, mucoadhesive strength and morphology. The selected formula was tested for its antioxidant potential, in vitro and ex vivo release of the two polyphenols, safety on nasal mucosa and in vivo quantification of the two drugs in rat brains. Its stability was tested by monitoring the change in particle size, zeta potential, drugs' content and antioxidant potential upon storage for 3 months. The optimized hyaluronic acid based nanoemulsion formula displayed a particle size of 115.2 ± 0.15 and a zeta potential of À23.9 ± 1.7. The formula displayed a spherical morphology and significantly higher mucoadhesive strength compared to its non mucoadhesive counterpart. In addition, the nanoemulsion was able to preserve the antioxidant ability of the two polyphenols and protect them from degradation. Diffusion controlled release of the two drugs was achievable till 6 hours, with an ex vivo flux across sheep nasal mucosa of 2.86 and 2.09 mg/cm 2 hr for resveratrol and curcumin, respectively. Moreover, the mucoadhesive nanoemulsion was safe on nasal mucosa and managed to increase the amounts of the two polypehnols in the brain (about 7 and 9 folds increase in AUC 0-7 h for resveratrol and curcumin, respectively). Hyaluronic acid based lipidic nanoemulsion proved itself as a successful carrier enhancing the solubility, stability and brain targetability of polyphenols.

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Section: Dpph Antioxidant Assaymentioning

confidence: 92%

Section: Measurement Of Particle Size and Zeta Potential Of Nanoemulsmentioning

confidence: 99%

Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

Nasr

2015

Drug Delivery

164

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“…In order to discover the physical stability change of liposomes as soon as possible, Turbiscan Lab Õ Expert was used to determine the stability of PTX-TSL. This method can detect the negligible variation by transmission or backscattering profiles before other instability phenomena emerge, thus shorting the lapse of time necessary for the identification of instability (Coradini et al, 2014). Variation over 10% in the graphical profiles of backscattering or transmission is deemed as the signal of instability (Marianecci et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Preparation, characterization, and efficacy of thermosensitive liposomes containing paclitaxel

Wang¹,

Zhang²,

Yang³

et al. 2015

Drug Delivery

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To increase the anti-tumor activity of paclitaxel (PTX), novel temperature-sensitive liposomes loading paclitaxel (PTX-TSL) were developed. In vitro, characteristics of PTX-TSL were evaluated. The mean particle diameter was about 100 nm, and the entrapment efficiency was larger than 95%. The phase-transition temperature of PTX-TSL determined by differential scanning calorimetry was about 42C. The result of in vitro drug release from PTX-TSL illustrated that release rate at 37 C was obviously lower than that at 42 C. Stability data indicated that the liposome was physically and chemically stable for at least 3 months at À20 C. In vivo study, after three injections with hyperthermia in the xenograft lung tumor model, PTX-TSL showed distinguished tumor growth suppression, compared with non-temperature-sensitive liposome and free drug. The results of intratumoral drug concentration indicated that PTX-TSL combined with hyperthermia delivered more paxlitaxel into the tumor location than the other two paxlitaxel formulations. In summary, PTX-TSL combined with hyperthermia significantly inhibited tumor growth, due to the increased targeting efficiency of PTX to tumor tissues. Such approach may enhance the delivery efficiency of chemotherapeutics into solid tumors.

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“…DN is most common complication of diabetes mellitus and is characterized by pathologically by proteinuria, fibrosis, podocyte injury, extracellular matrix expansion, thickening of basement membrane and biochemically raised level of uric acid, serum urea and serum creatinine level and radiological finding on USG is small kidney and oxidative stress plays major role in pathogenesis. [1][2] Ideal Nanocarriers [1] : Nanocarriers should be capable of safely and expeditiously transporting siRNA to the target organ or tissue.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Nanoparticles for Delivering Drugs and Silencing Multiple Genes or Gene activation in Diabetic Nephropathy

Soni¹

2017

IJLSSR

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ABSTRACT-Dialysis is the only mode of available palliative therapeutic modality to patient with end stage of renal disease. Diabetes is one of the foremost common causes of chronic renal disease and affecting large number of diabetic patients. By many theory, hypothesis and study are carried to understand the pathogenesis of Diabetic kidney disease or complication of diabetes i.e. diabetic nephropathy (DN) and based on pathophysiology many drugs and molecules are being developed targeting enzymes, intracellular proteins, micro RNA, Receptor, channel etc. Genes (like NFE2L2, HD1, RPD3 etc.) responsible for synthesis of transcription factor, proteins, enzymes and cytokine factors, intracellular antioxidant factor all play vital role in pathophysiology of DN. Targeting multiple genes, which play important role in pathophysiology of DN with nanoparticle loaded with siRNA or drugs or combination will not only reduce multiple drug and medication burden but also mitigate the disease faster and with reversal of pathological changes with safety, if the challenges are met. It is possible to target multiple genes, which play vital role in fibrosis and extracellular matrix expansion which are key features of DN with biodegradable particle. Each drug by unique mechanism specifically targeting protein, enzymes, receptor, channel etc. mitigates the progress of DN and multiple drugs are needed to inhibit the various mechanism. The approach of silencing the multiple genes or delivering drugs inside the cell organelles with biodegradable nanoparticles is novel, versatile and target specific to inhibit the progress of DN and to reverse the pathological changes efficiently as compared to drugs/molecules, if challenges of nanoparticle formulation are met. Based on the research till date and available resource suggest it is possible to target multiple genes or protein or enzymes or signaling molecules using biodegradable and biocompatible nanoparticles (NP) loaded with siRNA and drugs or combination of drug and siRNA.

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Co-encapsulation of resveratrol and curcumin in lipid-core nanocapsules improves their in vitro antioxidant effects

Cited by 175 publications

References 47 publications

Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

Preparation, characterization, and efficacy of thermosensitive liposomes containing paclitaxel

Biodegradable Nanoparticles for Delivering Drugs and Silencing Multiple Genes or Gene activation in Diabetic Nephropathy

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